Top Tweets for #NeoantigenQualityModel
3. Now, prevailing belief ->#PDAC = few mutations = fewer mutation-derived NAs = NAs unlikely #PDAC T cell antigens.
BUT...our #NeoantigenQualityModel(estimates the ~1-2% of immunogenic NAs)
found that long term #PDACsurvivors ∝ more “high quality” NAs ∝longer survival.
@manjuggm Thank you @manjuggm! We focus on #PDAC but we think the concepts in the #NeoantigenQualityModel as demonstrated in this paper could be extended to other cancers as well, including #colorectalcancer.
Definitely worth testing..!
@MaverickNY @Nature Thanks @MaverickNY! Yes, the #NeoantigenQualityModel does factor clonality of mutations (so is the neoantigen in a clone vs. subclone).
We found it interesting that, despite evolving over much longer times, #PDACs in long-term survivors were paradoxically more clonal (Fig. 2a).
And implications for #immunotherapy
#NeoantigenQualityModel could allow rational antigen selection for vaccines (for cancers + possibly other diseases)
What are the implications?
Well, implications for biology
We think the #NeoantigenQualityModel captures the features that the immune system recognizes to preserve the integrity of host genome.
So, take home messages are
1. We think this = evidence that immunoediting occurs in human cancer
(we found it interesting that this is revealed in #PDAC, the classic “immune cold” tumor)
2. Editing targets high quality neoantigens defined by the #NeoantigenQualityModel
With this #NeoantigenQualityModel v2.0, we found that the long-term #PDAC survivors in fact evolved tumors with far fewer high quality neoantigens (arguing for immunoediting)
Interesting..
but are these neoantigens that are not acquired in long-term #PDAC survivors just
any neoantigens/mutations (arguing against immunoediting)
or
immunogenic “high quality neoantigens (arguing for immunoediting)?
So, we developed #NeoantigenQualityModel v2.0…
With #NeoantigenQualityModel v1.0, we showed long-term #PDAC survivors had tumors enriched in high quality neoantigens.
Essentially, that classifying tumors (#PDAC, #lungcancers, #melanomas https://t.co/Sr1nN31aXg) based on “neoantigenicity” correlated with prognosis.
So, in 2017, we proposed our #NeoantigenQualityModel v1.0.
Here, we estimate if a neoantigen is immunogenic based on features of
a. Non-selfness – by neoantigen similarity to known antigens
b. Selfness – by how the neoantigen differentially binds the MHC vs. its wild type
And if we can capture the features that T cells recognize in such errors, through what we called the “#NeoantigenQualityModel”, we could both understand the underlying biology and potentially apply it in therapies (eg: rationally select antigens for vaccines).
Last Seen Hashtags on Sotwe
cumonmum
Seen from Latvia
omegle() +filter:videos
Seen from United States
chudai
Seen from Saudi Arabia
omegle()+filter:native_video
Seen from United States
kgyn
Seen from United States
NOlimit filter:videos
Seen from Brazil
momsonn filter:videos
Seen from Canada
momson momson+videos
Seen from Turkey
koreanporn
Seen from Indonesia
xlii or #exny or #momson or #nolimit() +filter:native_video
Seen from Turkey
Most Popular Users
Elon Musk 
@elonmusk
241.5M followers
Barack Obama
@barackobama
119M followers
Cristiano Ronaldo
@cristiano
113.8M followers
Donald J. Trump
@realdonaldtrump
111.8M followers
Narendra Modi
@narendramodi
107.2M followers
Rihanna
@rihanna
98.6M followers
NASA
@nasa
92.4M followers
Justin Bieber
@justinbieber
91.7M followers
KATY PERRY
@katyperry
89.6M followers
Taylor Swift
@taylorswift13
83.6M followers
Lady Gaga
@ladygaga
75M followers
Virat Kohli
@imvkohli
72.8M followers
Kim Kardashian
@kimkardashian
70.7M followers
YouTube
@youtube
68.8M followers
Neymar Jr
@neymarjr
65.8M followers
Bill Gates
@billgates
64.9M followers
Selena Gomez
@selenagomez
62.7M followers
The Ellen Show
@theellenshow
62.3M followers
CNN
@cnn
61.8M followers
X
@x
60.7M followers