Anika K Mueller

PhD student in Agnete @Kirkeby_lab at @reNEW_Global //
Currently tracing lineages in human hypothalamic neurons

[Anika K Mueller @anikakmueller]

Thrilled to share our new preprint on @biorxiv_neursci about generating human arcuate nucleus neurons from stem cells! This is our first paper of #teamhypothalamus in the @Kirkeby_Lab 🧠 in collab with @tunepers lab.
Check out here👇
https://t.co/gG8wIL3txg
#HypoGRC #stemcells

[Student Committee in Neurometabolism @SCiNeurometab]

📢Join us this Thursday, July 10th at 11:00 AM EST for another Neurometabolic Seminar! 🧠

This week, we welcome @AnaDomingosLab, renowned for her work on the neurobiology of obesity. She will present: “Sympathetic circuitry in Obesity” 👨‍🏫

Register here! https://t.co/IrOwg0MNQK

[Anika K Mueller @anikakmueller]

@celarber @WrayLabUCL @AlzSocResearch Nice study, congratulations to you and the team!

[StemCell Summer School @HydraSchool]

The delegates and faculty of #SCSS2024. The first three days have been intense, stimulating, and a lot of fun. Lots still to look forward to!

[preLights @preLights]

Many thanks to @nathalie_krauth for compiling a list capturing the #preprints discussed at the 2024 Hypothalamus GRC meeting!

Topics: neural circuits, molecular mechanisms + the role of the hypothalamus in health & disease.

Check out the #preList ⬇️ 👀
https://t.co/18wxmij27m

[Anika K Mueller @anikakmueller]

@nathalie_krauth Congratulations 🎉

[Anika K Mueller @anikakmueller]

Please vote for my pretty neural spheroid full of #POMC!
#scicomm #stemcell

[reNEW @reNEW_Global]

#ARTxSCIENCE 2024:
Discover the power of science combined with artistic expression and learn about the potential of stem cell research to transform the lives of people.

Help up find a winner of the best fusion of ARTxSCIENCE on https://t.co/HOjbeIgTm7

‘Hungry for more – appetite regulation in the #brain’

Whether we are starving or feel full is a state controlled by our brain, more precisely the hypothalamus. This small region in the center of our brain contains #neurons that release signals telling us whether we are hungry or satiated. Our goal is to establish a #humanbrainmodel of appetite regulation to provide a platform for metabolism and obesity research.

#Obesity affects 1 in 8 people worldwide and is connected to devastating comorbidities like #cancer or #cardiovasculardiseases. Increasing evidence suggests that the cause is less excessive food intake but rather a dysregulation of energy homeostasis in the brain. A human model of these neural networks can shed light on appetite regulation and help develop and understand weight-lowering medication such as Wegovy.

Our group has developed a protocol to generate key #hypothalamicneurons such as the hunger neurons AGRP and satiety-promoting POMC neurons. This stem cell-derived model allows us to both unravel their embryonic development in human and perform functional studies by treating the neurons with hormones and obesity drugs to record their functional response.

This image shows #humanneurons releasing the satiety hormone aMSH (in red) to suppress appetite. The process of directing stem cells towards the fate of hypothalamic neurons takes 50 days. Then, the cells reach a maturity level where they fire action potentials and release hormones so we can investigate their role in energy homeostasis.

@UCPH_Research @MCRI_for_kids @GlobalLumc @LUMC_Leiden @novonordiskfond

Submission by Anika Mueller, PhD fellow
Agnete Kirkeby Lab, reNEW Copenhagen, Denmark

[Hypothalamus Gordon Research Conference 2024 @HypothalamusGrc]

Check out this amazing community! 🤩 A heartfelt thanks to all of you for making this such a special meeting! See you in 2026!! #HypoGRC

[The Williams Lab @thewilliamslab]

And so it begins...

[The Williams Lab @thewilliamslab]

#HypoGRC brewery your shuttle to
@BrewSideByEach

[reNEW @reNEW_Global]

New preprint out from the @Kirkeby_Lab on generation of appetite-regulating neurons from #stem cells. These neurons are thought to be key targets of #Leptin as well as #GLP1 drugs (#Wegovy, #Zepbound), and can function as a model to study drug functions. https://t.co/HX9G1RDEOO

[Anika K Mueller @anikakmueller]

@MLAgerholm_ @biorxiv_neursci @Kirkeby_Lab @tunepers Thank you!!

[Anika K Mueller @anikakmueller]

Thrilled to share our new preprint on @biorxiv_neursci about generating human arcuate nucleus neurons from stem cells! This is our first paper of #teamhypothalamus in the @Kirkeby_Lab 🧠 in collab with @tunepers lab.
Check out here👇
https://t.co/gG8wIL3txg
#HypoGRC #stemcells

[Anika K Mueller @anikakmueller]

@celarber @biorxiv_neursci @Kirkeby_Lab @tunepers Thanks a lot Charlie!!

[bioRxiv Neuroscience @biorxiv_neursci]

Generation of human appetite-regulating neurons and tanycytes from stem cells https://t.co/kx1UKGToXJ #biorxiv_neursci

[Anika K Mueller @anikakmueller]

@cancer_curious Thanks a lot, I hope you'll enjoy the read! 🥰

[Science Magazine @ScienceMagazine]

The #hypothalamus plays a large role in coordinating the array of neuronal signals that are responsible for keeping the body in a stable state.

A special issue of Science unpacks this key brain region’s impact on physiological and behavioral homeostasis. https://t.co/TRJltFWmTF

[Lennart V. Schneider @lennberto]

Our new preprint about an organoid model of heart and brain interaction is now availabe! Excited to share my PhD work in the group of @MariaPatapia. Thank's to all collaborators from @pharmaumg and @lab_fischer.
👇👇👇
https://t.co/qlPYBxuFkY

[Madeleine Linneberg-Agerholm @MLAgerholm_]

Thank you @ScienceCluster @novonordiskfond and all of the organisers for an amazing #stemcellniche2023 that exceeded all expectations - now back to reality! 🥲

[Pint of Science DK @pintofscienceDK]

📣 #pint23 for the first time in #Copenhagen 🍻🧑‍🔬🇩🇰from 🔔TODAY!

🗓22-24 May, at 19.30
📍3 venues
🧑‍🔬️18 speakers

Don't know which event to attend?! 🤨
⬇️⬇️Look at the entire program below ⬇️⬇️

➡️Follow us at https://t.co/wuVypdT1Ar
🎟Ticket for FREE https://t.co/Nuh5ToFYGT

[Anika K Mueller @anikakmueller]

Come by on Monday 24th to have a drink and hear my colleague chat about what we do in the #lab everyday making neurons in a dish 🧫 🙌
@pintofscienceDK #scicomm #pint23
#beautifulmind

[Pint of Science DK @pintofscienceDK]

📣 #pint23 in #Copenhagen #beautifulmind 🧠

Join us with @AlrikSchorling from @reNEW_Global, who will talk about a new potential treatment for Parkinson’s disease using cells 🧫💉

🗓 Wednesday, May 24th, 19.30
📍 Dispensary (Nørrebrogade 184)
➡️ Info https://t.co/o6t4wY1OZC