Top Tweets for #OneYearinJExBio
Finally, A. Yamamoto et al developed a rapid, highly sensitive sEV quantification method to identify compounds that showed significant and dose-dependent changes in gLuc-reporter activity (sEV production) with minimal cytotoxicity. https://t.co/2bzZA0ecyC #OneYearinJExBio
And @ColinHisey et al showed that breast cancer cell lines and subtypes can be cultured simultaneously in space, resource, and time efficient manner using CELLine AD 1000 systems, allowing consistent production of vast amounts of EVs.
https://t.co/2bzZA0ecyC #OneYearinJExBio
September 22 in #JExBio, @laurenewman13 et al developed & validated a targeted LC-MS/MS assay for the quantification of #EV markers in human blood. It's highly sensitive, quantitative and high throughput and only requires a small sample. 📖https://t.co/2bzZA0ecyC #OneYearinJExBio
You can find all of these manuscripts and more in our celebratory virtual issue #OneYearinJExBio – take a look 👉 https://t.co/67n2GK5o07 #OneYearinJExBio
And finally, August 2022 brought us work from @NikitaKarra, @the_milk_EV_guy et al showing that #EVs from human milk preserve bronchial epithelial cell barrier under inflammatory conditions. https://t.co/67n2GK5o07 #OneYearinJExBio
We published a side-by-side comparison of 2 commercially available digital instruments: the SP-IRIS and the SiMoA platform. Scientists from @MarinaCretich’s lab concluded different instruments may better suit clinical vs research settings. https://t.co/2bzZA0ecyC #OneYearinJExBio
Takahiro Ochiya’s lab showed that high-grade bladder cancer cells secrete #EVs containing miR-146a-5p that contributes to cancer progression by promoting angiogenesis. Suggesting miRNAs in EVs may become a target molecule for therapy. https://t.co/2bzZA0ecyC #OneYearinJExBio
Lots to talk about from #JExBio in August 22! This study from Helen Sheldon et al reported on a significant⬆️in vesicular ELTD1 in the plasma of patients with #preeclampsia revealing its potential as a #biomarker of vessel dysfunction. https://t.co/2bzZA0ecyC #OneYearinJExBio
So much potential when it comes to #EVs and #biomarkers! Looking back on 2022 when Mercedes Tkach et al published work showing that circulating #EVs provide valuable protein, but not DNA, biomarkers in metastatic breast cancer. Read it 👉https://t.co/2bzZA0ecyC #OneYearinJExBio
This great review is for anyone interested in #EVs for translational research. The Le lab provides an overview of composition, biogenesis, functions, and clinical translation of circulating nanoparticles in blood from bench to bedside https://t.co/2bzZA0ecyC #OneYearinJExBio
And this report in July ‘22 on palmitoylation as a novel regulator of #EV formation and function during sepsis indicates that blocking palmitoylation can reduce sepsis-stimulated production of complement-enriched EVs https://t.co/2bzZA0ecyC #OneYearinJExBio
Interested in the #TME? Well, these data published in #JExBio in July 2022 demonstrate that the enzyme QSOX1 may have more influence on the tumour microenvironment than generally appreciated. 👉 https://t.co/2bzZA0ecyC #OneYearinJExBio @CatInScience, @lab_slater, @GleghornLab
In June 2022 Martin Auber and Per Svenningsen from @SyddanskUni provided us with an estimate of #EV secretion rates of human blood cells. Their analysis indicates that cell-specific mitochondrial metabolism can cause ⬆️ EV secretion rates. https://t.co/2bzZA0ecyC #OneYearinJExBio
It's time to revisit the #exomere and #supermere exchange between @labwitwer and @Coffey_EGFR from June 2022 in #JExBio! If you haven't read these, make that something you do! Find them both here 👉https://t.co/2bzZA0ecyC #OneYearinJExBio
And finally we had this great work from Anne Boruo et al looking at #helminth #EVs. They compare the separation methods of SEC and UC finding that a combination approach does present with slightly higher purity than either method alone #OneYearinJExBio 👉 https://t.co/2bzZA0ecyC
Let's look back at May 2022, first up, we had this great article from Jenna Morris-Love et al showing that several overlapping intracellular pathways are responsible for the biogenesis of JC polyomavirus containing #EVs. #OneYearinJExBio Read it here 👉https://t.co/2bzZA0ecyC
Interested in knowing more about #RNA cargo in #EVs? Then this review from @LizzieDellar et al published in #JExBio in May 2022 could be just what you are looking for! Find it here👉 https://t.co/2bzZA0ecyC #OneYearinJExBio @ClaireHill_ @DrMelling @DaveCarter1234 @CaspaseLab
Looking again at April '22, Peng et al from @ChildrensLA shared their work on #EVs in the aqueous humour, revealing eye-specific CD63-dominant subpopulations that could potentially be used to monitor successful tumor response to therapy #OneYearinJExBio👉https://t.co/2bzZA0ecyC
In April 22 @KevinYim3 from @rclaboratory proposed #EVs from #liquidbiopsies as a diagnostic and prognostic tool for COVID-19. Profiling of immune EVs, with SARS-CoV-2 Spike S1+ EVs, provided a novel signature for SARS-CoV-2 infection. #OneYearinJExBio 👉https://t.co/2bzZA0ecyC
April 2022, Yubo Wang et al pointed to a possible mechanism of AnxA6 translocation in #matrixvesicles from the surface of the internal leaflet into the phospholipid bilayer upon lumen acidification during formation of apatite. Read it👉https://t.co/2bzZA0ecyC #OneYearinJExBio
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