Top Tweets for #exaspim
Please read my #sciencewriting article about #ExASPIM #microscope and its #appliedimpact on #science and #neurobiology.
© #StefanFWirth, July 2026, Berlin
Please support my science writing and illustration efforts:
https://t.co/4nN4eRHB6I
#Illustration:
© Stefan F. Wirth, June 2026, #AIassisted artistic illustration, based on my hand-drawn storyboard sketches, manually edited and modified:
#Mousebrain
Fantastic detailed images in this #video (see link) about the distribution of #neurons in a #mousebrain.
The work is based on an #ExASPIM #microscope, developed by the #AllenInstitute, which combines biology, classical light microscopy, and industrial manufacturing #technology to achieve effective #highresolution across a #fieldofview of approximately 10.6 × 8.0 mm². This was achieved through means such as large-format #lenses and efficient #imagesensors. Additionally, the tissue underwent #physicalexpansion by a factor of three to four, pushing the actual resolution beyond the limits imposed by standard light diffraction.
This technology opens up paradigm-shifting possibilities for the #future; the combination of #nanoscaleresolution and massive image volumes enables, for instance, the complete mapping of brains (#connectomics). In the field of comparative #evolutionarybiology, this allows for the reconstruction of #neuronalarchitectures across the animal kingdom, thereby revealing steps in #phylogenetic development.
In #humanmedicine, too, the technology can contribute to a better understanding and earlier detection of conditions such as #neurodegenerativediseases.
© Text: Stefan F. Wirth, June 2026, Berlin
Link and Reference:
Allen Institute, post in X (2026):
https://t.co/st4g49Anu9
Illustration:
© Stefan F. Wirth, June 2026, #AIassisted artistic #illustration, based in my hand-drawn storyboard sketches, manually edited and modified:
external morphology of a mouse brain

Fantastic detailed images in this #video (see link) about the distribution of #neurons in a #mousebrain.
The work is based on an #ExASPIM #microscope, developed by the #AllenInstitute, which combines biology, classical light microscopy, and industrial manufacturing #technology to achieve effective #highresolution across a #fieldofview of approximately 10.6 × 8.0 mm². This was achieved through means such as large-format #lenses and efficient #imagesensors. Additionally, the tissue underwent #physicalexpansion by a factor of three to four, pushing the actual resolution beyond the limits imposed by standard light diffraction.
This technology opens up paradigm-shifting possibilities for the #future; the combination of #nanoscaleresolution and massive image volumes enables, for instance, the complete mapping of brains (#connectomics). In the field of comparative #evolutionarybiology, this allows for the reconstruction of #neuronalarchitectures across the animal kingdom, thereby revealing steps in #phylogenetic development.
In #humanmedicine, too, the technology can contribute to a better understanding and earlier detection of conditions such as #neurodegenerativediseases.
© Text: Stefan F. Wirth, June 2026, Berlin
Link and Reference:
Allen Institute, post in X (2026):
https://t.co/st4g49Anu9
Illustration:
© Stefan F. Wirth, June 2026, #AIassisted artistic #illustration, based in my hand-drawn storyboard sketches, manually edited and modified:
external morphology of a mouse brain

Dive into the intricate connections in the mouse brain! 🧠✨
This video shows reconstructed neurons projecting from the thalamus to various regions of the cortex. Each neuron was fluorescently labeled and imaged with our cutting-edge ExA-SPIM microscope.
Beautiful work pushing the boundaries of #lightsheet #microscopy of cleared tissue by @adam_k_glaser and team @AllenInstitute #exaspim - now out in @eLife!
https://t.co/NAAFL2XTFX
New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint https://t.co/7D3JyPGvWo
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