Top Tweets for #Pomc
Hypothalamic obesity is a disease of #melanocortin signaling: pharmacologic #MC4R activation with #setmelanotide mimics endogenous α MSH, counters #AgRP-driven hunger signaling in the #POMC ARC→PVN pathway, and restore energy homeostasis in selected patients.
https://t.co/azz2mbD8jO
💢Beyond satiety: unraveling the complex roles of POMC neurons in behavior and metabolism
📌 Las neuronas #POMC hipotalámicas se consideran clásicamente mediadoras de la saciedad, que actúan en respuesta a señales metabólicas y hormonales y en oposición a las neuronas de la proteína relacionada con Agouti (AgRP) para mantener el equilibrio energético
https://t.co/RLYds5c6wr
@ObesitySeen
Hormones and neural signals converge on the brain to regulate energy balance. The hypothalamic melanocortin circuit, powered by hunger #AgRP & satiety #POMC neurons, responds to GLP-1 & #leptin. Gut hormones & vagal nerve pathways relay real-time info about food intake to fine-tune appetite and energy use, helping maintain long-term energy homeostasis.
https://t.co/YFrjbppuPE
Our latest study @SciImmunology on perception of #hunger and #immunity. #BrainBody #Melanocortins #AgRP #POMC neurons. #Brain-#liver axis. Permissive action of #stress #hormones.
Led by @Albuquerquejp85
Scientists have shown that activating neurons that promote hunger or satiety can mimic the #immunoregulatory effects of #fasting or feeding in mice, respectively. @OfficialUoM @GiuseppeDAgos12
Learn more in Science #Immunology: https://t.co/1auUblWzCf
Melanocortins are a family of related #peptides comprising α-MSH, γ-MSH, and ACTH that all derive from the precursor protein proopiomelanocortin (#POMC).
As pioneers in #melanocortins, CLINUVEL’s research focuses on how this powerful family of hormones and their analogues may be translated into therapies for patients in need.
Learn more here: https://t.co/8eeZrL03HZ
#vitiligo #CNS #raredisease #afamelanotide
When you started being in Crypto to be financially stable but now you're mentally unstable too...
#cryptocurrency #crypto #meme #POMC #Fixrate
🥰 We witness the transformative power of the POMS project, not only enriching the lives of our beloved pets but also fostering a sense of unity and compassion among their devoted guardians.
$POMC
#poms #pomc #alopeciax #pomeranian #Pomerz
🤪Leading the Way in Canine Innovation
Contribute to the POMS project, where your support drives meaningful research for Pomeranian health and happiness.
$POMC
#poms #pomc #alopeciax #pomeranian #Pomerz
Dream Big, Leap Forward in 2025!
Happy New Year, POMS family!
May 2025 bring you and your poms companions endless joy, health, and love.
Here's to cherishing every wag and cuddle together!
$POMC
#poms #pomc #alopeciax #pomeranian #Pomerz #newyear
Top citations 2024: #13🏆✨
Jens Brüning (@MPI_Metabolism) and co-authors describe how reciprocal activity of #AgRP and #POMC neurons regulates #feeding and #metabolism.🧠🍽️
https://t.co/gscZFlDaxB
🚨 He is back again! 🚨
🌐POMS Website (https://t.co/jC6BZuFrWx)
♾️POMS_Official Channel (https://t.co/TSWpTsoT8L)
📌Pomerz Start Go Link (https://t.co/d8QPQIZ7Ud)
📌Pomerz Community Go Link (https://t.co/nntarvEnEQ)
$POMC
#poms #pomc #alopeciax #pomeranian
Looking at the owner smiling happily
We have a duty to make the dog happy
$POMC
#poms #pomc #alopeciax #pomeranian #Pomerz
WHY POMS?
Pomeranians are cute and lovely family and friends to people.
The cute and lovely appearance on the outside is what people see only on the outside, but Pomeranian actually suffer from a lot of diseases themselves.
$POMC
#poms #pomc #alopeciax #pomeranian #Pomerz
Regulation of leptin signaling and diet-induced #obesity by SEL1L-HRD1 ER-associated degradation in #POMC expressing neurons @NatureComms https://t.co/T8qEZpNiMG
The POMS project aims to understand and surpass dermatological conditions afflicting Pomeranians and double-coated breeds, particularly alopecia X.
🌐POMS Website (https://t.co/iKBrjAmyBj)
♾POMS_Official Channel (https://t.co/Nprnsn0Mbx)
$POMC
#poms #pomc #alopeciax #pomeranian
Wishing you a joyful start to the week!
May you and your Pomeranian have a happy and wonderful week together!
🌐POMS Website (https://t.co/jC6BZuFrWx)
♾POMS_Official Channel (https://t.co/TSWpTsoT8L)
$POMC
#poms #pomc #alopeciax #pomeranian
This reciprocal relationship forms a symbiotic bond where both parties thrive together, exemplifying the harmonious coexistence between humans and dogs.
🌐POMS Website (https://t.co/iKBrjAmyBj)
♾POMS_Official Channel (https://t.co/Nprnsn0Mbx)
$POMC
#poms #pomc #alopeciax #pomeranian
#ARTxSCIENCE 2024:
Discover the power of science combined with artistic expression and learn about the potential of stem cell research to transform the lives of people.
Help up find a winner of the best fusion of ARTxSCIENCE on https://t.co/HOjbeIgTm7
‘Hungry for more – appetite regulation in the #brain’
Whether we are starving or feel full is a state controlled by our brain, more precisely the hypothalamus. This small region in the center of our brain contains #neurons that release signals telling us whether we are hungry or satiated. Our goal is to establish a #humanbrainmodel of appetite regulation to provide a platform for metabolism and obesity research.
#Obesity affects 1 in 8 people worldwide and is connected to devastating comorbidities like #cancer or #cardiovasculardiseases. Increasing evidence suggests that the cause is less excessive food intake but rather a dysregulation of energy homeostasis in the brain. A human model of these neural networks can shed light on appetite regulation and help develop and understand weight-lowering medication such as Wegovy.
Our group has developed a protocol to generate key #hypothalamicneurons such as the hunger neurons AGRP and satiety-promoting POMC neurons. This stem cell-derived model allows us to both unravel their embryonic development in human and perform functional studies by treating the neurons with hormones and obesity drugs to record their functional response.
This image shows #humanneurons releasing the satiety hormone aMSH (in red) to suppress appetite. The process of directing stem cells towards the fate of hypothalamic neurons takes 50 days. Then, the cells reach a maturity level where they fire action potentials and release hormones so we can investigate their role in energy homeostasis.
@UCPH_Research @MCRI_for_kids @GlobalLumc @LUMC_Leiden @novonordiskfond
Submission by Anika Mueller, PhD fellow
Agnete Kirkeby Lab, reNEW Copenhagen, Denmark
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