Top Tweets for #PRG4
Excited to share @LubrisBio’s full length recombinant human #PRG4 (#rhPRG4) / #lubricin drug product is released for an upcoming #dryeye clinical study in Australia. Packing and labelling is complete, and we’re ready for distribution upon ethics committee approval. Stay tuned!

Proud of the #PRG4 #lubricin manufacturing progress made working with @LubrisBio & @AvidBioservices the past 2+ years = a 500L GMP run. Eye drop bottles now filled as we push towards the clinic and 2 GRAMS (!) of #rhPRG4 leftover for future preclinical research the next 5+ years.

Excited to share a new collaborative study lead by Ali Tamayol’s @limb_lab in Advance Healthcare Materials: microneedles with dissolvable backing for the programmed delivery of #PRG4/#lubricin to treat wounds. #uconn #uconnhealth
https://t.co/23A1uXacks
#PRG4 #lubricin AlphaLISA from @RevvityLifeSci! We developed it with @LubrisBio #rhPRG4, showed PRG4 down in Sjogrens tears, now great to have a kit made/optimized by Revvity CustomTeams. LLOQ ~5ng/ml, only 5ul of sample. Great for serum, tears, saliva - and we’ll see what else!

Congrats to Dr. Nikhil Menon! Fantastic job presenting 5 years of work in #UConn BME PhD program on #lubricin #PRG4 & #dryeye. 4 papers published, basic and translational findings, with more to come. I am a very grateful and a very #ProudMentor. Defence days are the best days 😊

Congrats to Dr. Tanguay! Outstanding PhD defense this past week at #UConnHealth. #PRG4 and bone! Proud and grateful to be his mentor, and big things to come for him as a PostDoc at #Yale.

So excited and grateful for a new 3 year grant from #CDMRP/#DOD’s Vision Research Program! Fortunate to work with @AliTamayol and @h_sheardown on a “Multifunctional Bandage Lens and Bio-adhesive for the Treatment of Corneal Wounds”. #PRG4 #lubricin #GelMA

A few days late... but congratulations to (non Twitter) Anusi Sarkar on a fantastic PhD defense! I am a proud and grateful supervisor 😀. #PRG4 #lubricin #breastcancer ... so much more to come!

New lab paper! rhPRG4 down regulates TNFα-mediated inflammation in corneal epi cells. In particular the previously unexplored, in dry eye, ubiquitin like molecule FAT10 that plays an important role in NFκB activation. #PRG4 #lubricin #DryEye. @KshitizKz
https://t.co/IDsYd35p9V
5 years?! 5 years at UConn Health, hard to believe. Time flies when you are sciencing, not to mention a pandemic. Here is to 5 more years+. #PRG4

Excited to present our work on #PRG4 in collagen based biomaterials here @TermisEU2022. A big thank you to co-authors @eamonjsheehy @HodgkinsonTom @tanninschmidt @fjobrien, to @LubrisBio for PRG4, and to @AdmireMsca @TissueEngDublin and @ambercentre for funding and support.

Time for a rockstar and #MSCA postdoctoral fellow @AustynMatheson who delivers her talk on the delivery of PRG4 using scaffold-based system to improve the biolubrication of cartilage tissue @TermisEU2022 @TissueEngDublin

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