#PIEZO2 - Twitter Hashtag

about 1 month ago

📰Un estudio del @painchannels (@NeuroAlc) identifica un mecanismo clave del dolor crónico causado por lesiones nerviosas Demuestra que #Piezo2 desempeña un rol esencial en la hipersensibilidad mecánica en un modelo de neuropatía periférica en ratones https://t.co/NmCDY5vq16

SENC_'s tweet photo. 📰Un estudio del @painchannels (@NeuroAlc) identifica un mecanismo clave del dolor crónico causado por lesiones nerviosas

Demuestra que #Piezo2 desempeña un rol esencial en la hipersensibilidad mecánica en un modelo de neuropatía periférica en ratones

https://t.co/NmCDY5vq16 https://t.co/OSuj3fftFQ

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NYU Pain Research Center @NYUPainResearch

about 1 year ago

Mechanically evoked neuronal activity via Piezo2 and Nav channels is essential for the development and structural maturation of mechanosensory end-organs underlying gentle touch. #Mechanotransduction #Piezo2 https://t.co/jfCc0xIzis

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NYU Pain Research Center @NYUPainResearch

about 1 year ago

🧠💩 Pain in the Gut: Fusobacterium varium bacteria triggers IBS symptoms by hijacking Piezo2 signaling #GutMicrobiome #Piezo2 #VisceralHypersensitivity #Neurogastroenterology https://t.co/4uhC9Z7L6k

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Share4Rare_eng @Share4Rare_eng

over 1 year ago

#RecommendedReading 🗞️ Researchers have shown that mutations in the gene coding for the #PIEZO2 protein increase the sensitivity of pain receptors in mice 🐁 This suggests that PIEZO2 channels could serve as new drug targets for pain treatment 💥 👉 https://t.co/7h0LOF9CSe

Share4Rare_eng's tweet photo. #RecommendedReading 🗞️ Researchers have shown that mutations in the gene coding for the #PIEZO2 protein increase the sensitivity of pain receptors in mice 🐁

This suggests that PIEZO2 channels could serve as new drug targets for pain treatment 💥

👉 https://t.co/7h0LOF9CSe https://t.co/GYCFTU6kvd

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NYU Pain Research Center @NYUPainResearch

over 1 year ago

A novel mechanism behind episodic neuropathic pain—the interaction between dynamic blood vessel movements and Piezo2 mechanoreceptors in sensory neurons #piezo2 #neuropathicpain #nociceptors #tbertalab https://t.co/W8Da2gBRYm

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Jose Carlos Rivas Ferreira @jcrivasferr

over 1 year ago

The versatility in biological processes and the #disparity in the #expression of #PIEZO1 and #PIEZO2 between #cardiovascular and #neuronal #cells are the major problems that hinder its potential as a #therapeutic #target!! @HaoYin20 @ChrStaehr #channels https://t.co/qoTJLzbx7g

jcrivasferr's tweet photo. The versatility in biological processes and the #disparity in the #expression of #PIEZO1 and #PIEZO2 between #cardiovascular and #neuronal #cells are the major problems that hinder its potential as a #therapeutic #target!! @HaoYin20 @ChrStaehr #channels
https://t.co/qoTJLzbx7g https://t.co/nTMuYZhvSI

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Felix Viana @neuroviana

almost 2 years ago

Sanchez-Carranza @GaryRLewin1 and collegues report in @Brain1878 that #Piezo2 voltage-block regulates mechanical pain sensitivity https://t.co/pf2ELbSH3P With @anagomisg and J Fernandez Trillo @NeuroAlc I wrote a commentary on this provocative finding https://t.co/10RcrTLHkr

neuroviana's tweet photo. Sanchez-Carranza @GaryRLewin1 and collegues report in @Brain1878 that #Piezo2 voltage-block regulates mechanical pain sensitivity
https://t.co/pf2ELbSH3P
With @anagomisg and J Fernandez Trillo @NeuroAlc I wrote a commentary on this provocative finding
https://t.co/10RcrTLHkr https://t.co/cyWqS8zu3I

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Ingrid Carvacho @i_carvacho

over 2 years ago

#piezo2 #lipid regulation

Tibor Rohacs @RohacsTibor

over 2 years ago

Postdoctoral position is available in my lab, to study lipid regulation of mechanically activated Piezo2 #ionchannels Please retweet, and see lab website for details: https://t.co/L9iWbi9v9X

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Xin Duan @xinduan

over 2 years ago

(3) We further identified the mechanosensitive channel #Piezo2 as an Nts-RGC-enriched, perivascularly localized protein. Deletion of Piezo2 from retinal neurons or Nts-RGCs, but not endothelial cells, resulted in the loss of RGC-vascular contacts (Thx @ardemp @ShangMa5 @ZhaozhuQ)

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Hao Yin

@HaoYin20

over 2 years ago

#Piezo2 as Pulmonary Microvascular #EndothelialCell Shear sensor Piezo2, Not #Piezo1, downregulated in 1⃣EC + Hypoxia/TGFβ2 2⃣4 animal🐭🐭🐭🐷 #PulmonaryHypertension models 3⃣Human iPAH🫁EC siRNA Piezo2->#EndMT Daphne Merkus lab @ajpheartcirc 2022 https://t.co/0Y7pvo0tL0

HaoYin20's tweet photo. #Piezo2 as Pulmonary Microvascular #EndothelialCell Shear sensor

Piezo2, Not #Piezo1, downregulated in
1⃣EC + Hypoxia/TGFβ2
2⃣4 animal🐭🐭🐭🐷 #PulmonaryHypertension models
3⃣Human iPAH🫁EC

siRNA Piezo2->#EndMT

Daphne Merkus lab @ajpheartcirc 2022
https://t.co/0Y7pvo0tL0 https://t.co/b4qrz4Y8ld

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Hao Yin

@HaoYin20

over 2 years ago

#PhosphoLipaseD #Mechanotransduction Selective inhibition of #Piezo2, not #Piezo1 in sensory neurons by (intracellular) #LysophosphatidicAcid #PhosphatidicAcid, PLD enzymatic product A direct binding effect? Optogenetic PLD FIPI (PLD inhibitor) Now, a role of PLD1/2 in endothelial shear sensing?😁 @MattGabrielleRU @RohacsTibor bioRxiv 2024 https://t.co/mdPVfl1Glp

HaoYin20's tweet photo. #PhosphoLipaseD #Mechanotransduction

Selective inhibition of #Piezo2, not #Piezo1 in sensory neurons by (intracellular) #LysophosphatidicAcid #PhosphatidicAcid, PLD enzymatic product

A direct binding effect?

Optogenetic PLD
FIPI (PLD inhibitor)

Now, a role of PLD1/2 in endothelial shear sensing?😁

@MattGabrielleRU @RohacsTibor bioRxiv 2024
https://t.co/mdPVfl1Glp

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silex知の文献サービス (Silex Press LLC.) @silex_transl

almost 3 years ago

「退屈な糊」#グリア細胞が今、#消化管でも興奮を巻き起こす。中心仮説は、��腸管細胞・免疫細胞・ #マイクロバイオーム間のコミュニケーションを差配」。新技法で細胞マッピング、#PIEZO2 等遺伝子解析が進む。 https://t.co/59ZNdrbyHm

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IASP

@IASPpain

almost 3 years ago

A new article featured in #PRF’s #PapersoftheWeek explores the potentiation of #PIEZO2 mechanically activated currents in sensory neurons mediates vincristine-induced mechanical hypersensitivity. https://t.co/FQQn9VD1qx

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Pain Research Forum @PainResForum

almost 3 years ago

A new article featured in #PRF’s #PapersoftheWeek explores the potentiation of #PIEZO2 mechanically activated currents in sensory neurons mediates vincristine-induced mechanical hypersensitivity. https://t.co/I0VjegwHbw

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silex知の文献サービス (Silex Press LLC.) @silex_transl

about 3 years ago

#哺乳類性行動に #会陰メカノ感覚と #振動覚受容体 #PIEZO2 が必須である、としたScienceNIH報告に注目。マウスから欠損症患者に至る重厚研究。a platform for exploring the sensory basis of sexual pleasure、と�� https://t.co/8Kma2XJ6CH

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Tali @talius

about 3 years ago

How #Sensory #Neurons Impact the #Gut A study used human clinical data & animal models to reveal that receptor #PIEZO2 controls GI transit by sensing food & slowing #gut #motility rate. These findings could lead to therapeutic applications for #IBD, #IBS https://t.co/Ks5PFn2Gur

talius's tweet photo. How #Sensory #Neurons Impact the #Gut

A study used human clinical data & animal models to reveal that receptor #PIEZO2 controls GI transit by sensing food & slowing #gut #motility rate. These findings could lead to therapeutic applications for #IBD, #IBS https://t.co/Ks5PFn2Gur https://t.co/frEMRtz0MN

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Rajan Singh

@Rajan___Singh

about 3 years ago

#ANMS2023🔥 Fascinating talk, as always! @Beyderlab 👏 ➡️#GutFeelings: Mechanosensing in GI tract ✅50-90% of #functionalGI patients have “Mechano-Pathologies” ✅Gut-innervating extrinsic #Piezo2+ #MechanosensitiveNeurons put #brakes on GI transit @ANMSociety @MayoClinicGIHep

Kristen Smith-Edwards @KristenSEdwards

about 3 years ago

⁦@BeyderLab⁩ sharing his “Gut Feeling” on the importance of mechanical forces to execute GI function and highlighting this reference from the OG’s-Bayliss and Starling-who laid down the “law of the intestine” ⁦@ANMSociety⁩ ⁦@ENSP_mayo⁩ #ANMS23

KristenSEdwards's tweet photo. ⁦@BeyderLab⁩ sharing his “Gut Feeling” on the importance of mechanical forces to execute GI function and highlighting this reference from the OG’s-Bayliss and Starling-who laid down the “law of the intestine” ⁦@ANMSociety⁩ ⁦@ENSP_mayo⁩ #ANMS23 https://t.co/vLQRdXiBEX

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BeyderLab @BeyderLab

about 3 years ago

Deeply grateful 🙏 for an amazing collaboration with @ardemp and @Alex_Chesler on #mechanosensing by #Piezo2 #ionchannels, on a study 🤔 in @CellCellPress that shows #GI mechanosensitive extrinsic #sensory #neurons putting the BRAKES on GI #motility https://t.co/ebB12jLyjN

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BeyderLab @BeyderLab

about 3 years ago · Minnesota

So interesting 🧐 the old school dye fm1-43 that finds its way into #Mechanosensitive #cells depends on #piezo2 activation

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Britya Ghosh @BRIITYA

about 3 years ago

So happy to have been a part of this project! We showed that styryl dye, FM1-43 specifically labels #PIEZO2 activity and gives a direct readout of tactile stimulation of hairy skin. 📰 @NeuroCellPress https://t.co/b0hj9sGm79 #Neuron #Mechanoreceptor @NeuralCell

BRIITYA's tweet photo. So happy to have been a part of this project!

We showed that styryl dye, FM1-43 specifically labels #PIEZO2 activity and gives a direct readout of tactile stimulation of hairy skin.

📰 @NeuroCellPress
https://t.co/b0hj9sGm79

#Neuron #Mechanoreceptor @NeuralCell https://t.co/lCizTBp6Ej

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