Top Tweets for #Defibrotide
Curious if anyone in the #hepatology world has used #defibrotide for #sinusoidalobstructionsyndrome ?
The world’s experience seems to be limited to BMT folks
#livertwitter
Defibrotide Emerges as Lifesaving Therapy for COVID-19 and Blood Cancers
https://t.co/KVN0lzuVI8
#COVID19 #SARSCoV2 #News #BloodCancer #Health #Drugs #Meds #Defibrotide
#Defibrotide availability ZERO in India & cost to import is very ⬆️so making this only available & effective therapy for VOD inaccessible to patients in India
It’s high time cost is ⬇️ & drug gets licensed in India for #BMT patients
At present prevention is most important
Defibrotide outcome:
-multicenter study of children and adults compared with 32 historical control patients👉defibrotide with superior day +100 survival (38 versus 25%) and day +100
-fatal hemorrhagic events were reported in 15% of defibrotide versus 6% of controls
12/15
Alerte produit médical d'un lot falsifié de #DEFITELIO (#defibrotide sodium) détecté aux Émirats arabes unis & signalé par l’autorité nationale de réglementation (en novembre 2022). Le lot falsifié a également été détecté au Kirghizistan (en mars 2023).👇
https://t.co/rimWcHfCXN
This was prevention and not treatment. Patients who developed VOD on the best supportive care arm went on to get #defibrotide
@AlpBugraBasat @TheLancetHaem Thx for asking & heck no.
#Defibrotide works for VOD. I use it, often successfully. Need to use it early. This was a VOD prophylaxis study. Didn’t see an prevention effect. Might’ve seen something if we defined ultra high risk groups, but we did it the way we did it.@JazzPharma
Letters have also been sent to health care professionals about
#dexmedetomidine https://t.co/AQcKxOke62
#defibrotide https://t.co/zsVbN18Nut
#talimogene https://t.co/NJaYnzvYYX
and #calciumfolinate https://t.co/biUWshxY2v
https://t.co/AQcKxOke62
📣 Towards future treatments #ICAPA2022🇦🇷
🆕 Dr Doruk Erkan explains reasons for potential use of #defibrotide and #daratumab in #antiphospholipidsyndrome
#APSmatters
@APS_ACTION
#Tandem22 @Mohty_EBMT:
Take home slide:
- Largest real world data on post-reg #defibrotide use in #VOD
- Day 100 OS: 88% peds, 53% adults
- Early dx assoc with better outcomes
- Adds to evidence that defibrotide effective in VOD
#Tandem22 @Mohty_EBMT:
DEFIFrance study on ped/adult #BMT pts with severe #VOD in France who received #defibrotide
Median time from dx to tx was 0 days (no delay)
Ped & Adult severe VOD Survival curves 👇
“NETs are major contributors to #bloodclotting in patients w an #autoimmunedisease known as #antiphospholipidsyndrome..#Defibrotide was 1st reported as a possible treatment for a life-threatening form of #APS some 20 years ago": https://t.co/GHELOJOAEP @MHealthLab
📖 In this review, emerging preclinical and clinical data support #defibrotide for treating or preventing other conditions driven by #endothelial cell activation, dysfunction, and/or damage.
Open access: https://t.co/fiBTI9lWqz
#Defibrotide treatment in VOD/SOS patients w/ @Mohty_EBMT of @HUEstParisien: https://t.co/b9wc5H8reE
@VJHemOnc @ASH_hematology #ASH20 #HemOnc
#destacadoSEHH El #defibrotide, el 'aliado' de la #vacuna que se estudia en #Murcia https://t.co/uGhOk8MbOR a través de @diariolaopinion @adri_gonzalez96
Nice meeting!! Thanks to all of you @SelimCorbaciog1 @JazzPharma @GETH_info We learnt a lot about #defibrotide but the most important thing is that science is the cure!!
In this research letter, .@Sara_Alosaimy, #oncology & #IDtwitter #pharmacists and team report on the observation and validation that #defibrotide administration can lead to quantifiable #betaglucan measurements in #HCT patients with #VOD.
full text link:https://t.co/OCiv6SGgsb
#Defibrotide falsifié, objet de l'alerte OMS N°5/2020, identifié en Australie, Lettonie et Arabie Saoudite Nom du produit DEFIBROTIDE 200MG VIALS OF 2.5ML (80MG/ML) CONCENTRATE FOR SOLUTION FOR INFUSION Fabricant déclaré GENTIUM S.R.L
https://t.co/oedKuS03kN
Renversant si cette note existe. #OCC n'a pas vocation à traiter cette matière qui relève du @MinSanteRDC. Combien de fois devrons-nous le dire? @LongondoEteni @Presidence_RDC @PrimatureRDC @Commext_RDC @DBangala @radiookapi @lusakuenoc @elysee_odia @RMonunu @LuvDRC @KawelMbang
New article by BET group with @PalomoMarta in @BMTjournal demonstrating that deleterious damage on the endothelium caused by induction strategy therapies against #MultipleMyeloma can be avoided by combining this treatment with #defibrotide.
➡️ https://t.co/FTvE0GNRY7
Entrevista en @laverdad_es a José María Moraleda: "El ensayo clínico con el medicamento #defibrotide estará concluido en tres o cuatro meses y tenemos muchas esperanzas depositadas en él" #COVID19
https://t.co/3KqqAh28Fx
Porque dar buenas noticias es igual de importante: el @biobancoimib lidera un ensayo clínico con #defibrotide en #Covid_19 que podría frenar la mortalidad en los casos graves de coronavirus. Vía @GacetaMedicaCom https://t.co/lTf2dcjUgd
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