Top Tweets for #NFATc1
🚀#RA におけるNFATc1–MTHFD2軸
T細胞は#関節リウマチ（RA）における慢性炎症を駆動しますが、既存治療では病原性T細胞の活性を十分に抑制できない場合があります。
#NFATc1 は直接 #MTHFD2 を活性化し、ワンカーボン代謝を再プログラムすることで、RAにおける炎症性T細胞応答を維持します。
💊MTHFD1/2阻害（#TH9619）：
↓ 炎症性サイトカインの産生
↑ Foxp3⁺ 制御性T細胞
↓ in vivoでの関節破壊
🔬本研究は、NFATc1–MTHFD2転写‐代謝軸が持続的なT細胞炎症の主要因であり、RA治療における有望な代謝標的であることを示しています。
MedChemExpressは本研究で使用された#Tacrolimusおよび#CyclosporinAを提供し、T細胞媒介性炎症経路の研究をサポートしています。
📎https://t.co/2NjErAvTd7
📎https://t.co/Pxwkyx0lxJ
At #ESID2024, @BalKostel presented her research on #NFATC1 deficiency as a model for therapeutic metabolic reprogramming—work started at St. Anna CCRI.
#Scientists from @StAnna_CCRI, #MedUniVienna and @marmara1883 have shown that an inborn #geneticdefect for #NFATC1 leads to an #immunedefect with a disruption of #metabolism in #Tlymphocytes. Antidiabetic drugs normalise the disruption! ➡️ https://t.co/OZ3YPyPfrk
@bloodjournal
🧬🔍Researchers @StAnna_CCRI & @marmara1883 uncovered that an inborn #geneticdefect for #NFATC1 leads to an immune deficiency disrupting immunometabolism. Surprisingly, anti-diabetes medications normalize the disruption! Published in @BloodJournal >>>🔗https://t.co/M4mrHCpube
#Nfatc1 promotes interstitial cell formation during #zebrafish cardiac #valve development! https://t.co/n579BTG9sb
@mpi_mr_hd
The Hinoi lab at @KanazawaUniv describes a LAT1-mTORC1 axis that modulates #NFATc1 in osteoclasts to promote bone homeostasis. https://t.co/sIGJ88VaMJ /scisignal.aaw3921
The Hinoi lab at @KanazawaUniv describes a LAT1-mTORC1 axis that modulates #NFATc1 in osteoclasts to promote bone homeostasis. https://t.co/qjxCVY0xOU
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