Top Tweets for #KeedyLab
The #keedylab '024 paper deluge continues! Tamar and I worked with @helen_m_ginn to computationally reveal, model, and analyze 50% more ligand-bound structures that had been lurking unnoticed in our fragment screening data. Here's the @biorxivpreprint: https://t.co/51TqVi4INf
First #keedylab paper of '024! Our paper on "high-resolution double vision" of PTP1B is out now in @ActaCrystF, with some nice improvements over the @biorxivpreprint version. Check it out here: https://t.co/Vq4D8oshbs
๐ New #keedylab Preprint๐ https://t.co/NbUUhZalWd We stumbled upon the highest-res dataset for apo WT PTP1B (n=350 total PTP1B structures @buildmodels). The 2 protein chains have diff degrees of disorder - allowing a direct, controlled comparison of protein conformation(s).
New #keedylab preprint! We ventured out of the crystal lattice and into solution this time. Our favorite protein wiggles & jiggles in surprisingly different ways when bound by a ligand over here vs. over there. Read all about it here: https://t.co/kmPyeT0r9N
Check out our latest #KeedyLab @biorxivpreprint! We compare the effects of physiological temperature vs. high pressure in crystal structures of STEP - a validated therapeutic target for #Alzheimers and #Parkinsons
Coming soon to a journal near you!
https://t.co/5XR1z2GjOi
New #keedylab #preprint! How does a protein structure differ at physiological temp vs. high pressure (vs. traditional cryo temp)? Liliana Guerrero (Margent) & @DrAliEbrahim looked into it: https://t.co/zUcKZiBECj Great collab w/ Qingqiu Huang & Aaron Finke at @MacCHESSCornell !
New #keedylab #preprint! How does a protein structure differ at physiological temp vs. high pressure (vs. traditional cryo temp)? Liliana Guerrero (Margent) & @DrAliEbrahim looked into it: https://t.co/zUcKZiBECj Great collab w/ Qingqiu Huang & Aaron Finke at @MacCHESSCornell !
Kicking off the holiday season early with this unbelievably thoughtful and undeniably awesome gift from the #KeedyLab Secret Santa ๐
๐ผ
You know you want one
@dorbitalgames

We had an invigorating #keedylab journal club meeting this week about this paper by Yabukarski et al. from the Herschlag group: https://t.co/jIllBQ3Ew7 Turns out specific radiation damage is not a big deal for room-temp crystallography, if you do things right! *phew*
Spring 2021 #keedylab news roundup, including new faces, papers, and fellowships: https://t.co/M8bJoYfKXi
Scenes from the first "virtual" iteration of the @asrc_gc Science Cafe! The #keedylab's own @blake_riley regaled us about allostery in tyrosine phosphatases (with a highly appropriate crystallography-themed backdrop). Take that, #COVID19!

@CCNYB3REU fellow Spring Smith researched allosteric inhibitors to the enzyme protein tyrosine phosphatase 1B. Mentored by @CityCollegeNY and @CCNYChem Prof. Daniel Keedy and Maryam Azeem. @GC_BiochemPhD @GC_CUNY @asrc_gc #CCNYB3REU2019 #NSFstories @GCsciences
@CUNYResearch.

The new resident @OpenTrons_ experts in the #keedylab ( @angel_mway and Tamar Skaist) running our first protocol!

If you're at #ACSOrlando, come see me talk about cryptic sites in a dynamic enzyme tomorrow morning, April 3 from 10:50-11:25! I will NOT be cryptic about the site of said talk: room W331A. #allostery #keedylab
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