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There’s never a bad day to learn something new. We strive to share the most up to date educational content we can. 💚🪴
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Your daily dose of calm, convenience, and consistency. ✔️
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CBD isn’t just cool—it’s clinical. 👨⚕️ Backed for pain, sleep & stress relief.
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Meet the lineup. 🌟 Multiple strengths, unique blends, same premium Hemp Bombs quality.
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Your wellness, your way. 🌟 Gummies or capsules—Hemp Bombs® makes CBD simple, portable, and effective
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Not all CBD products are the same! Before choosing your next one, learn the differences so you get exactly what you need.
#CBD #CBDWellness #CBDHealth
🔬🧬🩺WHAT IS MCAS? #ImmuneSystem #CBD #cbdhealth
Mast Cell Activation Syndrome (MCAS) is a chronic, misunderstood condition where your immune system's mast cells become hypersensitive, releasing inflammatory chemicals such as histamine, leukotrienes, cytokines and prostaglandins.
These chemical signals are beneficial during infections or injury but in MCAS, they're released too often, too easily and without a true trigger.
This creates a storm of symptoms across the entire body, often dismissed, misdiagnosed or misunderstood.
🌱CANNABIS CANNABINOIDS & MCAS
▶️Emerging research on cannabinoids in Mast Cell Activation Syndrome (MCAS) suggests that the next few years will likely bring early clinical trials translating promising lab evidence on mast cell, cytokine and lipid mediator modulation into targeted therapies with improved tolerability and precision.
WILL CANNABINOIDS NOT ITS CANNABIMIMETIC STAND-INS EMERGE AS THE TRUE GAME-CHANGER FOR MCAS TREATMENT?
▶️CBD - Cannabidiol:
Histamine/mast-cell degranulation: in primary human and mouse mast cells, CBD inhibited IgE-mediated degranulation and reduced passive cutaneous anaphylaxis in vivo. (Histamine release is the key readout of that degranulation). (Europe PMC)
Leukotrienes: in human monocyte-derived macrophages, CBD acted as a lipid-mediator class switch, suppressing 5-LOX leukotriene formation while boosting specialised pro-resolving mediators via 15-LOX-1; the effect was also shown in murine peritonitis model. (Science Direct)
Cytokines: multiple in-vitro human immune cell studies show reductions in IL-6, TNF-a, IL-1B with CBD or high-CBD extracts; clinical trails measuring broad cytokine panels are still limited. (Frontiers)
Prostaglandins: CBD itself can inhibit COX activity in vitro (cell/enzyme assays that measure PGE2), though this is weaker and less selective than CBDA. (JSTAGE)
Clinical evidence indicates that CBD has shown a direct hit on histamine release biology. Cannabimimetrics don't show equally strong human-cell data on LT suppression.
▶️CBDA - Cannabidiolic Acid
Prostaglandins: selective COX-2 inhibitor predicts lower PGE2 production. This is one of the clearest prostaglandin-axis effects among phytocannabinoids. (https://t.co/mSfwYJQMiu) (Higea CBD)
(No direct human data yet on histamine or leukotrienes; cytokine effects mostly inferred from COX-2/PGE2 modulation).
Clinical paper - (Takeda et al, 2008) - "Cannabidiolic Acid as a Selective COX-2 Inhibitory Component in 🌱Cannabis," reported CBDA as a selective COX-2 inhibitor. (https://t.co/mSfwYJQMiu) (Higea CBD)
▶️CBG - Cannabigerol
Cytokines: in vitro and animal neuroinflammation/arthritis models show reductions in TNF-a, IL-1B, IL-6 (microglia; PBMC/RASF systems). (J Pharmacol Exp There) (SpringerLink) (MDPI)
Prostaglandins: reports of lower PGE2 in LPS-stimulated microglia, broader COX inhibition also shown in the 6-Cannabinoid COX Study. (J Pharmacol Exp There) (JSTAGE)
▶️THC - Tetrahydrocannabinol
Cytokines: in human T-cell/DC co-culture, THC suppressed T-cell proliferation and shifted Th1/Th2 cytokines (e.g., reduced IFN-y); numerous older immune cell studies also show down tuning of pro-inflammatory cytokines at pharmacologically relevant-to-high-concentrations. (ScienceDirect) (SpringerLink)
Prostaglandins: part of the comparative COX/Cell PGE2 inhibition work across 6 phytocannabinoids. (weaker than CBDA) (JSTAGE)
There is potential for multi-compound synergy ("entourage effect") - reviews and human observation/clinical comparisons (e.g., full-spectrum vs purified CBD in refractory epilepsy) suggest complex Cannabis 🌱 matrices can outperform isolates at lower doses, plausibly via cannabinoid-terpene-flavonoid interactions when multiple mediator axes (histamine, LTs, cytokines, PGs) need coordinated dialing down. (Frontiers)
🪩Beyond mast cells and leukotrienes, cannabinoids (CBD, CBG, THC) show in vitro human-cell reductions in IL-6/TNF-a and modulation of PGE2/COX covering cytokines and prostaglandins in the same pharmacologic family which cannabimimetrics typically target only in part. (ScienceDirect)
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🌿 CBD lovers, it’s time to stock up!
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The number1 CBD Massage Oil. Recovery formula
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Because great days start with great nights. 🌙💤
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When medications fail, is there another way? Ethan Pompeo spent years trapped in a cycle of prescriptions—until CBD transformed his health. 🌿
🎙️ Join us as we explore the power of alternative healing.
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#CBDHealing #cbdhealth #cbdoil #pandaslife #cbdproducts #HealthTransformation #hemp #alternativemedicine #mindbodyspirit #WaismannMethod #RapidDetox #WaismannMethodPodcast #podcast #podcasts @ethan_pandas
Visit us to learn more about CBD and the products we offer 🔥
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Hemp Bombs is setting the industry standard with:
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