Top Tweets for #Nk_cell
#immunotherapy #ImmunityBio #NK_cell #IL15 $IBRX
🦉IL-15 has reached the clinic. Now the challenge is controlling it.
For years, IL-15 looked almost ideal for cancer immunotherapy. It expands NK cells and cytotoxic CD8⁺ T cells, supports memory, and avoids some of the biological liabilities of IL-2.
The problem was never whether IL-15 could activate immunity. It was how to make that activation persistent enough to matter without turning a potent cytokine into a systemic toxicity problem.
ImmunityBio’s ANKTIVA, or N-803, is the clearest proof that this problem can be partly engineered around. Rather than administering native IL-15, N-803 combines an affinity-enhanced IL-15 mutant with IL-15Rα/Fc, mimicking the receptor-associated form in which IL-15 naturally works. It is now the first and only FDA-approved IL-15-based immunotherapy, used with BCG in BCG-unresponsive NMIBC.
But that approval may be more important biologically than commercially. It validates IL-15 as a druggable immune axis in humans.
The field is already moving to the next problem. Longer-lived IL-15 can also mean broader systemic exposure. Chronic stimulation can produce inhibitory feedback, alter NK-cell function, and increase toxicity.
That is why newer strategies are trying to control not just the strength of IL-15 signaling, but its location and timing—by attaching IL-15 to checkpoint antibodies, concentrating it inside tumors, or engineering CAR-T, CAR-NK and CAR-iNKT cells to produce it locally. Frontiers
So ANKTIVA may represent the first successful generation of IL-15 engineering, not the endpoint.
The question has shifted from “Can IL-15 work in cancer?” to “How precisely can we decide where, when and in which immune cells IL-15 is allowed to work?”
https://t.co/hSxYeGoNEY
The transcription factor CREM is a pivotal regulator of #NK_cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies b…
https://t.co/K99aMGSAJf
One example of many emerging NK cell-mediated regulatory roles in constraining T cell immunity against cancer. @SciImmunology #NK_cell https://t.co/udrouXTBPp
Researchers @TRIMMprogram and TILT Biotherapeutics Ltd et al. presenting allogeneic #NK_cell #therapy with an #oncolytic #adenovirus for the treatment of human #OvCa. @EKerkela @Veripalvelu collaborating!
https://t.co/dTFcIvc2Kd #bloodserviceresearch
Helka Göös @Veripalvelu presenting her poster "Transduction of human primary NK cells with lentiviral vectors" in #LIONconf23 the Leipzig Immune ONcology Conference. #Immunotherapy #NK_cell #CellTherapy #bloodserviceresearch
I was honored to be selected to present our work on cytokine networks in NK cells at the NK cell satellite symposium of the @dgfi_org meeting today. Great session, with diverse and exiting talks on NK cell biology and wonderful kick-off for the conference!😃 #Nk_cell
3/N "... decrease in #NK_cell function that accompanies physiological ageing is likely to have wider implications for the health of older adults than originally thought."
https://t.co/sqvT9dq7jp
#NK_cell Function | Gab3 is required for IL-2– and IL-15–induced NK cell expansion | #antiTumor Responses and limiting trophoblast invasion during #Pregnancy | Kasper Hoebe @JanssenUS @SciImmunology https://t.co/vdovCGEFoj
#NK_cell Function | Gab3 is required for IL-2– and IL-15–induced NK cell expansion | #antiTumor Responses and limiting trophoblast invasion during #Pregnancy | Kasper Hoebe @JanssenUS @SciImmunology https://t.co/vdovCGEFoj
#NK_cell Function | Gab3 is required for IL-2– and IL-15–induced NK cell expansion | #antiTumor Responses and limiting trophoblast invasion during #Pregnancy | Kasper Hoebe @JanssenUS @SciImmunology https://t.co/vdovCGEFoj
📣 New Podcast! "How does Checkpoint Inhibitor Therapy Work when there’s no Checkpoint Expressed on a Patient's Cancer" on @Spreaker #cancer #checkpoint #immune #inhibitor #nk_cell https://t.co/CeMRCNY93Q
#NK_Cell production, expansion, and life histories at a clonal level | Model for NK cell homeostasis and regeneration | Cynthia Dunbar @NIH @SciImmunology https://t.co/igSRQ1GiCE
#NK_Cell production, expansion, and life histories at a clonal level | Cluster Tracking of Barcodes over time | Cynthia Dunbar @NIH @SciImmunology https://t.co/igSRQ1GiCE
#NK_Cell production, expansion, and life histories at a clonal level | Clonal Bias of CD56-CD16+ NK Cell subpopulations | Cynthia Dunbar @NIH @SciImmunology https://t.co/igSRQ1GiCE
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