#NSP5 - Twitter Hashtag

about 2 years ago

@JVirology September issue is out! Cover image from Lee, et al. Formation of #NSP5 and #NSP2 #viroplasm-like structures across #rotavirus #species A to J. Related article: https://t.co/rxXNOoSlRF

JVirology's tweet photo. @JVirology September issue is out! Cover image from Lee, et al. Formation of #NSP5 and #NSP2 #viroplasm-like structures across #rotavirus #species A to J. Related article: https://t.co/rxXNOoSlRF https://t.co/76hovNnG5e

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Vipin M. Vashishtha

@vipintukur

about 2 years ago

Researchers isolated SARS-CoV-2 strains, which are drug resistant w/ mutations to #NSP12 protein that is the target of remdesivir & another variant w/ mutations to #NSP5 protein, the target of Paxlovid. 1/

vipintukur's tweet photo. Researchers isolated SARS-CoV-2 strains, which are drug resistant w/ mutations to #NSP12 protein that is the target of remdesivir & another variant w/ mutations to #NSP5 protein, the target of Paxlovid. 1/ https://t.co/F9k8S3lTn7

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Raj Rajnarayanan @RajlabN

over 4 years ago

#SARSCoV2 #Omicron #subvaraints carrying #MainProtease (#MPro) mutations associated with reduced #nirmatrelvir (#Paxlovid) activity | 7/23/22 Top #NSP5 (MPro) mutations: H164N, L50F, G15S, T135I Tracker: https://t.co/I5wXsR1LhY 1/n

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Raj Rajnarayanan @RajlabN

over 4 years ago

SARSCoV2 BA.2 #subvaraints carrying #MainProtease (#MPro) mutations associated with reduced #nirmatrelvir (#Paxlovid) activity Top #NSP5 (MPro) mutations: H164N, G15S, T135I Should investigate if these NSP5 mutations are also associated with Paxlovid rebound. 1/n

RajlabN's tweet photo. SARSCoV2 BA.2 #subvaraints carrying #MainProtease (#MPro) mutations associated with reduced #nirmatrelvir (#Paxlovid) activity

Top #NSP5 (MPro) mutations: H164N, G15S, T135I

Should investigate if these NSP5 mutations are also associated with Paxlovid rebound.

1/n https://t.co/9oxyRIuMRp

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Raj Rajnarayanan @RajlabN

over 4 years ago

#Paxlovid (#Nirmatrelvir) #Rebound - #Clues Is Omicron subvariant w/ main protease #MPro (#NSP5) mutations: G15S or H164N responsible for Paxlovid rebound? Most frequent BA.2* with these mutations: BA.2.3 Most frequent BA.1*: BA.1.1

RajlabN's tweet photo. #Paxlovid (#Nirmatrelvir) #Rebound - #Clues

Is Omicron subvariant w/ main protease #MPro (#NSP5) mutations: G15S or H164N responsible for Paxlovid rebound?

Most frequent BA.2* with these mutations: BA.2.3
Most frequent BA.1*: BA.1.1 https://t.co/7B6OajZAji

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Berta Canal @Berta_Canal

over 5 years ago

#nsp5 #Mainprotease #3CLprotease @TheCrick https://t.co/9DIOn29cL1

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Guido Papa @guidovir_

about 7 years ago

Our first application of the newly developed #Reversegenetics system for #Rotaviruses aimed to shed light on the role of #NSP5 hyperphosphorylation in the assembly of #viralfactories. Fantastic collaboration with @AlexBoRNA https://t.co/xohcC1XwDn

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