Top Tweets for #PAINSCIENCE

European Rolfing® Association (ERA) @EURolfingAssoc

3 days ago

What influences a person's experience of pain? Explore current pain science in an 8-week online course from Science of Somatics. 📅 Starts 27 Oct 2026 https://t.co/Pri590XcKh #Rolfing #PainScience

Dr. Caleb Slater @TheSpinalTruth

4 days ago

Your MRI is lying to you – just because it shows something doesn’t mean it’s causing your pain! Check out my arm treatment course at https://t.co/2JCc3CHp5c #MRI #PainScience #PhysicalTherapy #SpineHealth #InjuryRecovery #MoveBetter

Knowledge Galaxy | Health & Beauty Care | Tips @KnowladgeGalaxy

5 days ago

What Happens When You Stub Your Toe? 🦶😖#StubbedToe #HumanBody #BodyFacts #HealthFacts #PainScience #MedicalFacts #ScienceFacts #DidYouKnow #WellnessTips #KnowledgeGalaxy

South Louisiana Wellness Center @SOLA_Wellness

6 days ago

Hurt is the sensation your brain produces. Harm is structural damage. They're not the same thing. Your pain can be 100% real while your tissue is 100% safe. #ChronicPain #PainScience

Hypermobility MD: Dr Linda Bluestein @BluesteinLinda

20 days ago

Can your expectations actually change how your brain experiences pain? On this week's episode of Bendy Bodies, we discuss research showing that expectations can influence how the brain processes pain. #ChronicPain #PainScience #Neuroscience #HypermobileEDS #BendyBodiesPodcast

484

NewMind Tech @NewMindTech

about 2 months ago

Pain can persist when the brain detects a mismatch between body signals and expectations. This doesn't mean the pain is imaginary: It means the nervous system may still be in protection mode, even after the original threat has changed. #PainScience #Neuroscience #BrainHealth

NewMindTech's tweet photo. Pain can persist when the brain detects a mismatch between body signals and expectations.

This doesn't mean the pain is imaginary: It means the nervous system may still be in protection mode, even after the original threat has changed.

#PainScience #Neuroscience #BrainHealth https://t.co/4fqi33rcZy

Andrea D. Furlan MD PhD PM&R @adfurlan

3 months ago

Ziru’s project at KITE Research Institute is to develop and test an AI-enabled, clinician-supervised Brain Rewiring Application for people with #ChronicPain Join me in welcoming Dr. Ziru Wang to Canada!🇨🇦 #CanadaLeads #UHN #AI #PainScience #Neuroscience #BrainScience

adfurlan's tweet photo. Ziru’s project at KITE Research Institute is to develop and test an AI-enabled, clinician-supervised Brain Rewiring Application for people with #ChronicPain

Join me in welcoming Dr. Ziru Wang to Canada!🇨🇦

#CanadaLeads #UHN #AI #PainScience #Neuroscience #BrainScience https://t.co/o47BDAjYYO

154

Hypermobility MD: Dr Linda Bluestein @BluesteinLinda

3 months ago

Pain doesn’t stay in one place 💬 Have you ever treated one area and noticed relief somewhere else? #BendyBodies #ChronicPain #Hypermobility #PainScience #Substack

BluesteinLinda's tweet photo. Pain doesn’t stay in one place

💬 Have you ever treated one area and noticed relief somewhere else?

#BendyBodies #ChronicPain #Hypermobility #PainScience #Substack https://t.co/SfYhuNNtFr

203

Kathleen Sluka @ksluka0101

4 months ago

TENS reduces movement-pain and fatigue in fibromyalgia in a real-world setting. We show clinically meaningful changes with moderate effect sizes. Continues to work at 6 months, with 80% of people still using. #painscience #fibromyalgia @UIowaPTRS https://t.co/ZGYR2EHm7K

721

د.فارس العضيبي | Faris Alodaibi @farispt

4 months ago

نستثمر في كورسات التكنيك لكن نتجاهل... كيف نفكر؟ كيف نتواصل؟ كيف نبني علاقة مع المريض؟ هذه "المهارات غير السريرية" نادرًا تُحتسب في التعليم المستمر Clinician النتيجة: معالج تقني… وليس https://t.co/9pYBlSgh1v #PhysicalTherapy #PainScience #EBP

د.فارس العضيبي | Faris Alodaibi @farispt

4 months ago

أكبر خطأ في علاج الألم المزمن: التركيز على الألم فقط. أكبر نجاح: تحسين حياة المريض even if pain remains Pain and Function in Chronic Musculoskeletal Pain—Treating the Whole Person https://t.co/AY8UvjPzA6 #ChronicPain #PainScience #Biopsychosocial #Rehabilitation #Physiotherapy

ترياق @tiriaqq

5 months ago

أخصائي علاج طبيعي؟ كيف تشرح للمريض مفهوم Centralized Pain بطريقة يفهمها في دقيقتين؟ هذه 3 جمل + رسم توضيحي بسيط يغير نظرة المريض لألمه المزمن (جاهز للطباعة أو الواتساب) https://t.co/FO5r6VNyVf #ألم_مزمن #PainScience #علاج_طبيعي

Tonix Pharmaceuticals @TonixPharma

5 months ago

We recently presented data from the Phase 3 RESILIENT trial of our approved fibromyalgia medicine at the @AmerAcadPainMed PainConnect 2026 Annual Meeting. Read more: https://t.co/h80cBOE2Uk #PainConnect2026 #Fibromyalgia #ChronicPain #NonOpioid #PainScience #Tonix

TonixPharma's tweet photo. We recently presented data from the Phase 3 RESILIENT trial of our approved fibromyalgia medicine at the @AmerAcadPainMed PainConnect 2026 Annual Meeting. Read more: https://t.co/h80cBOE2Uk

#PainConnect2026 #Fibromyalgia #ChronicPain #NonOpioid #PainScience #Tonix https://t.co/pCj6Nb00mi

638

Sports Therapists @TheSSTofficial

5 months ago

Why women’s pain still isn’t believed, and why it matters for every Sports Therapist. Women describe pain differently. Women endure pain longer. Women have their pain dismissed more often. Read the full blog in the CPD area. #IWD2026 #PainScience #EndometriosisAwareness

TheSSTofficial's tweet photo. Why women’s pain still isn’t believed, and why it matters for every Sports Therapist.

Women describe pain differently. Women endure pain longer. Women have their pain dismissed more often.

Read the full blog in the CPD area.

#IWD2026 #PainScience #EndometriosisAwareness https://t.co/G5xe9MXK40

115

Dr.Kartik Sonawane

@KartikBSonawane

5 months ago

👁️🔬Seeing Is Not Knowing: Why Sensory Fibers Escape the Naked Eye in Cadaveric Studies #RegionalAnesthesia #PainMedicine #Anatomy #Neuroanatomy #Periosteum #BonePain #MedEd #FOAMed #AnesthesiaTwitter #MedicalEducation #NerveAnatomy #PainScience #TipOfTheDay #MyRATips Tip of the Day: 📌 Many anatomical claims today are made based on what is visible during cadaveric dissection. 📌 But an important question must be asked: ➡ Can the naked eye truly see the structures responsible for sensory transmission? 🔴 🧠 MICROSCOPIC REALITY (Nerve Fibers) 📌 Nerve Fiber Diameters ▪ Aα fibers → 12–20 µm ▪ Aβ fibers → 5–12 µm ▪ Aγ fibers → 3–6 µm ▪ Aδ fibers → 2–5 µm ▪ B fibers → <3 µm ▪ C fibers → 0.4–1.3 µm ➡ Even the largest axon is only ~0.02 mm in diameter. 🟣 🔬 WHAT WE ACTUALLY SEE DURING CADAVERIC DISSECTION? 📌 Visible structures ✔ Nerve trunks ✔ Fascicles ✔ Gross branching patterns 📌 These structures measure millimeters, not microns. ➡ What we see is a bundle of thousands of microscopic axons, not the individual sensory fibers themselves. 🟢 ⚡ WHY SENSORY FIBERS CANNOT BE SEEN 📌 Size limitation: Individual sensory axons are microscopic structures far below the resolution of the naked eye. 📌 Post-mortem changes: ▪ Collapse of microvascular-neural networks ▪ Degeneration of delicate unmyelinated fibers 📌 Fiber composition: Many sensory fibers (especially C fibers) are unmyelinated and extremely thin, making them almost impossible to visualize grossly. ➡ Therefore: Sensory fibers cannot be identified in CADAVERIC exploration using naked-eye observation. 🟠 🌐 THE HIDDEN NEURAL WEB 📌 Sensory fibers rarely travel alone Instead they form dense microscopic networks or plexuses over richly innervated structures such as: ✔ Periosteum ✔ Skin ✔ Fascia ✔ Joint capsules ✔ Ligaments 📌 These networks create fine plexiform neural meshes rather than thick visible nerves. ➡ This is why many highly sensitive tissues appear “nerve-free” in gross dissection, despite being neuroanatomically rich. 🔵 🔬 HOW THESE FIBERS ARE ACTUALLY IDENTIFIED Detection requires modern scientific methods, including: ✔ Histological microscopy ✔ Electron microscopy ✔ Immunohistochemistry ✔ Neurochemical markers (Substance P, CGRP, etc.) ✔ Neurotracing techniques ➡ These techniques reveal neural networks invisible to gross anatomy. 🧠 ⚡ KEY ANATOMICAL INSIGHTS 📌 Absence in gross dissection does not equal absence in anatomy. 📌 Cadaveric observation alone cannot define microscopic neural architecture. 📌 Many sensory systems are revealed only through histological and molecular methods. 🔴 🚀 TAKE HOME ✅ Sensory fibers cannot be identified with the naked eye. ✅ They form microscopic plexiform networks over highly innervated tissues. ✅ Modern microscopy-not gross dissection-is required to reveal them. ➡ Confusing “NOT SEEN” with “NOT EXISTING” risks replacing science with assumption.

KartikBSonawane's tweet photo. 👁️🔬Seeing Is Not Knowing: Why Sensory Fibers Escape the Naked Eye in Cadaveric Studies

#RegionalAnesthesia #PainMedicine #Anatomy #Neuroanatomy #Periosteum #BonePain #MedEd #FOAMed #AnesthesiaTwitter #MedicalEducation #NerveAnatomy #PainScience #TipOfTheDay #MyRATips

Tip of the Day:

📌 Many anatomical claims today are made based on what is visible during cadaveric dissection.

📌 But an important question must be asked:

➡ Can the naked eye truly see the structures responsible for sensory transmission?

🔴 🧠 MICROSCOPIC REALITY (Nerve Fibers)

📌 Nerve Fiber Diameters

▪ Aα fibers → 12–20 µm
▪ Aβ fibers → 5–12 µm
▪ Aγ fibers → 3–6 µm
▪ Aδ fibers → 2–5 µm
▪ B fibers → <3 µm
▪ C fibers → 0.4–1.3 µm

➡ Even the largest axon is only ~0.02 mm in diameter.

🟣 🔬 WHAT WE ACTUALLY SEE DURING CADAVERIC DISSECTION?

📌 Visible structures
✔ Nerve trunks
✔ Fascicles
✔ Gross branching patterns

📌 These structures measure millimeters, not microns.

➡ What we see is a bundle of thousands of microscopic axons, not the individual sensory fibers themselves.

🟢 ⚡ WHY SENSORY FIBERS CANNOT BE SEEN

📌 Size limitation:
Individual sensory axons are microscopic structures far below the resolution of the naked eye.

📌 Post-mortem changes:
▪ Collapse of microvascular-neural networks
▪ Degeneration of delicate unmyelinated fibers

📌 Fiber composition:
Many sensory fibers (especially C fibers) are unmyelinated and extremely thin, making them almost impossible to visualize grossly.

➡ Therefore:
Sensory fibers cannot be identified in CADAVERIC exploration using naked-eye observation.

🟠 🌐 THE HIDDEN NEURAL WEB

📌 Sensory fibers rarely travel alone
Instead they form dense microscopic networks or plexuses over richly innervated structures such as:
✔ Periosteum
✔ Skin
✔ Fascia
✔ Joint capsules
✔ Ligaments

📌 These networks create fine plexiform neural meshes rather than thick visible nerves.

➡ This is why many highly sensitive tissues appear “nerve-free” in gross dissection, despite being neuroanatomically rich.

🔵 🔬 HOW THESE FIBERS ARE ACTUALLY IDENTIFIED

Detection requires modern scientific methods, including:
✔ Histological microscopy
✔ Electron microscopy
✔ Immunohistochemistry
✔ Neurochemical markers (Substance P, CGRP, etc.)
✔ Neurotracing techniques

➡ These techniques reveal neural networks invisible to gross anatomy.

🧠 ⚡ KEY ANATOMICAL INSIGHTS

📌 Absence in gross dissection does not equal absence in anatomy.

📌 Cadaveric observation alone cannot define microscopic neural architecture.

📌 Many sensory systems are revealed only through histological and molecular methods.

🔴 🚀 TAKE HOME

✅ Sensory fibers cannot be identified with the naked eye.

✅ They form microscopic plexiform networks over highly innervated tissues.

✅ Modern microscopy-not gross dissection-is required to reveal them.

➡ Confusing “NOT SEEN” with “NOT EXISTING” risks replacing science with assumption.

450

Dr.Kartik Sonawane

@KartikBSonawane

5 months ago

🎯 The Neural Armor of Bone: Understanding Periosteal Innervation #RegionalAnesthesia #PainMedicine #Anatomy #Periosteum #BonePain #NerveAnatomy #PainScience #UltrasoundGuidedBlocks #TipOfTheDay #MyRATips Tip of the Day: 📌 Bone pain - Most intense nociceptive experiences. 📌 The Periosteum - Neural command center of skeletal pain, where dense sensory networks convert mechanical injury into powerful nociceptive signals. 🔴 🦴 A. BONE INNERVATION HIERARCHY 📌 Periosteum → Highest nerve density 📌 Bone marrow → Moderate innervation 📌 Cortical bone → Minimal neural presence 📌 Histological studies show dense sensory & sympathetic neural plexuses within the periosteum, explaining the severe pain produced by: ✔ Fractures ✔ Periosteal stripping ✔ Orthopedic drilling 🔵 🧠 B. NEURAL ARCHITECTURE (Periosteal Innervation) 1. Sensory Afferent System 📌 Major nociceptive fibers: ✔ A-delta fibers - Thinly myelinated, Fast conduction, Sharp, localized fracture pain. ✔ C fibers - Unmyelinated, Slow conduction, Deep aching bone pain 📌 Arise from Dorsal Root Ganglia and reach the periosteum along vascular and fascial pathways. 2. Sympathetic Innervation 📌 Periosteum also contains postganglionic sympathetic fibers from paravertebral ganglia. 📌 These fibers travel with periosteal vessels and regulate: ✔ Bone blood flow ✔ Bone remodeling ✔ Pain modulation 📌 Identified Neurochemical Markers: ✔ Vasoactive intestinal peptide (VIP) ✔ Neuropeptide Y ✔ Tyrosine hydroxylase-positive fibers 🟢 🌐 C. FOUR GATEWAYS 1. Muscular Attachments (Myoperiosteal Route) 📌 Nerves supplying muscles attached to bone send small periosteal branches at their insertions. 📌 Muscle contraction/spasm - amplifies bone pain via shared neural pathways. 2. Articular Nerves (Osteo-Articular Route) 📌 Nerves supplying adjacent joints extend branches to the periosteum. 📌 This explains bone pain associated with joint pathology. 3. Cutaneous Nerves (Dermato-Periosteal Route) 📌 Some periosteal branches originate from cutaneous nerves supplying the overlying skin. ✔ SCNs → clavicle ✔ IVNs → rib ✔ LFCN → iliac crest 📌 This explains bone tenderness on superficial palpation. 4. Nutrient Foramen (Endosteal Route) 📌 Nerves accompanying nutrient arteries enter bone via nutrient foramina Supplying, ✔ Bone marrow ✔ Endosteum ✔ Inner cortical bone 📌 However, periosteum remains the dominant pain generator. 🟣 ⚡D. CADAVERIC STUDIES LIMITATIONS 📌 Periosteal branches are extremely fine & delicate, often forming microscopic plexiform networks. 📌 Therefore, their absence in cadaveric dissection does not imply true anatomical absence. 📌 Factors making periosteal neural pathways difficult to demonstrate include, ✔ Post-mortem tissue changes ✔ Collapse of microvascular-neural bundles ✔ Difficulty identifying unmyelinated fibers ➡ Modern immunohistochemical & neurotracing techniques often reveal neural networks that are not visible in traditional dissection. 🟣 ⚡E. WHY SEVERE PERIOSTEAL PAIN? ✔ Extremely high nociceptor density ✔ Mechanical sensitivity of A-delta fibers ✔ Release of inflammatory mediators after injury ✔ Sensory–sympathetic interactions Together these create one of the most powerful nociceptive environments in the body. 🟠 🚀 TAKE HOME 📌 Periosteum acts as the neural interface of the skeleton & is the primary source of fracture pain. 📌 Bone marrow manipulation alone produces far less pain than periosteal injury. 📌 Dense networks of A-delta and C-fiber nociceptors dominate bone pain signaling. 📌 Periosteal nerves has 4 anatomical gateways: ✔ Muscular attachments ✔ Articular nerves ✔ Cutaneous nerves ✔ Nutrient foramina 📌 Understanding these pathways helps predict which neural networks must be targeted for effective skeletal analgesia.

$KartikBSonawane's tweet photo. 🎯 The Neural Armor of Bone: Understanding Periosteal Innervation #RegionalAnesthesia #PainMedicine #Anatomy #Periosteum #BonePain #NerveAnatomy #PainScience #UltrasoundGuidedBlocks #TipOfTheDay #MyRATips Tip of the Day: 📌 Bone pain - Most intense nociceptive experiences. 📌 The Periosteum - Neural command center of skeletal pain, where dense sensory networks convert mechanical injury into powerful nociceptive signals. 🔴 🦴 A. BONE INNERVATION HIERARCHY 📌 Periosteum → Highest nerve density 📌 Bone marrow → Moderate innervation 📌 Cortical bone → Minimal neural presence 📌 Histological studies show dense sensory & sympathetic neural plexuses within the periosteum, explaining the severe pain produced by: ✔ Fractures ✔ Periosteal stripping ✔ Orthopedic drilling 🔵 🧠 B. NEURAL ARCHITECTURE (Periosteal Innervation) 1. Sensory Afferent System 📌 Major nociceptive fibers: ✔ A-delta fibers - Thinly myelinated, Fast conduction, Sharp, localized fracture pain. ✔ C fibers - Unmyelinated, Slow conduction, Deep aching bone pain 📌 Arise from Dorsal Root Ganglia and reach the periosteum along vascular and fascial pathways. 2. Sympathetic Innervation 📌 Periosteum also contains postganglionic sympathetic fibers from paravertebral ganglia. 📌 These fibers travel with periosteal vessels and regulate: ✔ Bone blood flow ✔ Bone remodeling ✔ Pain modulation 📌 Identified Neurochemical Markers: ✔ Vasoactive intestinal peptide (VIP) ✔ Neuropeptide Y ✔ Tyrosine hydroxylase-positive fibers 🟢 🌐 C. FOUR GATEWAYS 1. Muscular Attachments (Myoperiosteal Route) 📌 Nerves supplying muscles attached to bone send small periosteal branches at their insertions. 📌 Muscle contraction/spasm - amplifies bone pain via shared neural pathways. 2. Articular Nerves (Osteo-Articular Route) 📌 Nerves supplying adjacent joints extend branches to the periosteum. 📌 This explains bone pain associated with joint pathology. 3. Cutaneous Nerves (Dermato-Periosteal Route) 📌 Some periosteal branches originate from cutaneous nerves supplying the overlying skin. ✔ SCNs → clavicle ✔ IVNs → rib ✔ LFCN → iliac crest 📌 This explains bone tenderness on superficial palpation. 4. Nutrient Foramen (Endosteal Route) 📌 Nerves accompanying nutrient arteries enter bone via nutrient foramina Supplying, ✔ Bone marrow ✔ Endosteum ✔ Inner cortical bone 📌 However, periosteum remains the dominant pain generator. 🟣 ⚡D. CADAVERIC STUDIES LIMITATIONS 📌 Periosteal branches are extremely fine & delicate, often forming microscopic plexiform networks. 📌 Therefore, their absence in cadaveric dissection does not imply true anatomical absence. 📌 Factors making periosteal neural pathways difficult to demonstrate include, ✔ Post-mortem tissue changes ✔ Collapse of microvascular-neural bundles ✔ Difficulty identifying unmyelinated fibers ➡ Modern immunohistochemical & neurotracing techniques often reveal neural networks that are not visible in traditional dissection. 🟣 ⚡E. WHY SEVERE PERIOSTEAL PAIN? ✔ Extremely high nociceptor density ✔ Mechanical sensitivity of A-delta fibers ✔ Release of inflammatory mediators after injury ✔ Sensory–sympathetic interactions Together these create one of the most powerful nociceptive environments in the body. 🟠 🚀 TAKE HOME 📌 Periosteum acts as the neural interface of the skeleton & is the primary source of fracture pain. 📌 Bone marrow manipulation alone produces far less pain than periosteal injury. 📌 Dense networks of A-delta and C-fiber nociceptors dominate bone pain signaling. 📌 Periosteal nerves has 4 anatomical gateways: ✔ Muscular attachments ✔ Articular nerves ✔ Cutaneous nerves ✔ Nutrient foramina 📌 Understanding these pathways helps predict which neural networks must be targeted for effective skeletal analgesia.$

568

Tonix Pharmaceuticals @TonixPharma

5 months ago

We look forward to @AmerAcadPainMed’s #PainConnect2026! Our poster highlights clinically meaningful improvements in patient-centered outcomes in fibromyalgia with our FDA approved treatment. Learn more: https://t.co/GQ7FjzssP7 #Fibromyalgia #ChronicPain #PainScience #Tonix

MSKPhysioJournal

@MSKPhysioJnl

5 months ago

💡#Masterclass - 🟢 Open Access - https://t.co/eGlodTvGPX - check out our NEW masterclass on the Neuro-immune contributors to persistent musculoskeletal pain: from mechanisms to clinical assessment and management #Neuroinflammation #MusculoskeletalHealth #PainScience #ClinicalReasoning

MSKPhysioJnl's tweet photo. 💡#Masterclass - 🟢 Open Access - https://t.co/eGlodTvGPX - check out our NEW masterclass on the Neuro-immune contributors to persistent musculoskeletal pain: from mechanisms to clinical assessment and management #Neuroinflammation #MusculoskeletalHealth #PainScience #ClinicalReasoning

MSKPhysioJournal

@MSKPhysioJnl

5 months ago

📕 #Neuroimmune Special Issue Series - 🟢 OPEN ACCESS - https://t.co/zgF9aD3qYA - Could improving sleep and psychological wellbeing be a powerful way to break the cycle of inflammation and persistent musculoskeletal pain? #SleepHealth #PainScience #NeuroImmunology #MSKCare

MSKPhysioJnl's tweet photo. 📕 #Neuroimmune Special Issue Series - 🟢 OPEN ACCESS - https://t.co/zgF9aD3qYA - Could improving sleep and psychological wellbeing be a powerful way to break the cycle of inflammation and persistent musculoskeletal pain? #SleepHealth #PainScience #NeuroImmunology #MSKCare https://t.co/d8T3tXOYrO

MSKPhysioJournal

@MSKPhysioJnl

5 months ago

📕 #Neuroimmune Special Issue Series - https://t.co/80mpKVdrbf - Could neuroinflammation be the missing link transforming how we understand and treat persistent musculoskeletal pain? #Neuroinflammation #NeuroImmunology #MusculoskeletalHealth #PainScience

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