Top Tweets for #MAZDUTIDE
Mazdutide shows impressive weight loss and waist reduction in a major phase 3 trial for Chinese adults with obesity. Significant cardiometabolic benefits, but GI side effects need attention. 💊📉
https://t.co/ykjQMcKSqb #Mazdutide #Obesity @JAMANetwork

هل نحن أمام منافس جديد يغير قواعد اللعبة في عالم خسارة الوزن؟ 🥊🔥
نتائج مذهلة نُشرت حديثاً في مجلة JAMA لعقار مازدوتيد #Mazdutide (بجرعة 9 ملغ أسبوعياً):
📉 حقق متوسط خسارة وزن مذهل وصل إلى 17% لدى البالغين المصابين بالسمنة، مقارنة بـ 2% فقط لمن تناولوا الدواء الوهمي (Placebo).
🛑 الجانب الآخر: أغلب المشاركين أبلغوا عن أعراض جانبية في الجهاز الهضمي (مثل الغثيان والاضطرابات)، لكنها كانت "خفيفة إلى متوسطة.
الدواء يعتمد على آلية ثنائية متطورة (GLP-1 + Glucagon)، ويبدو أن سباق أدوية الرشاقة يزداد شراسة🧪🧬
ما رأيكم.. هل ستتفوق هذه الأدوية تماماً على جراحات السمنة مستقبلاً؟ 👇
#ADA2026 #صحة #طب #أبحاث_علمية

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#MAZDUTIDE
🇨🇳 #Innovent Biologics' dual glucagon/GLP-1 receptor agonist #mazdutide, has been approved for a new indication for marketing, for glycemic control in adult patients with type 2 diabetes.
Previously, the drug has been approved for long-term weight management in adult patients with obesity or overweight. https://t.co/j40byVUebs
Innovent licensed mazdutide from Eli Lilly.
🇨🇳 #Innovent Biologics announced Friday that #mazdutide, a dual #glucagon/GLP-1 receptor agonist licensed from $LLY in 2019, was approved by Chinese #NMPA for chronic weight management in adults with overweight or obesity. https://t.co/BsccMiRmwo
The decision was based on data from the Chinese Phase III GLORY-1 trial, which were presented #ADA2024 https://t.co/f3hfZ6Ylse At week 32, those taking the high dose saw placebo-adjusted weight loss of 13%, which increased to 14.3% at week 48.
Mazdutide is under NMPA review for type 2 diabetes
In DREAMS-2, the high dose of mazdutide lowered HbA1c by 1.73% from baseline at 28 weeks, versus 1.36% for Trulicity. https://t.co/83O5Pr4f7Z

#Glucagonreceptor #GCGR-based multi-agonist drugs are emerging as promising treatments for #obesity, with several in advanced stages of clinical development.
Agents like #mazdutide, #pemvidutide, #survodutide and #retatrutide
https://t.co/70ON1AXKtp

🇨🇳 #Innovent Biologics announced Friday that #mazdutide, a dual #glucagon/GLP-1 receptor agonist licensed from $LLY in 2019, was approved by Chinese #NMPA for chronic weight management in adults with overweight or obesity. https://t.co/BsccMiRmwo
The decision was based on data from the Chinese Phase III GLORY-1 trial, which were presented #ADA2024 https://t.co/f3hfZ6Ylse At week 32, those taking the high dose saw placebo-adjusted weight loss of 13%, which increased to 14.3% at week 48.
Mazdutide is under NMPA review for type 2 diabetes
In DREAMS-2, the high dose of mazdutide lowered HbA1c by 1.73% from baseline at 28 weeks, versus 1.36% for Trulicity. https://t.co/83O5Pr4f7Z

Once weekly #mazdutide with up to 14% weight loss in a phase 3, double-blind 48-week placebo-controlled trial in China.
https://t.co/GEIIrkgagR

Mazdutide For Obesity
1️⃣ Mazdutide is a dual agonist that activates both GLP-1 and glucagon receptors.
2️⃣ In this new study, after 48 weeks, the average weight change from baseline was:
• Placebo: +0.30%
• 4mg: –11.00%
• 6mg: –14.01%
3️⃣ Discontinuation rates were low:
• 4mg: 1.5%
• 6mg: 0.5%
• Placebo: 1.0%
The future of obesity treatment looks bright 💪
@NutritionMadeS3 @theproof @DrNadolsky @DrKarlNadolsky @drmatthewnagra @MichaelAlbertMd @MichaelMindrum @BevTchangMD
Study Link: https://t.co/8ImHrDLFD5

🇨🇳 #Innovent announces that the results of a Phase 3 clinical study of #mazdutide , a dual GCG/GLP-1 receptor agonist, in Chinese adults with overweight or obesity (GLORY-1) have been published in #NEJM https://t.co/X6JzFnnFZu; https://t.co/x3tmynpVo7
Based on the efficacy estimand, the mean percent change from baseline in body weight was −10.97%, −13.38%, and −0.24% at Week 32 and −12.05%, −14.84%, and −0.47% at Week 48 in the mazdutide 4 mg, 6 mg, and placebo groups, respectively.
A total of 76.3% of participants in the mazdutide 4 mg group and 84.0% in the mazdutide 6 mg group had a weight reduction of ≥5% at week 32, compared with 10.9% in the placebo group; 37.0% of participants in the mazdutide 4 mg group and 50.6% in the mazdutide 6 mg group had a weight reduction of ≥15% at week 48, compared with 2.1% in the placebo group.

🇨🇳 #Innovent $IVBXF registered a Ph3 open-label head to head study (GLORY-3) in #China. The trial aims to compare the efficacy and safety of #Mazdutide versus Semaglutide in overweight or obese patients with MAFLD. /1
Un nuevo medicamento está causando furor luego de que se conociera que puede hacer bajar a quien lo consume casi 20 kilos por año: se trata del #Mazdutide - https://t.co/Ngz9W3shXM
@EliLillyandCo has new blockbuster #obesitymedicine and it isn’t #mounjaro #tirzepatide or #retatrutide! This one is called #mazdutide
#Lilly はどちらを選ぶべきか?
GIP/GLP-1/グルカゴン受容体 #トリプルアゴニスト #LY3437943 は、血糖値と体重減少を示し、GLP-1/グルカゴン受容体の #デュアルアゴニスト #Mazdutide も、ADAで強力なデータを示した。
https://t.co/fq0jNpgpJE
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