Top Tweets for #CDK5
Article✍️#CDK5-triggered #G6PD phosphorylation at threonine 91 facilitating #redox #homeostasis reveals a #vulnerability in #breast #cancer. From Dr. Shen @NanjingUniversity; Dr. Ji @PekingUniversity; @ELSpharma.
https://t.co/ju73XwCRXl.
#neurodegenerativedisease #Cdk5 #aberrantcellcycle
Cdk5 and aberrant cell cycle activation at the core of neurodegeneration
https://t.co/3ziUd0ME22
@Univcordoba
Cdk5i #Peptide Mitigates #Neurodegeneration Seen in Alzheimer’s Disease ��
↑ #Neuroprotection
↓ #Tau aggregation (neurofibrillary tangles)
↓ #Neurodegeneration
↓ #Mitochondrial dysfunction
↑ #Cell survival
#Peptides #CDK5 #Alzheimer #p25 #BetaAmyloid
https://t.co/o4s9CI8AOx
📢Welcome to read the paper "#EPAC2 knockout causes abnormal tau #pathology through calpain-mediated #CDK5 activation"
👥By Ling-Qiang Zhu et al.
📖Read and download at: https://t.co/bkpEg3CdRs
Liu, Yan et al. use a data-driven approach to discover the structure-activity relationships of #CDK5 inhibitors, to help identify scaffolds and fragment features associated with highly active compounds. Read more in today's featured article:
https://t.co/BWdG8Nb9Fi #openaccess
What a cool lecture by Professor Dipanjan Chowdhury @harvardmed today in Frontiers of Science seminar! We bet the participants learned some amazing aspects about #CDK5...
#DNArepairfactors
@UniTurku
@AboAkademi
@BioCityTurku @westermarcklab
#EditorsPick: By regulating CDK5 activity through a decrease of CDK5R1, D-Pinitol is a potential drug for developing treatments for neurological disorders such as tauopathies: https://t.co/jPLYFXfC7u
#DPinitol #CDK5 #CDK5R1 #tauopathies
#Seliciclib (#Roscovitine) is an orally bioavailable and selective #CDKs #inhibitor with IC50s of 0.2 μM, 0.65 μM, and 0.7 μM for #CDK5, #Cdc2, and #CDK2, respectively. #drugdiscovery. https://t.co/V1EruT1YB3
New Drug Could Help Stop #Depression, #Anxiety, Brain Injury, and Cognitive Disorders: The preclinical drug works by inhibiting the kinase Cdk5 which is found in mature neurons... https://t.co/4rxab3QP58 | @SciTechDaily1 #Science #kinase #Cdk5
Novel #Preclinical #Drug could have potential to combat #Depression, #Brain #Injury and #Cognitive disorders
The drug, which notably is brain-permeable, acts to inhibit the kinase enzyme #Cdk5. See more... https://t.co/9rZ03vJ9Hl
Unexpected function for #PI3P-containing #endosomes in control of #presynaptic #vesicle cycling & #neurotransmission:
@VolkerHaucke @TolgaSoykan et al @LeibnizFMP find auto-inhibitory feedback of #neuronal activity via Calpain-mediated #CDK5 activation
https://t.co/j35JyD05Kx
Our latest paper on Cdk5 in breast cancer is out today - this makes me very happy given the current situation!
https://t.co/BNH6W1Ue4B
#cdk5 #breastcancer @UniofNottingham @NottmBCRC @MedicineUoN
#publication 📖| Cyclin dependent kinase 5 #CDK5 regulates the circadian clock @eLife
https://t.co/hQ8Ja7ser7
#Maladie de #Huntington🙎♂️🙎♀️: une étude chez la #souris🐁 découvre le mécanisme à l'origine de la #dépression☹ précédant les symptômes neurodégénératifs🧠. Altération de la kinase #Cdk5 et modification de la voie de signalisation #DARPP32 https://t.co/XKdzQRVCb8
#Cdk5 gene → early brain development #ALS, #Alzheimer’s,#Parkinson’s. Altering gene → death of #dopamine-releasing neurons, especially in brains of older flies. Neuron loss due to slowing of #autophagy. [open access]. https://t.co/6bFBp4L0tB https://t.co/0hD1n5eNlg
![HellenGreenblat's tweet photo. #Cdk5 gene → early brain development #ALS, #Alzheimer’s,#Parkinson’s. Altering gene → death of #dopamine-releasing neurons, especially in brains of older flies. Neuron loss due to slowing of #autophagy. [open access]. https://t.co/6bFBp4L0tB https://t.co/0hD1n5eNlg https://t.co/24doIhjQTC](https://pbs.twimg.com/media/Dw38jhrWkAA6v-t.jpg)
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