Top Tweets for #Inpp5D
This is now online - author version. A new role for SHIP1 in immunity. As mice that lack SHIP1 in their T cells age they develop cancer that originates in the gut. More things to explore.#INPP5D #tumorimmunity

Excited to see the new issue of @ImmunityCP, with our cover @rosa_paolicelli @AnneCompagnion 😍
#microglia #SHIP1 #Inpp5d
New issue online! Cover depicts work from @rosa_paolicelli @Ales_matera @AnneCompagnion &co showing that Inpp5d (SHIP1) is expressed in microglia during early postnatal brain development, where it limits synaptic pruning in a complement-dependent manner. Cover shows microglial cells (magenta) interacting with neurons (cyan) in the mouse CA1 hippocampal region during early development https://t.co/ficS1f1cCV

@ChiaraPedicone and I are thrilled to have been part of this effort! Congratulations to all! #INPP5D #microglia #iPSC Funded in part by @alzassociation
Thrilled to share our latest work on how #SHIP1, a gene linked to #neurodegeneration, affects #microglia in early #brain development. Congrats to @Ales_matera, @AnneCompagnion and the many #collaborators @ImmunityCP @FBM_UNIL
https://t.co/xu8GgsBszu
Yes, I actually am on the faculty at Upstate. A pox on the person who scheduled me as the first talk at the annual biomedical retreat in Skaneateles. Not a morning person. 2 cappuccinos on board. @InnovateUpstate #microglia #Inpp5D #inppl1

Filed in 2019, now issued. #INPP5D

Important study from @AtomwiseInc that showed the power of AI as a viable alternative to high-throughput screening! Read about the largest and most comprehensive virtual HTS campaign to date: https://t.co/iRc6nLxkEg #drugdiscovery #AI #pharma #biotech #INPP5D #SHIP1 #Alzheimers
INPP5D活性低下はNLRP3 inflammasomeの活性化を介しmicrogliaの炎症反応を亢進
さらにIL-1β, IL-18分泌の増加がAβ蓄積と神経変性を惹起
ヒトAD脳組織ではINPP5D活性が低下しinflammasomeが活性化されている
Open Access
#INPP5D
#Alzheimers
#papers
https://t.co/wVmj5DkiPY

Some welcome news on this Thursday. The journey continues. Wonderful collaboration with @rosa_paolicelli and John Chisholm made this possible as well as thesis research from both @ChiaraPedicone & @Ales_matera. #lipidhandling #SHIP1 #INPP5D #microglia #Alzheimers

Alessandro @Alessan13060049 thinking how to convince you that #SHIP1 in #microglia is very important for brain development! #glia2023 go and check his #poster T05-059B on Sunday!! #berlin #glialovers

The final version of our recent work on how SHIPi can control obesity via an innate immune cells is now online. #obesitymedicine #INPP5D #INPPL1 #SHIPi #ILC2 #eosinophils #macrophages
https://t.co/Gb28vr8xf3
Look what just turned up. A mere 8 months after the oral defense. @ChiaraPedicone #INPP5D #INPPL1 #panSHIPi #K161 #K306 #microglia #Alzheimers

Great paper @adrianoblak, @btlamb @Model_ad_alz, et al - important work and target #INPP5D gene #SHIP1 protein - @Treat_ad_alz here is the original article: https://t.co/AIrb2lKQy9

Indiana University School of Medicine researchers @adrianoblak @Peter_BC_Lin are studying how the reduction of a gene variant found in the brain’s immune cells could diminish the risk of late-onset Alzheimer’s disease.
https://t.co/j2aBeoGADb
Successful thesis defense today. Welcome Dr. Chiara Pedicone! @ChiaraPedicone #INPP5D #INPPL1 #microglia #SHIPi #Alzheimers #phdlife
Now online - use of AI to identify novel agonists of the SHIP1 enzyme. Enabled the discovery of a new SHIP1 function - degradation of phagocytosed lipid-bearing cargo. #Alzheimers #INPP5D #K306 @ChiaraPedicone @jdchisho @AtomwiseInc @rosa_paolicelli https://t.co/23NnTCXXMT
Another demonstration of the potential for SHIPi as a cancer therapy. #CLL #INPP5D #SHIPi #cancertherapy https://t.co/i0DZkEVs8n
Paper from Dr. Zhou’s lab at Brown. The role of SHIP1 in mucosal inlfammation gets more complicated and possibly more interesting. ILC2s anyone? #innatelymphocytes #ILC2 #INPP5D https://t.co/SgPMshT8UI
FB reminded me of when we sorted published in Science. Gotta a hat tilt from the editors there. I’ll take that. #SHIPi #INPP5D #stemcells https://t.co/s4aiw65egp
Well, COVID-19 be dammed!! I'm traveling to Germany in ~8 weeks to participate and speak on our research at a Keystone meeting. #INPP5D #SHIP1 #INPPL1 #SHIP2
https://t.co/ucXt6V3HaF @ChiaraPedicone
If you’re in town next week and have some interest. I’m not in charge of the “refreshments”. 😅 #microglia #SHIPi #INPP5D #INPPL1 #Alzheimers #phagocytosis @ChiaraPedicone

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