Top Tweets for #FOSMANOGEPIX
En #AntimicrobAgChem REVISIÓN🙇🏻♀️📚#FOSMANOGEPIX antifúngico nuevo🆕 (Bloquea #Gwt1🙅🏻♂️)aún NO aprobado,Si EC F3
🔸Amplio espectro(C. auris, Aspergillus R azoles y candinas, scedosporium…)📈👻
🔸Amplia difusión(incluye SNC)🧠
🔸NO interacciones relevantes❌💊
https://t.co/Px72VZo8tL
@JannikStemler #ESCMIDGlobal2026
Data on #Fosmanogepix. Small sample but promising results!
New treatment strategies in Fungal infections! Need to guarantee availability and rapid access to these drugs in such a high mortality complications! @ESCMID
Excelente #REVISION📚en #JAC estrategias #ANTIFUNGICOS para hacer frente a #RESISTENCIAS🎯
🔸Cómo actuar para disminuir resistencias 🍄📉🛡️
🔸Nuevos antifúngicos (#Rezafungina, #Olorofilm y #Fosmanogepix) 🆕❌🍄
🔸Futuro (inmunoterapia y vacunas)🔮💉
🔗 🆓 https://t.co/32vfi2mwH8
Los nuevos #antifungicos ya están aquí 🆕❌🍄en @CIDJournal #FOSMANOGEPIX en infecciones INVASIVAS con escasas opciones de tratamiento📉💊💉👉🏻#Aspergillus, #Lomentospora prolificans, #Fusarium solani o #Mucor circinelloides
Recuerda: Hay nuevas opciones!
🔗https://t.co/vr20V6jSB4
El @NEJM publicó ayer el seguimiento de 13 pacientes con #meningitis por Fusarium solani, un 🍄🟫 que adquirieron durante una anestesia epidural en #Matamoros, Tamaulipas. 9 ☠️ x un🍄🟫 angioinvasor del sistema vertebrobasilar. Los supervivientes están recibiendo #fosmanogepix.
Addendum #3
IF IT IS SAFE AND EFFECTIVE WHY SELL IT?
Pfizer bought #fosmanogepix developer Amplyx in 2021 for undisclosed amount after $93m investment in it in 2020, yet in Nov 23 it sold the drug rights to Basilea for $37m, while keeping distribution rights if passing phase 3.
14/
What else? IT CAUSES FUNGI MUTATION:
"Following oral or intravenous administration, #fosmanogepix (is converted) to manogepix" BUT "Manogepix has been shown to induce a similar morphological change to that of echinocandins in filamentous fungi".
https://t.co/hgBIm7r5Yn
13/
The study was conducted between October 2018 and March 2020. Twenty-one participants received #fosmanogepix. FIVE DIED, but like with #mRNA, according to #Pfizer their "deaths were deemed unrelated to the study treatment by the investigator".
https://t.co/v3NSQa5rn8
12/
This brings us back to #Fosmanogepix. Which hospitals are now asking to approve the use of this drug on soldiers? I'll tell you:
1) Sheba Medical Center
2) Rambam Medical Center
3) Tel Aviv Sourasky Medical Center
WHY? BECAUSE ALL TOOK PART OF THE PHASE-2 TRIALS OF THE DRUG!
6/
What is #Fosmanogepix? According to Wikipedia, "Fosmanogepix is an experimental antifungal drug being developed by Amplyx Pharmaceuticals (now currently by Pfizer and Basilea)...investigated for its potential to treat various fungal infections"
5/
In her report @kettydor stated it never happened in previous wars, that they have tried to use experimental medicine but they didn't manage to save the soldier's life.
We are now being told that Israeli doctors now ask to use #Fosmanogepix, a new experimental Pfizer drug.
4/
@kettydor stated that fungi and mold that is present in the soil of Gaza contaminate their wounds, and that the soldier who got contaminated by two types of fungus and he died because of the fungus. She also stated that 10 more soldiers have the same problem.
#Fosmanogepix
3/
This "report" is a follow-up of what was reported by Israeli TV channel @kann_news's health "reporter" @kettydor, who stated that an Israeli soldier has died from an infection that was caused by fungus that is found in Gaza two weeks ago.
#Fosmanogepix
https://t.co/ISUjaxB3Nc
לפני שבועיים נפטר לוחם צה"ל שנפצע קשה לאחר שנדבק מפטריה מסוכנת הנמצאת באדמת הרצועה. האיגוד למחלות זיהומיות יקיים דיון חירום על הפטריות המסכנות את חיילי צה"ל בעזה | @kettydor עם הפרטים
#חדשותהערב
2/
My 1st tweet included a translation from Hebrew of a tweet that was posted today by @MaytalYasur, the health correspondent of an Israeli newspaper called @israelhayomheb.
#Fosmanogepix
https://t.co/uffUvdOtSt
לאור מספר מקרים של חיילים שנפצעו בעזה ושסובלים מזיהום פטרייתי, לאחרונה ביקשו רופאים במספר בתי חולים לייבא לארץ תרופה ניסיונית לטיפול בפטריות של חברת פייזר בשם Fosmanogepix כאשר באחד המקרים היא מיועדת לטיפול בחייל פצוע קשה שמאושפז בטיפול נמרץ בשיבא.
THE PFIZER LAB: THE GAZA WAR EDITION.
[THREAD]
#Pfizer is AGAIN using Israelis as a laboratory rats to test its products, AGAIN the Israeli ministry of health and Israeli doctors are taking part and AGAIN patients are not being informed that they are lab rats.
#Fosmanogepix
![eh_den's tweet photo. THE PFIZER LAB: THE GAZA WAR EDITION.
[THREAD]
#Pfizer is AGAIN using Israelis as a laboratory rats to test its products, AGAIN the Israeli ministry of health and Israeli doctors are taking part and AGAIN patients are not being informed that they are lab rats.
#Fosmanogepix https://t.co/l1CLEnbhB6](https://pbs.twimg.com/media/GCTEh3QWEAAfSX-.png)
Clinical Efficacy and Safety of a Novel Antifungal, #Fosmanogepix, in Patients with #Candidemia Caused by #CandidaAuris: Results from a Phase 2 Trial
@Dr_joeID @DrPappasID and colleagues
https://t.co/55tSPdb2pj
🔝 #Fosmanogepix is a first-in-class antifungal for the treatment of invasive fungal infections caused by 𝘊𝘢𝘯𝘥𝘪𝘥𝘢, 𝘈𝘴𝘱𝘦𝘳𝘨𝘪𝘭𝘭𝘶𝘴 and rare molds.
This systematic review summarizes the findings of published data on fosmanogepix.
👉More here: https://t.co/wJYpMJxMAy
Suggested answer:
#Fosmanogepix is first-in-class drug in clinical trials for Rx of IFI due to Candida, Aspergillus and rare molds.
It is an inhibitor of the fungal enzyme Gwt1, with in vitro activity vs yeasts and molds, including Fusarium.
https://t.co/c3LuaG5WlU
#MayoClinicIDPracticeUpdates continues with what is new in the pipeline for antifungal therapeutics by @pascalisID #olorofim #fosmanogepix #rezafungin #ibrexafungerp #opelconazole
#idweek2022 #idtwitter clinical trials in #fungal dz that may change your practice @stoverkr #oteseconazole #ibrexafungerp #rezafungin #fosmanogepix #ReSPECT trial #ReSTORE trial #meded #idmeded #AEGIS #APEX #candidemia #olorofim #opelconazole #aspergillus
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