CarlssonLab

Professor, Uppsala University

[CarlssonLab @CarlssonLab]

Are you doing research in Denmark and looking for postdoctoral opportunities?

Have a look at this call from the Novo Nordisk Foundation:
https://t.co/jeR49ZFjDE

contact me if you are interested in applying.

[GPCRmd @GPCRmd]

Bridging NMR and molecular simulations to uncover hidden GPCR dynamics!

Our new study introduces GPCRmd-NMR, combining ML-based NMR predictors and MD simulations to support NMR experiments and reveal GPCR states beyond crystallography.

🔗 https://t.co/GAAUqUdiIP

#GPCR #NMR

[CarlssonLab @CarlssonLab]

Hiring a postdoctoral researcher with expertise in structure-based ligand design, with focus on peptide-binding GPCRs.

https://t.co/3x0kfNWPf1

[CarlssonLab @CarlssonLab]

PhD defense: Let the battle begin!

Alejandro Diaz @shevsea
Marta Filizola @martafilizola

[CarlssonLab @CarlssonLab]

Alejandro Diaz defending his thesis!

[CarlssonLab @CarlssonLab]

@martafilizola visiting Uppsala University today! First presentation of her exciting work on MD simulations of GPCRs, then PhD defense in the afternoon!

@filizolalab1

[CarlssonLab @CarlssonLab]

PhD student Alejandro nailing his thesis!

[CarlssonLab @CarlssonLab]

Carlsson lab BBQ!

[GPCR ECI Zoominar @GPCRzoominar]

📢 GPCR Forum is back after Summer break ☀️
As the first Zoominar after the break, we are hosting @NourKahlous from @CarlssonLab at @uppsalauni on the 27th of August, 4 pm CET.
As always, send a DM to receive the JOIN link or check the @GPCRForum mailing list.

[Mattia Deluigi 👨‍🔬💎 @MDeluigiScience]

We present a structure-based strategy for discovering small molecules targeting peptide-activated receptors.
Applied to neurotensin receptors #GPCRs, it yielded anti-pain compounds https://t.co/DR8orkHyUR
To enable broader application of the strategy, we provide access to...1/x

[CarlssonLab @CarlssonLab]

Read our paper on structure-based design of small-molecule agonists of neurotensin receptors with in vivo analgesic activity:  https://t.co/l2GeHAsC4l

@NatureComms
@uppsalauni
@scilifelab
@ERC_Research

[BryanRoth @zenbrainest]

Very cool paper!
Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity
https://t.co/RvcBHNXLB7

[Nature Reviews Methods Primers @MethodsPrimers]

Recent advances in #peptide-GPCR interactions are transforming drug discovery. This #Primer details experimental and computational approaches, from in silico peptide mining to modern biosensor assays, paving the way for novel therapeutics.
https://t.co/qAaFU6AvgO

[CarlssonLab @CarlssonLab]

Interested in peptide-binding G protein-coupled receptors (GPCRs)?

Have a look at: “Peptide ligand discovery of G protein-coupled receptors”, in Nature Reviews Methods Primers:

https://t.co/bxJbl3bXuz

[JCIM & JCTC Journals @JCIM_JCTC]

Improving AlphaFold2 Performance in Virtual Screens Targeting GPCRs by Enhancing Binding-Site Conformational Sampling #AlphaFold
https://t.co/4jLlcXP2VO
#JCIM Vol66 Issue10 #compchem

[CarlssonLab @CarlssonLab]

Happy to have contributed to this cool paper from the Pål Stenmark group on the molecular mechanisms of DNA-repair by SMUG1. https://t.co/kkLs8fClSB

[CarlssonLab @CarlssonLab]

Nour Kahlous defense has started, and opponent Madan Babu introduces the topic!

[Berkay Selcuk @berkayselcuk]

Great use of comparative genomics to engineer receptors! Stay tuned for our upcoming publication (fingers crossed) investing similar evolutionary hotspots for all human GPCR families.