Top Tweets for #ExASPIM

7 days ago

Please read my #sciencewriting article about #ExASPIM #microscope and its #appliedimpact on #science and #neurobiology. © #StefanFWirth, July 2026, Berlin Please support my science writing and illustration efforts: https://t.co/4nN4eRHB6I #Illustration: © Stefan F. Wirth, June 2026, #AIassisted artistic illustration, based on my hand-drawn storyboard sketches, manually edited and modified: #Mousebrain

Stefan F. Wirth

@wirthstef

11 days ago

Fantastic detailed images in this #video (see link) about the distribution of #neurons in a #mousebrain. The work is based on an #ExASPIM #microscope, developed by the #AllenInstitute, which combines biology, classical light microscopy, and industrial manufacturing #technology to achieve effective #highresolution across a #fieldofview of approximately 10.6 × 8.0 mm². This was achieved through means such as large-format #lenses and efficient #imagesensors. Additionally, the tissue underwent #physicalexpansion by a factor of three to four, pushing the actual resolution beyond the limits imposed by standard light diffraction. This technology opens up paradigm-shifting possibilities for the #future; the combination of #nanoscaleresolution and massive image volumes enables, for instance, the complete mapping of brains (#connectomics). In the field of comparative #evolutionarybiology, this allows for the reconstruction of #neuronalarchitectures across the animal kingdom, thereby revealing steps in #phylogenetic development. In #humanmedicine, too, the technology can contribute to a better understanding and earlier detection of conditions such as #neurodegenerativediseases. © Text: Stefan F. Wirth, June 2026, Berlin Link and Reference: Allen Institute, post in X (2026): https://t.co/st4g49Anu9 Illustration: © Stefan F. Wirth, June 2026, #AIassisted artistic #illustration, based in my hand-drawn storyboard sketches, manually edited and modified: external morphology of a mouse brain

$wirthstef's tweet photo. Fantastic detailed images in this #video (see link) about the distribution of #neurons in a #mousebrain. The work is based on an #ExASPIM #microscope, developed by the #AllenInstitute, which combines biology, classical light microscopy, and industrial manufacturing #technology to achieve effective #highresolution across a #fieldofview of approximately 10.6 × 8.0 mm². This was achieved through means such as large-format #lenses and efficient #imagesensors. Additionally, the tissue underwent #physicalexpansion by a factor of three to four, pushing the actual resolution beyond the limits imposed by standard light diffraction. This technology opens up paradigm-shifting possibilities for the #future; the combination of #nanoscaleresolution and massive image volumes enables, for instance, the complete mapping of brains (#connectomics). In the field of comparative #evolutionarybiology, this allows for the reconstruction of #neuronalarchitectures across the animal kingdom, thereby revealing steps in #phylogenetic development. In #humanmedicine, too, the technology can contribute to a better understanding and earlier detection of conditions such as #neurodegenerativediseases. © Text: Stefan F. Wirth, June 2026, Berlin Link and Reference: Allen Institute, post in X (2026): https://t.co/st4g49Anu9 Illustration: © Stefan F. Wirth, June 2026, #AIassisted artistic #illustration, based in my hand-drawn storyboard sketches, manually edited and modified: external morphology of a mouse brain$

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Stefan F. Wirth

@wirthstef

11 days ago

allen institute @AllenInstitute

11 days ago

Dive into the intricate connections in the mouse brain! 🧠✨ This video shows reconstructed neurons projecting from the thalamus to various regions of the cortex. Each neuron was fluorescently labeled and imaged with our cutting-edge ExA-SPIM microscope.

Fabian F. Voigt @voigtvision

over 2 years ago

Beautiful work pushing the boundaries of #lightsheet #microscopy of cleared tissue by @adam_k_glaser and team @AllenInstitute #exaspim - now out in @eLife! https://t.co/NAAFL2XTFX

eLife - the journal @eLife

over 2 years ago

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint https://t.co/7D3JyPGvWo

132

35K

TNN Online @tnnthailand

almost 3 years ago

กล้องจุลทรรศน์ใช้เลเซอร์แทนเลนส์ ส่องเห็นชัดระดับเส้นประสาทในสมอง #กล้องจุลทรรศน์ #ExASPIM #สมอง #เลเซอร์ #ระบบประสาท #การแพทย์ #กล้อง #วิจัย #นวัฒกรรม #นักวิทยาศาสตร์ #TNN #TNNTechreports #Techreports #TNONLINE #TNNThailand #TNNช่อง16 #ข่าวtiktok #tnn online #TNNTech

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