Top Tweets for #MONARCHE
Check out this recent @ESMO_Open 📰 on the overall survival with #abemaciclib in early #BreastCancer. This is a primary OS analysis and updated estimates of IDFS and DRFS from the #monarchE trial at a median follow-up of 6.3 years.
🔓https://t.co/hvDjgPPLZJ
@professorSteph7 @BCJoyceO @stolaney1 @delmastro_lucia @JavierCortesMD @hoperugo @ErikaHamilton9 @Prof_Nadia_H

Harold Burstein, MD, PhD (@DrHBurstein) and Sarah Sammons, MD (@drsarahsam) discuss the #monarchE and #NATALEE trials, investigating CDK4/6 inhibitors for high-risk, early stage, HR+ #BreastCancer, which were presented at #ESMO25.
https://t.co/NYAfP6dqiF
Join Dr. Hal Burstein for #BreastCancerBreakthroughs, where he talks with @DanaFarber experts about key #ESMO25 updates. 🎥 In this episode, Dr. Sarah Sammons (@drsarahsam) discusses the #monarchE and #NATALEE trials. Want to hear more about exciting research presented at ESMO? Then register for our free webinar on Nov 14th at 1:30 PM EST!
👉https://t.co/TOvynEyM6g
@DrHBurstein @stolaney1 #BreastCancer #CDK46
9 Breast Ca studies that we touched on with @VKaklamani for #ESMO25:
✅ #monarchE & #NATALEE
✅ #VIKTORIA1
✅ #evERA
✅ #DESTINYBreast: 05/09/11
✅ #ASCENT03
✅ #TropionBreast02
#OncTwitter #MedTwitter @OncUpdates @myESMO @OncoAlert

Breast Ca Highlights from #ESMO25 w/ @VKaklamani!
✅ #monarchE & #NATALEE
✅ #VIKTORIA1
✅ #evERA
✅ #DESTINYBreast: 05/09/11
✅ #ASCENT03
✅ #TropionBreast02
Full Discussion:
- https://t.co/bYNsRGS2hh
- Also on “Oncology Brothers” podcast
#OncTwitter #bcsm
Breast Ca Highlights from #ESMO25 w/ @VKaklamani!
✅ #monarchE & #NATALEE
✅ #VIKTORIA1
✅ #evERA
✅ #DESTINYBreast: 05/09/11
✅ #ASCENT03
✅ #TropionBreast02
Full Discussion:
- https://t.co/bYNsRGS2hh
- Also on “Oncology Brothers” podcast
#OncTwitter #bcsm
Best of #breastcancer news from #ESMO25?
Watch this video and that’ll be enough. We cover all these trials:
Positive
#MonarchE and #NATALEE
#Destiny Breast 11 and DB 05
evera and #VIKTORIA1
#ASCENT03 and #TropionBreast02
#SONIA
https://t.co/l17z2nfG8N
Looking to catch up on major highlights from #ESMO25 with critical commentary but without the hype? Watch this video where I cover the major takeaways from the meeting.
https://t.co/zyMoaCom9o
I discuss these studies-
Breast
Positive
#MonarchE and #NATALEE
#Destiny Breast 11 and DB 05
evera and #VIKTORIA1
#ASCENT03 and #TropionBreast02
#SONIA
GU
Keynote 905
#ALBAN and #POTOMAC
#PSAMAddition
#EMBARK
DV plus Toripalimab
#IMVigor011
Lung
#PAULIEN
Sacituzumab
GI
#Dynamic3
#Matterhorn
#Stellar303
Others
CM 238 and NADINA
RARImmune
#ESMO25 Highlights! Halfway there!
1️⃣ #DESTINY-Breast11
2️⃣ #DESTINY-Breast05
3️⃣ #monarchE
4️⃣ #NATALEE
5️⃣ #VIKTORIA-1
6️⃣ #KEYNOTE905
#MedTwitter #Oncology #OncTwitter #MedX #CommunityOncology #MedEd #bcsm
Read more on top abstract highlights⬇️
https://t.co/vzDJoV8rfU
#monarchE ki-67 analysis by Prof Martin
📍Many patients (3/4) w/ high ki67 up front convert to low after NAC.
💡 Those that convert to low ki-67 have better outcome, but less so than those that are low initially
🔑Benefit of abema regardless of ki-67
#ESMO25 #ESMOAmbassadors

The #OncoalertTopTweet
DAY One #ESMO25
Our🚨Faculty @delmastro_lucia discussing the results of #monarchE #BreastCancer Presentati a #ESMO25 i risultati aggiornati dello studio monarchE che dimostrano come abemaciclib nel trattamento adiuvante delle pazienti con carcinoma mammario ER+ ad alto rischio induce un vantaggio in sopravvivenza globale
#OncoAlertAF
@nataliagandur @acampsmalea @BRicciutiMD
@HHorinouchi @FadiHaddad_MD
@Abdallah81MD @FernandoOnco
@ElisaAgostinett @to_be_elizabeth @bavilima @realbowtiedoc @Erman_Akkus @Lucarecco @GaiaGriguolo @JankovicK
@MarioBalsaMD @DrMirallas @GIMedOnc @OscarTahuahua @UOzkerim @DrRishabhOnco @Onco_Cifu88
@matteolambe @Icro_Meattini
Dear Colleagues at #ESMO25 An honor to introduce our @OncoAlert 🚨Faculty @delmastro_lucia 🇮🇹 discussing the results of #monarchE 🦋 in #BreastCancer
Presentati a #ESMO25 i risultati aggiornati dello studio monarchE che dimostrano come abemaciclib nel trattamento adiuvante delle pazienti con carcinoma mammario ER+ ad alto rischio induce un vantaggio in sopravvivenza globale
@matteolambe @aftimosp @E_de_Azambuja @DrSGraff @jesusanampa @curijoey @ErikaHamilton9 @double_whammied @stage4kelly @coffeemommy @itsnot_pink @maryam_lustberg @IBCResearch @kevinpunie @nicolobattisti @raalbany @hoperugo @teamoncology @stolaney1 @LoiSher @SirohiBhawna @jamecancerdoc @JavierCortesMD @JaniceTNBCmets @Prof_Nadia_H
#OncoAlertAF
@nataliagandur @acampsmalea @BRicciutiMD
@HHorinouchi @FadiHaddad_MD
@Abdallah81MD @FernandoOnco
@ElisaAgostinett @to_be_elizabeth @bavilima @realbowtiedoc @Erman_Akkus @Lucarecco @GaiaGriguolo @JankovicK
@MarioBalsaMD @DrMirallas @GIMedOnc @OscarTahuahua @UOzkerim @DrRishabhOnco @Onco_Cifu88
2. #monarchE: Adj Abemaciclib (approved in Oct 2021) for high risk HR+, LN+ breast cancer, 150mg BID + ET for 2 yrs.
- 7yr IDFS: 77.4% vs. 70.9%
- 7yr DRFS: 80% vs. 74.9%
⭐️ OS: 15.8% ⬇️ risk of death (HR: 0.84). ~2% delta in ITT OS
4/12

Prof. Johnston presents OS for #monarchE
Median f/u 6.3 yrs (all pts off abema 4+ yrs)
👏 we now have OS. 301 vs. 360 deaths - survival 1.8% ⬆️ 7 yrs (was 1% at 5, 1.3% at 6)
Still more 👩🏾 👧🏼 alive with metastatic dz in ET alone
iDFS 6.5% now
#ESMO25 #ESMOAmbassadors

Day 1 #ESMO25 Highlights:
Breast Ca:
1. #POSITIVE 🤰 outcomes
2. #monarchE HR+ Adj Abema
3. #NATALEE HR+ Adj Ribo
Lung Ca:
4. #NorthStar Local Rx in mEGFR
5. #FLAURA2 Chemo + Osi in mEGFR
6. #SOHO01 & #BeamionLung01 HER2+ NSCLC
1/12
#OncTwitter @myESMO @OncUpdates

#ESMO2025 Highlights!
⭐️#monarchE 7-Year Analysis-Adjuvant Abemaciclib+ Endocrine Therapy in High-Risk HR+/HER2- Early Breast Cancer
✅️OS: HR 0.84
✅️7-yr IDFS: 77.4 vs 70.9%
✅7-year IDFS: 77.4 vs 70.9%
🌊 First adjuvant CDK4/6i showing an OS advantage
#MedTwitter #MedX

Fantastic @delmastro_lucia discussing the fresh results from the #MonarchE update 🦋 here in Berlin #ESMO25 🇮🇹
Dear Colleagues at #ESMO25 An honor to introduce our @OncoAlert 🚨Faculty @delmastro_lucia 🇮🇹 discussing the results of #monarchE 🦋 in #BreastCancer
Presentati a #ESMO25 i risultati aggiornati dello studio monarchE che dimostrano come abemaciclib nel trattamento adiuvante delle pazienti con carcinoma mammario ER+ ad alto rischio induce un vantaggio in sopravvivenza globale
@matteolambe @aftimosp @E_de_Azambuja @DrSGraff @jesusanampa @curijoey @ErikaHamilton9 @double_whammied @stage4kelly @coffeemommy @itsnot_pink @maryam_lustberg @IBCResearch @kevinpunie @nicolobattisti @raalbany @hoperugo @teamoncology @stolaney1 @LoiSher @SirohiBhawna @jamecancerdoc @JavierCortesMD @JaniceTNBCmets @Prof_Nadia_H
#OncoAlertAF
@nataliagandur @acampsmalea @BRicciutiMD
@HHorinouchi @FadiHaddad_MD
@Abdallah81MD @FernandoOnco
@ElisaAgostinett @to_be_elizabeth @bavilima @realbowtiedoc @Erman_Akkus @Lucarecco @GaiaGriguolo @JankovicK
@MarioBalsaMD @DrMirallas @GIMedOnc @OscarTahuahua @UOzkerim @DrRishabhOnco @Onco_Cifu88
@OncoAlert 🚨Faculty @delmastro_lucia 🇮🇹 presents updated #monarchE results at #ESMO25 🦋
Abemaciclib improves OS in high-risk ER+ #BreastCancer 💡
Dear Colleagues at #ESMO25 An honor to introduce our @OncoAlert 🚨Faculty @delmastro_lucia 🇮🇹 discussing the results of #monarchE 🦋 in #BreastCancer
Presentati a #ESMO25 i risultati aggiornati dello studio monarchE che dimostrano come abemaciclib nel trattamento adiuvante delle pazienti con carcinoma mammario ER+ ad alto rischio induce un vantaggio in sopravvivenza globale
@matteolambe @aftimosp @E_de_Azambuja @DrSGraff @jesusanampa @curijoey @ErikaHamilton9 @double_whammied @stage4kelly @coffeemommy @itsnot_pink @maryam_lustberg @IBCResearch @kevinpunie @nicolobattisti @raalbany @hoperugo @teamoncology @stolaney1 @LoiSher @SirohiBhawna @jamecancerdoc @JavierCortesMD @JaniceTNBCmets @Prof_Nadia_H
#OncoAlertAF
@nataliagandur @acampsmalea @BRicciutiMD
@HHorinouchi @FadiHaddad_MD
@Abdallah81MD @FernandoOnco
@ElisaAgostinett @to_be_elizabeth @bavilima @realbowtiedoc @Erman_Akkus @Lucarecco @GaiaGriguolo @JankovicK
@MarioBalsaMD @DrMirallas @GIMedOnc @OscarTahuahua @UOzkerim @DrRishabhOnco @Onco_Cifu88
Dear Colleagues at #ESMO25 An honor to introduce our @OncoAlert 🚨Faculty @delmastro_lucia 🇮🇹 discussing the results of #monarchE 🦋 in #BreastCancer
Presentati a #ESMO25 i risultati aggiornati dello studio monarchE che dimostrano come abemaciclib nel trattamento adiuvante delle pazienti con carcinoma mammario ER+ ad alto rischio induce un vantaggio in sopravvivenza globale
@matteolambe @aftimosp @E_de_Azambuja @DrSGraff @jesusanampa @curijoey @ErikaHamilton9 @double_whammied @stage4kelly @coffeemommy @itsnot_pink @maryam_lustberg @IBCResearch @kevinpunie @nicolobattisti @raalbany @hoperugo @teamoncology @stolaney1 @LoiSher @SirohiBhawna @jamecancerdoc @JavierCortesMD @JaniceTNBCmets @Prof_Nadia_H
#OncoAlertAF
@nataliagandur @acampsmalea @BRicciutiMD
@HHorinouchi @FadiHaddad_MD
@Abdallah81MD @FernandoOnco
@ElisaAgostinett @to_be_elizabeth @bavilima @realbowtiedoc @Erman_Akkus @Lucarecco @GaiaGriguolo @JankovicK
@MarioBalsaMD @DrMirallas @GIMedOnc @OscarTahuahua @UOzkerim @DrRishabhOnco @Onco_Cifu88
#ESMO25
OS analysis of #MonarchE trial:
At 6.3 years follow-up, adjuvant abemaciclib +ET
-significantly reduces risk of death (HR 0.842 , p=0.0273)
-Sustained iDFS benefit observed (HR 0.734 p<0.001)
@OncoAlert

Presented at #ESMO25 and simultaneously published in @Annals_Oncology the updated data from #monarchE showing overall survival benefit with addition of #abemaciclib to endocrine therapy in high-risk HR+/HER2- #BreastCancer
@OncoAlert @myESMO @delmastro_lucia #bcsm

Prof. Johnston presents OS for #monarchE
Median f/u 6.3 yrs (all pts off abema 4+ yrs)
👏 we now have OS. 301 vs. 360 deaths - survival 1.8% ⬆️ 7 yrs (was 1% at 5, 1.3% at 6)
Still more 👩🏾 👧🏼 alive with metastatic dz in ET alone
iDFS 6.5% now
#ESMO25 #ESMOAmbassadors

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