Top Tweets for #Mainprotease
Syzygium aromaticum as a possible source of SARS-CoV-2 main protease inhibitors: Evidence from a computational investigation
#SARSCoV2 #COVID19 #Mainprotease
#Inhibitors #Docking
#Moleculardynamicssimulation
https://t.co/lmpR9WigtZ
📌#COVID19 #mainprotease #receptorbasedpharmacophore #moleculardocking #naturalcompounds
New Publication “Receptor-Based Pharmacophore Modeling in the Search for Natural Products for COVID-19 Mpro”
By: Mohd Saeed, et al.
👉https://t.co/qTj6tkM8iZ
#mdpimolecules #NewPublication
Investigation of The Potential Inhibitor Effects of Lycorine on Sars-Cov-2 Main Protease (Mpro) Using Molecular Dynamics Simulations and MMPBSA
Author: Barış Kurt
#MMPBSA #GibbsEnergy #SARSCoV2 #Lycorine #inhibitoreffects #mainprotease #Mpro #3CLpro
https://t.co/TkCh4QRMZo
#HighlyCitedPaper #HighlyAccessedPaper
Title: In Silico Identification and Validation of Organic Triazole Based Ligands as Potential Inhibitory Drug Compounds of SARS-CoV-2 Main Protease
By: Katerina Komrskova , et al.
👉https://t.co/F8RVrYBo0Q
📌#SARS-CoV-2 #mainprotease
Conformational ensemble of SARS-CoV-2 Mpro @IUCrJ https://t.co/ruqA4LfeBE @DiamondLightSou @asrc_gc @GC_CUNY @BrookhavenLab #NSLSII #NVBL @doescience @CCNYChem @GC_BiochemPhD @NIH #proteinstructure #allostery #SARSCoV2 #mainprotease #COVID19 @IUCr #openaccess
Top Circulating SARSCoV2 #Omicron #subvaraints in USA carrying #MainProtease (#MPro) mutations associated with reduced #nirmatrelvir (#Paxlovid) activity
#SARSCoV2 #Omicron #subvaraints carrying #MainProtease (#MPro) mutations associated with reduced #nirmatrelvir (#Paxlovid) activity | 7/23/22
Top #NSP5 (MPro) mutations: H164N, L50F, G15S, T135I
Tracker: https://t.co/I5wXsR1LhY
1/n
This was a big concern I had
#MainProtease mutations that render protease inhibitors like #Paxlovid more ineffective, or useless
Nearly all #BA2 have these
We have not seen such rapid protease mutation in #HIV, for comparison 🤨
SARSCoV2 BA.2 #subvaraints carrying #MainProtease (#MPro) mutations associated with reduced #nirmatrelvir (#Paxlovid) activity
Top #NSP5 (MPro) mutations: H164N, G15S, T135I
Should investigate if these NSP5 mutations are also associated with Paxlovid rebound.
1/n
SARSCoV2 BA.2 #subvaraints carrying #MainProtease (#MPro) mutations associated with reduced #nirmatrelvir (#Paxlovid) activity
Top #NSP5 (MPro) mutations: H164N, G15S, T135I
Should investigate if these NSP5 mutations are also associated with Paxlovid rebound.
1/n
Small-molecule #antivirals, such as these new covalent hybrid inhibitors of #SARSCoV2 #MainProtease, could be an important treatment option against emerging #COVID variants.
@DanielKneller @KovalevskyAY @drmpblakeley @ORNLNeutrons @ILLGrenoble @uthsc @NIDDKgov
Congratulations @CarlssonLab @luttens for what looks like a great #SARSCov2 #MainProtease inhibitor. Do you know when the protein structures will be released?
#SARSCov2 #MainProtease inhibitor from Sweden is potent in cell-based assay & structurally analogous to @covid_moonshot compounds (but with lower MW & no chiral center) #antiviral #COVID19 #MedChem #cheminformatics #DrugDesign
https://t.co/FNEashZEfJ
An Interview With The Team Leader For The Scientific Discovery Of Pfizer’s COVID-19 Drug, Paxlovid https://t.co/3oK24d8Vgz via @forbes
Thank you for recognizing our work @ramadeyrao done through this extremely isolating and difficult year. #COVID19 #GetVaxxed #coronavirus #SARS_CoV_2 #MainProtease #Antiviral #COVID19
A team of researchers in the Jacobs School of Medicine and Biomedical Sciences has developed a new, high-throughput screening method designed to quickly screen antiviral candidates against the SARS-CoV2 virus. #UBuffalo
https://t.co/ejt5VrlZlI
Study suggests efficacy of SARS-CoV-2 main protease inhibitors is not compromised in current COVID-19 variants https://t.co/jpriHEcSIQ @biorxivpreprint @ANUmedia #SARSCoV2 #protease #mainprotease #inhibitor #COVID19 #covid #coronavirus #covidvariant #variantofconcern
$TOMDF Todos Medical Enters into Binding Agreement to Acquire All 3CL Protease Biology-Related Assets and Intellectual Property from NLC Pharma #Tollovir #COVID19 #Omicron #OmicronVariant #3clprotease #3clpro #Mpro #Mainprotease $PFE $MRK $AVIR $CYDY $AMPE https://t.co/cOfU5SmHAi
Protease nsp5/ Mpro highlighted as a promising new therapeutic target against SARS-Cov-2, suggests @Pfizer’s interim data published this month. Read more: https://t.co/iTTYJN2z4t
#mainprotease #COVID19
An Orally Available, Potent designer Small Molecule Inhibitor of SARSCov2 Main Protease, with low off target activity from Pfizer. It has activity against other coronaviruses as well due to 100% homology at the catalytic site. #COVID19 #ProteaseInhibitor #MainProtease
Novel, orally available, SARSCov2 Main Protease Inhibitor from Pfizer as a candidate for all coronavirueses with very low off target effects. #COVID19 #ProteaseInhibitor @pfizer
https://t.co/J8ubxipe9o
Since the beginning of the pandemic, more than 380 #mainprotease structures have been deposited on the PDB @rcsbPDB!🤯 This cotton candy one was rendered by @valentina_VP17 with #ProteinImager https://t.co/ZAsktxCWm2
#structuralbiology
Michaelis-like complex of SARS-CoV-2 main protease @IUCrJ https://t.co/ErnXSrasXm @ORNL @ORNLNeutrons #NVBL @ENERGY @NIDDKgov @NIH #CSMB #COVID19 #SARSCoV2 #3CLprotease #mainprotease #catalytic #C145Amutant #enzymesubstrate @DanielKneller #crystallography @IUCr #openaccess
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