#Orf9b - Twitter Hashtag

4 days ago

SARS-CoV-2 has another mitochondrial “trick”—and researchers are trying to block it. ➡️ The viral protein #ORF9b binds to #TOM70, a #mitochondrial protein that helps trigger the cell’s type-I interferon antiviral response. By interfering with this pathway, ORF9b can help the virus dampen the host’s early immune defence. 1/

vipintukur's tweet photo. SARS-CoV-2 has another mitochondrial “trick”—and researchers are trying to block it.

➡️ The viral protein #ORF9b binds to #TOM70, a #mitochondrial protein that helps trigger the cell’s type-I interferon antiviral response.

By interfering with this pathway, ORF9b can help the virus dampen the host’s early immune defence. 1/

4

161

51

62

5K

Raj Rajnarayanan @RajlabN

about 3 years ago

#ICYMI #SARSCoV2 #ORF9b requires due attention H/T @LongDesertTrain

Ryan Hisner @LongDesertTrain

about 3 years ago

How important is ORF9b? More important, I think, than almost anyone has realized. ORF9b is often neglected—it is ignored on phylogenetic trees & on GISAID sequences. I see 9 lines of evidence indicating it's a major player. But they require some background. /1

LongDesertTrain's tweet photo. How important is ORF9b? More important, I think, than almost anyone has realized. ORF9b is often neglected—it is ignored on phylogenetic trees & on GISAID sequences. I see 9 lines of evidence indicating it's a major player. But they require some background. /1 https://t.co/PPLpzZEmrb

21

535

156

243

230K

0

17

6

1

1K

Shira Weingarten-Gabbay @WeingartenShira

over 3 years ago

So, what about non-canonical ORFs? We found peptides from #ORF9b and #ORF3c, revealing for the first time the contribution of internal ORFs to HLA-II peptides. As a side note, immunopeptidomics is a great tool to detect non-canonical proteins, often missed by proteome MS (ORF3c).

WeingartenShira's tweet photo. So, what about non-canonical ORFs? We found peptides from #ORF9b and #ORF3c, revealing for the first time the contribution of internal ORFs to HLA-II peptides. As a side note, immunopeptidomics is a great tool to detect non-canonical proteins, often missed by proteome MS (ORF3c). https://t.co/UPyWBG7g22

2

16

0

1

824

Chase W. Nelson 倪誠志 @chasewnelson

over 5 years ago

@Shawn77an @lucygthorne @NCBI @eLife @zachary_ardern @sokolokot @chkuo1995 Interesting question! The #Alpha (B.1.1.7; UK) mutations likely arose in a patient with long-term COVID-19. The overlapping gene #ORF9b was already present in all members of the species of SARS-CoV and SARS-CoV-2. See Figure 1 of our @elife paper ⬇️ ➡️https://t.co/5q1kDWghkp

chasewnelson's tweet photo. @Shawn77an @lucygthorne @NCBI @eLife @zachary_ardern @sokolokot @chkuo1995 Interesting question! The #Alpha (B.1.1.7; UK) mutations likely arose in a patient with long-term COVID-19. The overlapping gene #ORF9b was already present in all members of the species of SARS-CoV and SARS-CoV-2. See Figure 1 of our @elife paper ⬇️ ➡️https://t.co/5q1kDWghkp https://t.co/T8xfyCucwG

0

3

1

0

Chase W. Nelson 倪誠志 @chasewnelson

over 5 years ago

A new report by @lucygthorne suggests the high transmissibility of SARS-CoV-2 #Alpha (B.1.1.7) involves the gene #ORF9b. 🔗https://t.co/e7qaqW35Pf ORF9b is an #OverlappingGene (#OLG)—a gene within a gene—shown below. As of now, no OLGs are annotated in the @NCBI reference genome.