Top Tweets for #GoodReasoning
Just to clarify my position. I am not negating the possible importance of microtubule contributions, oscillations, quantum properties, etc. They are likely important. But, for the narrow question of "what's the origin of bioelectric patterns", none of those are strictly speaking necessary. We need to get past the common claim that "we don't know where they come from" and that some mystery is necessary upstream or else it doesn't work. Mathematical properties of networks involving *only* gated ion channels and gap junctions are sufficient to give interesting self-organizing patterns with all kinds of cool computational properties. Ion channel activity, with nothing else added, in a set of connected cells can set up patterns ab initio from symmetry breaking and amplification. Like Turing Patterns in chemical media: you don't need upstream factors to get interesting bioelectric patterns. Lots of papers showing this on https://t.co/aEc2CYUwyD and by others.
But again, that doesn't mean that the real case isn't more complex than this minimal version, and it's entirely likely that other aspects of physics impinge on it in living cells - all these things likely work together.
The fields we're looking for are whichever ones give maximal control over the morphogenetic outcome. Whatever is the most tractable control interface. For now, that has been pure bioelectric modification via ion channel targeting - we make eyes, limbs, repair birth defects, normalize tumors, etc. in vivo (in whole-body animal model systems) by managing those. At some point, it may become more tractable to do this via targeting of cytoskeleton or EM dynamics or quantum interfaces. I'm open to all of that!! The more tools the better. But I've not seen any applications where large-scale growth and form in embryogenesis, regeneration, etc. can be controlled that way yet. Hopefully that work expands and offers additional handles on this process; regenerative medicine can use as many different interfaces as we can find.
@mc5506 @ianbaxter_uk @sadpankhurst @apaul_smith @TRobinsonNewEra @AMDWaters @ForBritainParty You know when you can only see one side of a conversation.. that means the others were blocked a while ago. #goodreasoning
The house is divided today for the Army/Navy game. Dad wants Navy bc his father started in the Navy and I want Army bc my grandma thought one of the players was cute back in her day. #GoodReasoning #MyGirl ๐๐ผ
@EFCCollins @JARiiseOfficial If John Arne Riise winning a European Cup is bog standard, then Everton, by winning sweet FA, are absolute dog shit #goodreasoning #Irish
Magddiet na ako. Pag may nagtanong bakit. Sagutin ko nang "Sasali ako Bb. Pililinas." ๐๐๐ #bbpilipinas2017 #goodreasoning hahaha
#ff or any day 4 #goodreasoning > @JoneBosworth @joanbunashe @AskJoshsMom @justcoachit @EdwardColozzi @AttyBMalkin #delightul ppl

Haha thanks @OldmanWatershed for making this appear in our feed :) #water #flooded #goodreasoning https://t.co/BULn4FcrFS
The human body is roughly 70% water. I'm not fat, I'm flooded.
#Express #Muslim'
#Goodreasoning
@mohammadshaikh_
#QuranSays by
#Mankind #Guidance
https://t.co/T2JDp2QNcd

Yea honestly if I was you I would ignore me too. #goodreasoning
@Purrsyn9 @c3ciliya @vgliatti @cjnapoet @CarlRamallo @deisycsanchez1 @CCChampagne #GoodReasoning #LikedMe
"I really don't need another beer, but I also don't need to be in PT School....but here I am."-@hollllla_mich ๐๐๐#goodreasoning
#follow any day 4 #goodreasoning > @VirtueWelle @TopazStudiosCOM @LifestyleOnline @modernmktgspark @HannaBGoss @MindyLevy :)
me: *cheers for Florida volleyball*
mom: I want Kentucky to win because I love horses..
#wut #goodreasoning
Sometimes I don't set an alarm before class & if I wake up I was meant to go to class & if not then it wasn't meant to be #goodreasoning
Me "What's your least favorite subject?"
Jake "Literature."
Me "Do you like math?"
Jake "Yes, because it's not literature" ๐ #GoodReasoning
#folllow 4 #goodreasoning > @DrCraigMalkin @DrPriceMitchell @stangoldberg @justcoachit @SitAtTheTable @AttyBMalkin #HAGW all~ jane
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