Top Tweets for #HDAC11
📢New Open🔓 Access Article in GeroScience
HDAC11 deficiency regulates age-related muscle decline and sarcopenia by Renato Odria & Mònica Suelves et al.
https://t.co/FuFJQ8rw2T
#hdac11 #sarcopenia #muscleatrophy #skeletalmuscleregeneration #FattyAcidOxidation

The B.subtilis cluster 2 enzyme, related to class I HDACs, showed promiscuous activity for deacetylation and other PTMs (crotonylation!).
The V.cholerae one from cluster 5, related to #HDAC11, featured its long-chain selectivity and was also explained through a structure🧐.
4/6
Great talk @Robinson7L! Really novel and exciting work regarding #HDAC11 mediated mechanisms in #cardiovasculardisease!
Endocrine Research Conference: @Robinson7L Dr. Emma Robinson discussed work on the role of HDAC11 in fat and heart. Focus on #epigenetic mechanisms in #cardiovascular disease.

AES-135, a hydroxamic acid-based #HDAC inhibitor, prolongs survival in an orthotopic mouse model of #pancreaticcancer. AES-135 inhibits #HDAC3, #HDAC6, #HDAC8, and #HDAC11 with IC50s of 190-1100 nM. #drugdiscovery. https://t.co/nOO0raOeS7

These assays were applied in our #HDAC11 publication @CellChemBiol with @GalleanoIacopo and @StahlMadsen. Their previous experience with similar studies was essential back then, and it keeps being really useful 🧠📈.
Here the original paper:
https://t.co/gO5RrC8jI0
(2/3)
HDAC11 suppression has been known as potential therapeutics for multiple diseases including obesity, cancer and viral infection. Son et al. developed selective HDAC11 inhibitors. #CornellChem @CornellChem #HDAC11 https://t.co/LbzQBp9YhL
Eliminating the #epigenetic modifier #HDAC11 protected mice from #obesity and #insulinresistance https://t.co/0GoNb3dfJI via @brendaLKK


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