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Young onset Parkinson's and Charcot Marie Tooth together? Possible? YES. It is called 'FIG 4' and this is the 6th case reported by Silva and colleagues and it was levodopa responsive ~50% improvement in UPDRS. Pallidal hypointensities suggestive of iron deposition. CT scan normal [123I] FP-CIT SPECT bilateral presynaptic dopaminergic deficit Hoe about the CMT? Electromyography revealed a sensory-motor polyneuropathy with distal-to-proximal gradient and some demyelinating features. 'FIG 4 is a phosphatase, functioning in a trimolecular complex with PIKFYVE (PI3P kinase) and VAC14 (scaffold protein), regulating the levels of PI(3,5)P2 in the endolysosomal membrane. VAC14 associated with NBIA (iron deposition disease). FIG 4 pathogenic variants lead to dysfunction of PI,P2.' https://t.co/pSSuiKYRPw