Sevgi Kostel Bal

Pediatric immunologist, Postdoctoral researcher @StAnna_CCRI, classics enthusiast #womeninSTEMI, She/her

[Frontiers - Immunology @FrontImmunol]

New Research: Long-term outcome of bone marrow transplantation in NIK deficiency: non-redundant role of non-canonical NF-κB signaling in thymic reconstitution and secondary lymphoid organ development https://t.co/qGsQJQMHvF #FrontiersIn #Immunology

[Sevgi Kostel Bal @BalKostel]

And reporting negative and unexpected results is just as essential as sharing success stories - it’s how our field continues to evolve. #inbornerrorsofimmunity #RareDisease

[Sevgi Kostel Bal @BalKostel]

Our work on long-term transplant outcomes of patients having NIK deficiency is out now! Heartful thanks to all collaborators and to the dedicated clinical team following these patients over 10 years. https://t.co/UQDADBQKvH

[Sevgi Kostel Bal @BalKostel]

BUT another important point here is that, this is not a story of triumph but a humble reflection- a reminder that we as clinicians and scientists, still have much to learn from our patients. Every patient with IEI continues to teach us about human immunology.

[Sevgi Kostel Bal @BalKostel]

Clinical and immunological spectrum of MHC class I deficiency: insights from a long-term cohort: https://t.co/x50TvEl8w2

[St. Anna Children's Cancer Research Institute CCRI @StAnna_CCRI]

Jana Block received the ÖGAI – Fritz & Ursula Melchers Dissertation Prize for her PhD Thesis conducted in the research group of @KaanBoztug at St. Anna CCRI. Her work uncovered germline DOCK11 loss-of-function mutations as the cause of a novel immune dysregulation disorder.

[Sevgi Kostel Bal @BalKostel]

@DailySnoopys I can only draw stickman but a friend made this for me :)

[Acyn @Acyn]

AOC: When I was 16 years old, my dad was diagnosed with a very rare form of cancer. His prognosis was not good. The doctors said that with the treatments they had, their options were limited, but there was an experimental trial. For millions across this country��whose child has a rare disease, whose parent is on death’s door, or who themselves have no treatment options—clinical trials are one of the only ways to extend their lives.

My dad was admitted to that trial, and his cancer went into remission for a brief period. We got two to three more years with him before he eventually passed away. I can tell you that two more years with my dad, three more years with a child, or a lifetime for those saved by NIH’s work—these people don’t think it’s wasteful. They don’t think what’s happening now is acceptable.

[Sevgi Kostel Bal @BalKostel]

@Hatoon_Bkeerah Wow!

[Sevgi Kostel Bal @BalKostel]

2002 Haziran, eski Türkiye’nin son yılı. ⁦@TEDAnkaraMD⁩ #kolejyılları

[Science Magazine @ScienceMagazine]

New research suggests that mutations in #LTBR underlie an inborn error of immunity and lead to defects in secondary lymphoid organ development in humans.

Read more in @SciImmunology: https://t.co/1Xx0339wmD

[Kaan Boztug @KaanBoztug]

Happy to announce the publication of our paper in Science Immunology. Here we describe the first patients with biallelic disease causing mutations in the LTBR gene encoding for the lymphotoxin beta receptor. Thread 1/10
https://t.co/2FHfU0eKSA

[Sevgi Kostel Bal @BalKostel]

It has been an amazing journey from the beginning to end, to delve into the lymphotoxin and lymph nodes. Congratulations to the whole team ⁦@BRansmayr⁩ ⁦@KaanBoztug⁩ ⁦@StAnna_CCRI⁩ , and sincere thanks to all patients and collaborators! https://t.co/NPwoEQCzIk

[St. Anna Children's Cancer Research Institute CCRI @StAnna_CCRI]

Bernhard Ransmayr wrapped up the St. Anna CCRI talks at the #ESID2024 conference with his presentation on a novel immunodeficiency caused by a stromal cell defect, affecting secondary lymphoid organ function.

[St. Anna Children's Cancer Research Institute CCRI @StAnna_CCRI]

Yesterday, @KaanBoztug presented at the plenary session at #ESID2024, sharing insights on the mechanisms of autoinflammation and immune dysregulation in actin-related IEIs! Additionally, Artem Kalinichenko presented his poster on a CRISPR screen on lymphocyte exocytosis pathways.

[Sevgi Kostel Bal @BalKostel]

Was an honor and joy to be there, seeing friends passionate about immunology! #ESID2024

[St. Anna Children's Cancer Research Institute CCRI @StAnna_CCRI]

At #ESID2024, @BalKostel presented her research on #NFATC1 deficiency as a model for therapeutic metabolic reprogramming—work started at St. Anna CCRI.

[Sevgi Kostel Bal @BalKostel]

İmmünyetmezlik hastaları için covid aşısı nereden temin ediliyor acaba? Sağlık personeli olarak artık aşı bulamıyoruz alınmıyor da, hastalarımızı nasıl koruyacağız? @saglikbakanligi

[Sevgi Kostel Bal @BalKostel]

Masterpiece of scientific art!!!!

[Cell Metabolism @Cell_Metabolism]

#NewIssue Ft cover art by Kehuitang Art Studio. He et al. reveal a protective effect of acetate against metabolic and cognitive impairments caused by sleep disruption. Inspired by Monet’s famous Water Lilies paintings, a “mitochondrion” boat drifts in a lotus pond full of water lilies (which, in Chinese, symbolize sleeping beauty in water). Two women sit comfortably in the boat, enjoying tea representing acetate. Their relaxed postures and the harmonious atmosphere suggest that acetate promotes health for individuals suffering from sleep disruption
🔗https://t.co/fCNExqt1q1

[Sevgi Kostel Bal @BalKostel]

Thank you for leaving such a legacy behind, a tribute to Asperger’s lost tribe. Thank you sir for all your understanding and immense support. We are grateful.

[Oliver Sacks Fdn. @OliverSacks]

So saddened to lose the gifted reporter, writer, and human being, Steve Silberman. Steve spent a lifetime using his many talents to help others, to call out abuses of power, and to celebrate the power of music, kindness, and science. He will be sorely missed.
We love you, Steve!