#Disopyramide - Twitter Hashtag

5 months ago

In this cohort of patients with symptomatic #oHCM with persistent #LVOT obstruction, combination therapy with #aficamten and #disopyramide was safe and well tolerated but did not enhance clinical efficacy vs aficamten alone. https://t.co/3wZ0N2EC8N #JACCHF #cvHCM

JACCJournals's tweet photo. In this cohort of patients with symptomatic #oHCM with persistent #LVOT obstruction, combination therapy with #aficamten and #disopyramide was safe and well tolerated but did not enhance clinical efficacy vs aficamten alone. https://t.co/3wZ0N2EC8N #JACCHF #cvHCM https://t.co/7B410zfL4I

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@cardiomet_CE

about 1 year ago

16) In fact this has spurred advances in #oHCM management beyond the often limited effects of #betablockers and #disopyramide. Invasive #SRT was really the only effective strategy for oHCM.

cardiomet_CE's tweet photo. 16) In fact this has spurred advances in #oHCM management beyond the often limited effects of #betablockers and #disopyramide. Invasive #SRT was really the only effective strategy for oHCM. https://t.co/kEOcLZTsa4

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Steve Ommen, MD @SteveOmmen

about 2 years ago

Excited for #HCMSummit8? Don't miss #MarkSherrid's must-see talk on "Traditional Medical Therapies w/ #BetaBlocker / #CalciumChannelBlockers (And Don’t Forget about #Disopyramide)". Get your tickets now at https://t.co/XK17fomHys. #cardiotwitter #hypertrophiccardiomyopathy #hcm

SteveOmmen's tweet photo. Excited for #HCMSummit8? Don't miss #MarkSherrid's must-see talk on "Traditional Medical Therapies w/ #BetaBlocker / #CalciumChannelBlockers (And Don’t Forget about #Disopyramide)". Get your tickets now at https://t.co/XK17fomHys. #cardiotwitter #hypertrophiccardiomyopathy #hcm https://t.co/Ch9hkt0EcG

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@cardiomet_CE

over 2 years ago

13c) All but #disopyramide are class III anti-arrhythmic 💊 (option 1). Class III #AAD block cardiac K channels to prolong repolarization. Includes several types of 💊differing in certain specific properties. 🔓 https://t.co/wjFsqvSMsQ

cardiomet_CE's tweet photo. 13c) All but #disopyramide are class III anti-arrhythmic 💊 (option 1).
Class III #AAD block cardiac K channels to prolong repolarization. Includes several types of 💊differing in certain specific properties.
🔓 https://t.co/wjFsqvSMsQ https://t.co/jNIaXJspNj

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@cardiomet_CE

about 3 years ago

24h) In the #VALOR trial, treatment with #mavamcamten was shown to reduce the use of septal reduction therapy. VALOR also showed the possibility to combine mavacamten with #disopyramide 🔓 https://t.co/5DIfYsAxSZ

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@cardiomet_CE

over 3 years ago

20b) Among these pts, 42% were eligible for #SRT at baseline and 22% were taking #disopyramide. Main results are shown here:

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@cardiomet_CE

over 3 years ago

8) Current treatment for obstructive #HCM (#oHCM or #HOCM) rests on septal reduction therapies (#SRT), and the use of drugs developed for other purposes, such as beta-blockers (BB), calcium antagonists (#CCBs), and #disopyramide.

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@cardiomet_CE

over 3 years ago

38) Moreover, 10% pts were on #disopyramide & there were no safety signals when the 2 drugs have been coadministered. #VALOR_HCM

cardiomet_CE's tweet photo. 38) Moreover, 10% pts were on #disopyramide & there were no safety signals when the 2 drugs have been coadministered. #VALOR_HCM https://t.co/9ULy8iDh9s

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@cardiomet_CE

over 3 years ago

16) Therefore, #disopyramide should be avoided in glaucoma, men with prostatism, & patients taking other drugs that prolong the QTc interval. Another caution (as Class IA antiarrhythmic) is #AFib in whom drug-induced enhancement of AV conduction can increase the ventricular rate.

cardiomet_CE's tweet photo. 16) Therefore, #disopyramide should be avoided in glaucoma, men with prostatism, & patients taking other drugs that prolong the QTc interval. Another caution (as Class IA antiarrhythmic) is #AFib in whom drug-induced enhancement of AV conduction can increase the ventricular rate. https://t.co/YL8AI2AGY3

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@cardiomet_CE

over 3 years ago

15) Finally, #disopyramide (used as 2nd or 3rd line therapy often in association) has as main limitation anticholinergic side-effects e.g. dry eyes & mouth, urinary retention, & constipation. Moreover, #QTc prolongation is not rare & should be monitored during dose up-titration.

cardiomet_CE's tweet photo. 15) Finally, #disopyramide (used as 2nd or 3rd line therapy often in association) has as main limitation anticholinergic side-effects e.g. dry eyes & mouth, urinary retention, & constipation. Moreover, #QTc prolongation is not rare & should be monitored during dose up-titration. https://t.co/jrumfQaIf3

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Ahmad Masri

@MasriAhmadMD

over 3 years ago

Mark Sherrid with a great talk on #disopyramide Here is the summary slide: #HCM #CardioTwitter

Ahmad Masri

@MasriAhmadMD

over 3 years ago

It is 2023 and if you are ready for some more #HCM learning in the new year, join a group of us at the NYU Management Decisions in #HCM (Directors: Sherrid, Massera & Swistel). https://t.co/Qwoqgr6Sb9 #CardioTwitter

MasriAhmadMD's tweet photo. It is 2023 and if you are ready for some more #HCM learning in the new year, join a group of us at the NYU Management Decisions in #HCM (Directors: Sherrid, Massera & Swistel).

https://t.co/Qwoqgr6Sb9

#CardioTwitter https://t.co/P0Evbz2Gbo

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@cardiomet_CE

over 3 years ago

71) Back to #REDWOOD, there was a 3rd Cohort of patients with obstructive #HCM refractory to an AV nodal blocking agent + #disopyramide. Abstract 🔓https://t.co/YEoTqQDwQM

$cardiomet_CE's tweet photo. 71) Back to #REDWOOD, there was a 3rd Cohort of patients with obstructive #HCM refractory to an AV nodal blocking agent + #disopyramide. Abstract 🔓https://t.co/YEoTqQDwQM https://t.co/lAhpEJxchW$

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Harriette Van Spall, MD MPH 🇨🇦 @hvanspall

almost 6 years ago

👆🏽What are your thoughts on how #mavacampten may compare #disopyramide? What about attenuated effect with #betablockers? @jct_ucb @SilCastelletti @GiuseppeGalati_ @krychtiukmd @RRBaligaMD @totocarbone @NadeenFaza @gina_lundberg @jeanlucvachiery @a_l_bailey @MyoKardia @Hragy

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MScBMC @MScBMC

over 6 years ago

.@UTM alumnus-led team @Cyclica uses #AI to predict that drug #disopyramide will interact with human protein #TMPRSS2 involved in #SARSCOV2 infection. If validated pre-clinically, could mean acute treatment for #COVID19. https://t.co/PufqmKe5NX

MScBMC's tweet photo. .@UTM alumnus-led team @Cyclica uses #AI to predict that drug #disopyramide will interact with human protein #TMPRSS2 involved in #SARSCOV2 infection. If validated pre-clinically, could mean acute treatment for #COVID19. https://t.co/PufqmKe5NX https://t.co/jaqa5jMBPV

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MScBMC @MScBMC

over 6 years ago

@UTM alumnus-led team @Cyclica uses #AI to predict that drug #disopyramide will interact with human protein #TMPRSS2 involved in #SARSCOV2 infection. If validated pre-clinically, could mean acute treatment for #COVID19. https://t.co/w2ICAmYYg7