Top Tweets for #Highfatdiet
A new piece of evidence of RGS5 in vasculature - more insights & more complexity
#BloodBrainBarrier
Germline RGS5 KO prevents #HighFatDiet-induced BBB leakage (extravascular Fibrinogen) & CD68+ activated Microglia & Spatial memory deficit (Novel location test)
🐭Hippocampus & Striatum IHC
↔️CD13+ Pericyte coverage
↔️Body weight/Glucose tolerance/Insulin tolerance
Which cell types are responsible?🧐
@BrainBehavImm 2026
https://t.co/zn0yVHcV7F
#SIRT6 #VascularCalcification
Rat #HighFatDiet + VitD3 + Nicotine
▶️Aortic medial calcification & ⏬SIRT6
SIRT6 overexpression ⏬Palmitic acid-induced #SmoothMuscleCell Apoptosis & Osteogenesis
#JHyperten 2023
https://t.co/uqISZXnvMW
उच्च बोसोयुक्त आहारले कलेजोका कोशिकालाई क्यान्सरतर्फ धकेल्न सक्ने नयाँ वैज्ञानिक अध्ययनले देखाएको छ। एमआईटीको अनुसन्धानअनुसार लामो समय सम्म यस्तो आहारले कलेजोको संरचना नै परिवर्तन गरी क्यान्सरको जोखिम बढाउँछ।
#HighFatDiet #LiverCancer #LiverHealth
https://t.co/WdAMzHkIeH
High-Fat Diet Triggers Hepatocyte Dedifferentiation and Cancer Risk
#Livercells exposed to a high fat diet revert to an immature state that is more susceptible to cancer-causing mutations
@shaleklab @MIT
#livercancer #highfatdiet
https://t.co/5FZUtpAOPb
#EndothelialCell #MerTK #Efferocytosis #Atherosclerosis
EC MerTK KO🐭+ AAV8-PCSK9 + #HighFatDiet 2-mo
👉⏫lesion burden
👉⏫NADPH oxidase
👉⏫inflamm cytokines
Aortic Arch lesion #Proteomics➡️
⏫TGFβ HIF1α Wnt3a IL2
⏬LARP1 NAMPT TEAD1
Zufeng Ding lab #RedoxBiol 2025
https://t.co/y0ntOn2ZzR
Study warns high-fat keto diet may drive breast cancer risk
https://t.co/ZYr0qqEAVN
#KetoDiet #BreastCancer #HealthStudy #TripleNegativeCancer #ObesityRisks #CancerResearch #HighFatDiet #Wellness #LipidHealth #CancerAwareness
Research Article by E Kallinos et al. (@mplataki @2divyabhatia @WeillCornell @NTU_TW @vib_ccb) #Highfatdiet #obesity exacerbates acute #lunginjury-induced dysregulation of fatty acid oxidation in #alveolar #epithelial type 2 cells
https://t.co/hs0IQ5srVM
Just 4 days of junk food can mess up your memory, cognitive skills: Study
https://t.co/83bBL67p9L
#JunkFood #MemoryLoss #CognitiveSkills #BrainHealth #HighFatDiet #Neuroscience #UNCStudy #Hippocampus #DietAndMemory #IntermittentFasting #PKM2
𝗖𝗵𝗲𝗰𝗸 𝗼𝘂𝘁 𝗼𝘂𝗿 𝗦𝗲𝗽𝘁𝗲𝗺𝗯𝗲𝗿 𝗜𝘀𝘀𝘂𝗲!
🧠Cover Story: β-hydroxybutyrate reduces #highFatDiet-induced impairments in synaptic AMPAR function and cognition - https://t.co/rTkvOD3bcp
🧠Browse the full edition: https://t.co/4J7JBe9wVr
Eat More Fat, Lose More Weight? This Intermittent Fasting Trick Is Shocking Scientists!
#IntermittentFasting #HighFatDiet #EatFatStayLean #FastingBenefits #MetabolicHealth #FlexibleDieting #WeightLoss2025 #ScienceBackedNutrition
https://t.co/Iz0QNL3qAm
mRNA profiles of FGF family 22 ligands + 10 (co)receptors in♂️🐭
Heart Liver Kidney Skeletal muscle Gonadal/s.c. WAT BAT
young 7-wk vs aged 12-mo
-/+ 11-wk #HighFatDiet
Effect of HFD
FGF9 ⏫in BAT, ⏬ in kidney of young, not aged🐭
Effects of #Aging
↔️FGF9
Lots of interesting patterns😆
FGF21 ⏬by HFD or aging in Liver; ⏫by HFD in Heart of aged but not young🐭
#JEndocrSoc 2025 @TheEndoSociety
https://t.co/xRLISzo2mH
📢Latest Open🔓 Access Research Release
Tilorone attenuates high-fat diet-induced hepatic steatosis by enhancing BMP9-Smad1/5/8 signaling by Barnabas Horvath & Aniko Keller-Pinter et al.
https://t.co/7jvofv2rhd
#liver #highfatdiet #metabolicdysfunctionassociatedsteatoticliverdisease
#tilorone #bonemorphogeneticprotein #insulinresistance #mitochondria
Heart #Lymphangiogenesis
Cardiac lymphatic vessel bridges defect #BranchedChainAminoAcid Catabolism with #HeartFailure HFpEF
Rarefaction (~50%⏬) of heart lymphatic vasculature in 👤🐭HFpEF (Hypertension L-NAME + Obesity #HighFatdiet 12 wk)
AAV9-VEGFC in 🐭HFpEF▶️
⏫Diastolic function (⏬E/A E/e' LVEDP)
⏬cardiomyocyte size fibrosis CD68 Mφ
⏬lung congestion
Prox1+ #LymphaticEndothelialCell KO of BCKDK, kinase inactivating BCKDHA (rate-limiting enzyme of BCAA degradation) restored
#Lymphangiogenesis
Diastolic function
🫀pathology
in 🐭HFpEF
Hyperactive Src-mediated lysosomal degradation of VEGFR3 underlies lymphangiogenic defects in vitro caused by BCAA catabolism deficiency (BCKDK OE)
@CircAHA 2025
https://t.co/q72bNdM7gH
🔎Research in focus➡️Hope for the gut: new evidence suggests Western diet damage can be undone (Geetha Bhagavatula and Ian M. Cartwright)
https://t.co/A3qIoKnN6Z
#HighFatDiet #morphology #IntestinalHealth
#HighFatDiet (60% fat w/o extra cholesterol or cholic acid) protects Marfan Aortopathy in♀️, not♂️, mgR/mgR🐭
⏬thoracic aortic diameter
⏬elastin fragmentation
⏬MMP12 Col1a1
↔️proteoglycan
Any benefit on Lifespan or #AorticDissection?😃
#AortaEd
@dkpreinhardt @CJCJournals 2023
https://t.co/6TSgq2RsgG
Any of you carnivores also lick the residue browned butter from your plate?
Or is it just me?
#butterlove #highfatdiet
One Meal A Day: Sirloin Steak & Bone Marrow!
#OMAD #OneMealADay #SirloinSteak #BoneMarrow #KetoDiet #CarnivoreDiet #HighFatDiet #WeightLossJourney #Foodie #SteakLover
"The Higher Your Cholesterol, The Longer You Live."
"If You Have Low Cholesterol, Be Very Afraid."
"The worry over Total Cholesterol & Heart Attack risk is a fallacy from the 60s & 70s."
Dr Jack Wolfson, Board Certified Cardiologist
"Do not fear total Cholesterol, in fact for people older than 60, the higher the total Cholesterol, the longer they live."
The Research Is Clear. The Higher Your LDL, The Longer You Live.
LDL serves an important & vital purpose for vibrant health. LDL contains the antioxidants Vitamin E, CoQ10 & Carotenoids that kill off free radicals. This reduces inflammation & oxidative damage, which are the true causes of cardiovascular disease.
LDL is a transport carrier molecule, is preventive of disease & crucial for our immune system. It is the carrier for all fat soluble vitamins A, D, E & K.
Healthy Cholesterol Is Needed For A Thriving Life:
Prevents dementia & cognitive decline.
Protects against all cause mortality.
Production of all steroid hormones.
Necessary for muscles & bone density.
Protective against stroke & heart disease.
Important for lungs & airways.
Building block of all cells & mitochondria.
Absorption of Vitamins A, D, E & K.
Critical for digestion & bile acids.
Immune system protection against infections.
Lowers risk of cancer & death.
Lowers depression & suicide.
Lowers stress, cortisol & anxiety.
Protects against chemicals, toxins & heavy metals.
A low carbohydrate diet prioritizing nutrient dense animal foods, eliminating harmful seed oils, sugar & processed foods provides the best healthy cholesterol profile.
This approach keeps Triglycerides low & HDL high, which is one of the best Biomarkers for Cardiac health. TG/HDL ratio optimally should be less than 2.0 & even better at 1.5 or less.
👇Higher Cholesterol, Increased Longevity👇
https://t.co/pBrL1yKJ70
👇The Higher Your LDL, The Longer You Live👇
https://t.co/mPAAKc1tZX
👇Low Cholesterol, Higher Risk Of Stroke👇
https://t.co/Znx9snMIPR
Speaker: @DrJackWolfson
This study characterizes de-differentiated #FatCells (DFAT) from different fat depots, exploring their ability to re-differentiate, the impact of #HighFatDiet conditions, and their significance #invivo.
#MetabolicHealth
👩🔬👨🔬@chinese_brain @PKU1898
🔗https://t.co/JFdKDPZOKQ
Female rats on a #highfatdiet have more #muscle lipid infiltration than males. Notably, females had a mix of MHC isoforms, whereas males had only MHC I, in line with the protective role of Type I fibers against muscle lipid buildup.
#MuscleHealth
https://t.co/tuaGpg6Gt4
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