Top Tweets for #HDAC8
Congrats to our PhD student Muhammad Murtaza Hassan for successfully defending his thesis on conformationally constrained #HDAC8-selective inhibitors! Murtaza will be moving on to a postdoc in Nathanael Gray's lab @Stanford_ChEMH. Excellent work, and all the best in the future!
AES-135, a hydroxamic acid-based #HDAC inhibitor, prolongs survival in an orthotopic mouse model of #pancreaticcancer. AES-135 inhibits #HDAC3, #HDAC6, #HDAC8, and #HDAC11 with IC50s of 190-1100 nM. #drugdiscovery. https://t.co/nOO0raOeS7
#CHDI-390576, a potent and #CNS penetrant class IIa histone deacetylase (#HDAC) #inhibitor, shows >500-fold selectivity over class I HDACs and ~150-fold selectivity over #HDAC8 and the class IIb #HDAC6 isoform. #drugdiscovery. https://t.co/2VkqmrGRzi
This piece entitled:
I'd rather figure out cure for cancer than work on grant b/c odds seem better"
#glioblastoma #HDAC8 #curcumerin #asparagine #cancer #IDH #juvenileneuroblastoma #lactate #whatamIdoingwithmylife
Our PhD student Murtaza was featured in @TheMediumUTM for his Tetris-inspired discovery of selective #HDAC8 inhibitors! While still in the early stages, Murtaza's molecules show promising antiproliferative activity in #neuroblastoma cancer cells.
https://t.co/s9TKKUuJaq
A new paper in @ChemEurJ by Franz-Josef Meyer-Almes @h_da & Gerald Brenner-Weiss @KITKarlsruhe shows that the #covalent HDAC8 inhibitor PD-404,182 induces the formation of an intramolecular disulfide bond in #HDAC8 resulting in an inactive oxidized form.
https://t.co/YkLykXNmeM
@UofT @UTM Muhammad's unique approach to targeting #HDAC8 in #neuroblastoma has led to some of the most selective HDAC8 inhibitors to date! Check out our @JMedChem article featuring Muhammad's work here:
#medicinalchemistry #drugdiscovery
https://t.co/7M1Zqdq9Kq
Our latest work on the selective targeting of HDAC8 using conformationally constrained benzanilides! Congrats to Murtaza and all fellow co-authors. Lovely use of conformational bias to achieve isozyme selectivity. https://t.co/KP16dvA0lo #DrugDiscovery #MedChem @GunningLabUofT
Congratulations to our PhD student Muhammad Murtaza Hassan for being featured on @UTM News for his "Tetris-based" approach to targeting #HDAC8 selectively!
Read more about his approach here: https://t.co/nM6H1uFdyN
@UTM_CPS #medchem #drugdiscovery
Today is Rare Disease Day!
Alexis and Jessica have taught me so much and I am blessed to be their mom.
Getting the #HDAC8 Deletion diagnosis was a journey but we are there!
#ShowYouAreRare #RareDiseaseDay
@CdLSFoundation #KFStrong @UDNconnect @GoTeamIMPACT
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