Top Tweets for #ISCSM20
Our very own Rajasree Kundu iPhD student @TIFRScience from Ankona Dattaโs lab gets the best poster prize from @AmerChemSociety. Congratulations ๐๐ฝ๐#ISCSM20
ER exit sites are dynamic, form de novo & can fuse w/ each other in both Pichia & mammalian cells. ER arrival and exit sites are juxtaposed & have coupled dynamics. Dibyendu Bhattacharyya @ACTREC_TMC #ISCSM20
Arf1 regulates golgi size by controlling cisternal maturation rate in S. cerevisiae. Downstream of Arf1, Golgin Pplmh1 mediates reversible cisternal stacking in golgi in Pichia pastoris. Dibyendu Bhattacharyya @ACTREC_TMC #ISCSM20
Read more @J_Cell_Sci: https://t.co/Gc5hRgA6R7
Mahendra Sonawane @TIFRScience says polarity of the bilayered zebrafish epithelium needs aPKC fn for robustness of polarization. Polarity occurs stepwise from the apical cell layer to the basel cell layer & is transduced by E-Cadherin. #ISCSM20
Read more: https://t.co/ArLte8FGZU
Protein-protein interactions are not static but like gears, conformational dynamics are important & lipids matter says @durbignon @csir_ncl #ISCSM20
Computational modeling shows that ErbB growth factor receptors show a large number of conformations that depend on lipids. Cholesterol interactions with GPCRs modulates its hetero-dimerization. @durbignon @csir_ncl #ISCSM20
Read more: https://t.co/7M8RIqh5jv
Butyrate reduces cholesterol levels in mice through miR122. Butyrate prevents invasion of a microbe that can be reversed by cholesterol supplementation. Ends with a poem๐. Moumita Bhaumik @ICMRNICED #ISCSM20
Computational models show that the variants may vary in the way the ligands enter & long range effects on binding sites. The 27Glu variant binds three ligands better thru altered electrostatic interactions. Manali Joshi @UnivOfPune #ISCSM20
Read more: https://t.co/blOlqLhkyT
Personalized medicine necessary due to inter-individual variability that affects pharmacodynamics/kinetics of drugs. Population variants of N-terminus of ฮฒ2AR show differential response to asthma medicine. Manali Joshi @UnivOfPune #ISCSM20
BP regulated through the Renin-angiotensin system through the Angiotensin receptors the target of ARBs. Structure based allosteric drug screens gives potential new BP medication that counteract auto-antibodies against the R. Sadhashiv Karnik @ClevelandClinic #ISCSM20
EGFR is sensitive to environmental stiffness. A single molecule of SOS, a guanine nucleotide exchange factor, arriving kicks off Ras signalling! Assembly that resemble LAT clusters modulate recruitment & mobility. Shalini Low-Nam @PurdueChemistry #ISCSM20
Impulse-response fn: single R events varies in frequency or amplitude thru one or more downstream events to give a response. Maps single molecule Grb2 recruitment dynamics on plasma membrane (PM). Longer dwells of Grb2 on stiff surfaces. Shalini Low-Nam @PurdueChemistry #ISCSM20
Membrane heterogeneity arises from the more than 800 chemically diff lipids. Characterizes membrane lipid nanodomains using MD simulations. Anand Srivastava @iiscbangalore #ISCSM20
Shows that synthetic chloride carrier released by phototriggering can be used for inducing apoptosis selectively of cancer cells. Pinaki Talukdar @iiserpinaki @IISERPune #ISCSM20
Read more: https://t.co/ZvpvkKsVPk
Synthesizes ion carriers & channels (supramolecular) that form co-transporters, exchangers etc to move ions across membranes. Several cause cell death. Pinaki Talukdar @iiserpinaki @IISERPune #ISCSM20
Is the role of water over-rated asks Ananya Debnath, IIT Jodhpur. Interface water can form H bonds with lipid head groups & dynamically facilitates lipid aggregation. Slow water dynamics near surface is universal arises from dynamic heterogeneity. #ISCSM20
Sensing specific signaling lipid that are less than 1% in abundance using membrane crossing reversible turn on fluorescent sensors based on non-covalent interactions. Describes sensitive PIP2 sensors that work in cells. Ankona Datta @TIFRScience #ISCSM20
She models the action of photo-switchable lipids used to control mechanosensitive channels. Movement of lipids to the interface appears critical. Ana-Nicoleta Bondar @FU_Berlin #ISCSM20
Ana-Nicoleta Bondar @FU_Berlin interrogates the graph of protein-H bonds & applies it to ion channels like channelrhodopsin using diff modeling approaches. Membrane transporters that transfer protons often have bulk-exposed carboxylate groups that fn as proton antennas. #ISCSM20
Membrane heterogeneity arises from the more than 800 chemically diff lipids. Characterizes membrane lipid nanodomains using MD simulations. Anand Srivastava @iiscbangalore #ISCSM20
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