Top Tweets for #EMBOerfunction
On my way to Florence for the weekend after a great week at the #EMBOerfunction workshop in Lucca. Met super nice people, definitely learned a lot and got inspiration for my new project in #cellbiology #straybiophysicist #PhDchat
Closing keynote by @PietroDeCamilli #EMBOerfunction on molecular details of lipid transport from the ER with highlights from https://t.co/uzgf0vMNhB
Robin Klemm & his first PhD student Christophe Freyre: Mitoguardin-2 mediates spatial and functional interactions between mitochondria and lipid droplets in adipocytes: required for de novo lipid biosynthesis #EMBOerfunction
Antonella De Matteis: ER doesn’t just send secretory vesicles to Golgi. ER-TGN contacts that use ORP10 also allow lipid exchange, lower TGN PI4P levels, inhibit ApoB100 secretion, and so maybe obesity? Lots more too! #EMBOerfunction
Jodi Nunnari: ER/mito contact sites position CoQ biosynthesis domains in mitochondria; a mechanism for efficient coupling of lipid biosynthesis to metabolism? #EMBOerfunction
Robert Farese: Structure of seipin 10x/11x/12x-mer luminal domain explains many features of seipin, raises fascinating new questions too. Seipin foci found throughout ER tubules, yet 150Å diameter on luminal face must be a tight squeeze inside smaller ER tubules? #EMBOerfunction
Indeed! Good and well delivered data! And the only female speaker of the day so far at #emboerfunction. #WomenInSTEM
Delighted to be at the #EMBOerfunction meeting.
Great to meet and talk to great people in the field. Thanks to the #UoBAlumniFoundation and BSCB Honor FellTravel Awards (sponsored by the Company of Biologists) for making this possible.
John Christianson: EMC not required for viability. Clients for ER membrane insertion include cholesterol pathway enzymes SQS and SOAT1, so loss of EMC impairs cholesterol tolerance #EMBOerfunction
Pedro Carvalho: similarities in biogenesis of lipid droplets and peroxisomes from ER, using reticulon-like protein PEX30 (maybe an ortholog of MCTP2?) #EMBOerfunction
Randy Hampton: yeast forward genetic screen by Sonja Neal, for stabilised GFP fusion, identifies Dfm1 retrotranslocase for ER integral membrane protein. Previously missed due to rapid accumulation of suppressors (Hrd1 retrotranslocon) in stressed cells! #EMBOerfunction
Tom Rapoport: structure of the ER retrotranslocation machinery: protein membrane bilayer thinning may be a general feature of protein translocation machineries #EMBOerfunction
Learning a lot about what the endoplasmic reticulum does these days...great talk by Tom Rapoport on ERAD #EMBOerfunction
Sandra Torres: Ceapin small molecule inhibitors of ATF6alpha #EMBOerfunction. Irish speakers will understand why it’s pronounced like “kappin”!
Rupali Prasad: At neck of budding yeast, ER/ONM diffusion barrier, influenced by TM length, and ceramide-based thicker lipid domain at neck #EMBOerfunction
Andrew Moehlman (Helmut Krämer): Drosophila photoreceptors as in vivo model for BiP AMPylation and deAMPylation. Massive amounts of rhodopsin means lots of potential for ER stress, and mechanisms to minimise it
Tadashi Suzuki #EMBOerfunction unravels long standing mysteries of the ER-originating N-glycans’ fate in cytoplasms
Patrick Chitwood (Manu Hegde): very nice biochemistry on EMC, using ER extracts from WT and mutant cells. EMC required for 100% correct TM domain orientation of GPCRs
Today at 3pm Joe Chambers Will be presenting his post “ER proteostasis in a1-antitrypsin deficiency” #EMBOer #EMBOerfunction @AlphaFriend @The_MRC
Drop by @MolinariLab @OKaneCahir @ddoultsinos
EMC insights in membrane insertion from Patrick Chitwood in Manu Hegde's lab #EMBOerfunction
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