Top Tweets for #VALOR_HCM
17d) In #VALOR_HCM, #mavacamten also ➡️significant improvements in the degree of mitral regurgitation #MR and in systolic motion of the anterior mitral valve leaflet #SAM:

16a) So, more data: #VALOR_HCM, a #RDBPC trial, aimed to assess #mavacamten in pts w/ #oHCM who were referred for or actively considering septal reduction tx #SRT. Included:
🫀 at least 18
🫀 LV wall thickness ≥ 15 mm (13 mm if familial)
🫀 #NYHA class 3 or higher (2 if syncope)
34) Let’s take a quick breather! RETURN TOMORROW and we’ll look at substudies from #EXPLORER_HCM, at #VALOR_HCM and #MAVERICK_HCM, and we’ll also talk about an emerging medical treatment, #Aficamten. Tomorrow you’ll also get your link to your 🆓CE/#CME!
38) Moreover, 10% pts were on #disopyramide & there were no safety signals when the 2 drugs have been coadministered. #VALOR_HCM

37) #VALOR_HCM demonstrated even more important result of #mavacamtem in #HOCM, Indeed it significantly reduced the need for #SeptalReductionTherapy. The previous benefits has been confirmed as the safety profile.
👉 https://t.co/pFpnR7KX11

50) A second phase 3 trial, #VALOR_HCM (presented at #ACC22), recruited patients who were referred to septal reduction therapy based on symptoms (typically NYHA class III/IV) + obstructive LVOT gradient > 50 mm Hg.
See https://t.co/6q566MGxEl.
🔥#VALOR_HCM
Important results for #Mavacamtem vs Placebo in #HOCM ⬇️ the need of
🔪 Septal miectomy
🍷 Septal Ablation
@radcliffeCARDIO
#ACCRME #ACC22
@DrMarthaGulati @IacopoOlivotto @AlessiaArgiro @SilCastelletti @CSHeartResearch @MicheleSenni @KTamirisaMD @gbiondizoccai

🔥 #VALOR_HCM
#Mavacamtem vs Placebo significant ⬇️ the need of #SeptalReductionTherapy in #HOCM driven by choice of pts (important)
Short follow-up
But ⬇️ Biomarkers
🍀No signal of safety concern
@radcliffeCARDIO
@ShelleyZieroth @hvanspall @nephondemand @ValleAlfonso
#ACCRME

👆 #ACC2022
#ACCRME
However don’t miss
The other important #RCTs #HeartFailure & #Cardiomyopathies
🧩#VALOR_HCM
🧩#PROMPT_HF
🧩#Explorer_LTE + #Mava_LTE
@radcliffeCARDIO
@JJheart_doc @DrNasrien @markcpetrie20 @MicheleSenni @DrDEliaEmilia @MichelaBraMD @DrRajivsankar

🔥 Warming up for the great line-up #ACC22 is fast approaching
Further on #RCTs #HeartFailure & #Cardiomyopathies
🧩#VALOR_HCM
🧩#PROMPT_HF
🧩#Explorer_LTE + #Mava_LTE
#HF is the reinassance of cardiology
#Cardiotwitter
#ACCRME
@radcliffeCARDIO
👉 https://t.co/BCymrEuW5N

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