Top Tweets for #Pitolisant
How does #pitolisant (#WAKIX) affect #IdiopathicHypersomnia symptoms? Bruce Corser, MD, from Sleep Management Institute, breaks down the open-label phase 3 data in this Q&A from #SLEEP2025.
https://t.co/XsflPRHgcg
At #SLEEP2025, Bruce Corser, MD, shared phase 3 open-label data showing #pitolisant significantly improved daytime sleepiness in patients with #IdiopathicHypersomnia. Over 80% of participants were responders. https://t.co/XsflPRHgcg #SleepMedicine #WAKIX #IH
The obesity therapies in the pipeline include Oral #semaglutide , #Danuglipron (PF-06882961), #Survodutide (BI 456906), #Liraglutide, #Cagrilintide, #Orforglipron, #Setmelanotide,
#Carbetocin, #Pitolisant, #DCCR, and others.
In November 2023, the FDA approved @EliLillyandCo and Company's #ZEPBOUND (tirzepatide) injection, for the treatment of obesity that activates both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (#GLP1) hormone receptors.
In December 2023, @pfizer announced topline data from the Phase IIb clinical trial (NCT04707313) investigating its oral glucagon-like peptide-1 receptor agonist (GLP-1RA) candidate, #danuglipron (PF-06882961), in adults with obesity and without Type 2 diabetes. The study met its primary endpoint demonstrating statistically significant change in body weight from baseline.
I am confused why @AASMorg is not outraged that @HarmonyBio refuses to seek FDA approval for #pitolisant in #OSA when @bioprojet did this in EU and Aculys is pursuing in Japan. Do #OSA patients in the US not matter? Meanwhile, working hard to spin disappointing IH results.
Harmony Biosciences announced topline results from the INTUNE study in patients with #IdiopathicHypersomnia. INTUNE was a Phase 3 placebo-controlled, double-blind, randomized withdrawal study. https://t.co/mxhbN6CBJ0
.@HarmonyBio released topline results from the INTUNE study of #pitolisant for #IdiopathicHypersomnia (IH). Primary endpoint for excessive daytime sleepiness did not achieve statistical significance against placebo in the randomized withdrawal phase. https://t.co/A4NRDeneHu
🇨🇳 RareStone Group has announced that the Chinese National Medical Products Administration (NMPA) has approved #pitolisant (Wakix) for the treatment of excessive daytime sleepiness (#EDS) or #cataplexy in adult patients with #narcolepsy! Read the article: https://t.co/VU4pU9vsw2
@cstroeckw >> What supplement/medication helped you most?
> #Pitolisant—H3 antagonist—disinhibits histamine release
Caveat: requires careful management of downsides!
Some issues with this:
—Can exacerbate #MCAS
—Stimulates RAS (which can be presumed dysregulated with #LongCovid / #MECFS)
@ahandvanish > 15. Modafinil (esp for nerve, cognition, & POTS)
for disorders of cognition and wakefulness with dysautonomia:
+ Histamine H3 antagonists (eg. pitolisant)
+ Sigma-1 agonists (esp. donepezil, which is also an AChEI)
but do take care to prevent feedback loop exacerbating MCAS
@cstroeckw > What is the supplement/medication that you think helped you most? #MECFS #LongCovid
#Pitolisant. It’s an H3 antagonist & *disinhibits* #histamine release.
> You can name only one.
(Whew! I wouldn’t have the stamina to list all the things I take to manipulate my metabolism…)
@Alice_mecfs > how much (if at all) has treating #POTS improved your #MECFS symptoms?
If I don’t take Pitolisant (histamine H3 antagonist), I have *intolerable* orthostatic intolerance—can’t sit in front of a laptop because my brain starts frying the minute I even contemplate standing up. 😵💫
Looks like Australia dodged a bullet with #Pitolisant (#Wakix) > Check out this scathing, yet amazing in depth investigation into @HarmonyBio by @ScorpionFund https://t.co/5z07DZohTd #Narcolepsy
ピトリサント：ヒスタミンH3 受容体の働きを阻害して、脳内のヒスタミン量を増やす薬（ヒス タミンH3 受容体拮抗薬）。
アメリカ、ヨーロッパでは、過眠症の１つであるナルコレプシーの治療薬 として使われている。
#ピトリサント（ヒスタミンH3受容体拮抗薬/逆作動薬）
#Pitolisant
Via @TheLancetNeuro: Symptoms improved for children with narcolepsy symptoms after treatment with #pitolisant, but researchers say more studies are needed to confirm the drug’s long-term safety: https://t.co/33weeSwjyP
#neurotwitter #PediatricNeurology @AANMember
L'@EMA_News accorde une extension d'indication à l'AMM pour le médicament #pitolisant Wakix, chez l'enfant de plus de 6 ans. Maladie rare, la #narcolepsie résulte dans l’incapacité du cerveau à réguler le cycle veille/#sommeil normal.💤
Par @MedscapeFrance https://t.co/qWGZZw7pNz
Extension d'AMM européenne en pédiatrie pour le traitement de la narcolepsie #Wakix* #pitolisant
https://t.co/tPlLDuLpcA
@Doc_Valerie @Ultracaustique @ASlavitt I have also been wondering whether #pitolisant might be helpful in #LongCOVID, especially for those with symptoms of #MCAS and #hypersomnolence. It is an expensive new drug though, and of course not FDA-approved for long COVID. Would be good to see an RCT done.
#Pitolisant
Perdón soy un puberto.
🆕 #ApnéeduSommeil : un médicament 💊 autorisé pour lutter contre la #somnolence diurne excessive
Le #pitolisant (Ozawade, @bioprojet ) dispose d'une autorisation de mise sur le marché européen dans la somnolence #diurne excessive.
➡️https://t.co/OzEsk7ChYG
@Sciences_Avenir
Award winning poster 06/05/21 at Physician Investors Conference.
Pitolisant efficacy in Narcolpesy: A Systematic Review.
#poster #awardwinning #narcolepsy #pitolisant
The drug, marketed as Wakix, was previously approved for the treatment of excessive daytime sleepiness in adults with narcolepsy.
More on the FDA approval of #pitolisant:
https://t.co/xvMbP1Odog
Come see me tomorrow #WorldSleep2019 in 12:30-2:00pm, room 118-120. Thorpy and I will conclude the presentation with a guided nap for all weary participants. @HarmonyBiosci #narcolepsy #Wakix #pitolisant
The #FDA has approved #WAKIX (#pitolisant) to treat #excessivedaytimesleepiness (#EDS) in adult patients with #narcolepsy.
https://t.co/eb3L8Rt5Q8
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