Top Tweets for #ProstateJC

almost 5 years ago

@PCF_Science BRCA2 patients clearly at higher risk of aggressive prostate cancer. BRCA1 likely also at increased risk of prostate cancer. Best evidence comes from IMPACT trial. #prostatejc

wandering_gu's tweet photo. @PCF_Science BRCA2 patients clearly at higher risk of aggressive prostate cancer. BRCA1 likely also at increased risk of prostate cancer. Best evidence comes from IMPACT trial. #prostatejc https://t.co/ph9nHe76JR

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almost 5 years ago · Scotts Valley

@PCF_Science An important research direction is to examine patient reported outcomes with germline testing. Please refer patients who have undergone genetic testing for #prostatecancer to join the PROGRESS registry #prostatejc @vedangiri https://t.co/brfohlRSKQ

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almost 5 years ago

@PCF_Science ⬆️ risk of clinically significant #prostatecancer and younger age at diagnosis in BRCA2 carriers ➡️ consider lower PSA threshold for further diagnostic workup (eg, markers, MRI, biopsy). Nice paper by @heatherhcheng et al #prostatejc

LoebStacy's tweet photo. @PCF_Science ⬆️ risk of clinically significant #prostatecancer and younger age at diagnosis in BRCA2 carriers ➡️ consider lower PSA threshold for further diagnostic workup (eg, markers, MRI, biopsy). Nice paper by @heatherhcheng et al #prostatejc https://t.co/jlJApzPxTH

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almost 5 years ago

@PCF_Science 1⃣ An increasing number of men, often through cascade testing, are being diagnosed with pathogenic germline variants with an increased risk for prostate cancer. Coordination from providers across specialties will be key to helping them understand their risk. #ProstateJC

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almost 5 years ago

#prostatejc

almost 5 years ago

@PCF_Science Thanks for selecting this article! Recommendations from NCCN and Philly Consensus meeting suggest starting at age 40, potentially tighter (e.g. annual) screening intervals depending on PSA levels.

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almost 5 years ago

@Ecastromarcos @SessineMichael We are generally not, largely due to lack of insurance coverage with non-elevated PSA. However, working with @NCIBillDahut @Dr_RaviMadan @heatherhcheng & team, with protocol currently open at @theNCI that covers MRI (as well as travel costs): https://t.co/UuMh12ReaA #prostatejc

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almost 5 years ago

Q2: What is the current state of the evidence on #ProstateCancer screening for patients with #BRCA2 and other pathogenic variants? #ProstateJC

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almost 5 years ago

#prostatejc

almost 5 years ago

Patients had pathogenic germline variants in BRCA1, BRCA2, DNA mismatch repair genes (Lynch Syndrome), and CHECK2, among others. A total of 12/45 patients (26.7%) underwent biopsy. Of the 12, there were three with GG1 prostate cancer, one with GG2 prostate cancer.

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almost 5 years ago

There are many unanswered questions when it comes to prostate cancer screening strategies in these men (and avoiding over-screening). While our clinic highlights one strategy, the NCI (NCT03805919) highlights another. What other strategies have you seen/used? #ProstateJC #PCF

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almost 5 years ago

@PCF_Science @wandering_gu @samsimsal @smkaff @randy_vincejr @tudor_borza @sofiamerajver @Caba_L @PCFnews @LoebStacy @soulehoward1 @AndreaMiyahira @UMichUrology @UMRogelCancer Thanks for sharing! Here is a brief summary of some highlights of the article. Looking forward to discussing! #ProstateJC #PCF

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almost 5 years ago

@PCF_Science As part of research protocol, we have started at younger age (35) and used lower PSA thresholds, and urine biomarker. #prostatejc

wandering_gu's tweet photo. @PCF_Science As part of research protocol, we have started at younger age (35) and used lower PSA thresholds, and urine biomarker. #prostatejc https://t.co/clVckQqto2

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almost 5 years ago

Poll for medical oncologists: what is your practice regarding germline genetic testing for #prostatecancer? #prostatejc

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almost 5 years ago

Poll for urologists: what is your practice regarding germline genetic testing for #prostatecancer? #prostatejc

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almost 5 years ago

What are the main barriers to genetic evaluation in your clinical practice? #ProstateJC

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almost 5 years ago

@PCF_Science Barriers to germline testing for #prostatecancer at multiple levels: variable interest among patients, differing views on genetic guidelines, variable availability of genetic counseling & ease coordinating care, concerns about legal & financial implications of testing #prostatejc

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almost 5 years ago

@PCF_Science Germline genetic evaluation is important for #prostatecancer management (e.g., PARP inhibitors) & clinical trial eligibility, as well as personalized cancer risk accessment & screening recs for patients and their family members- concerning that it is underutilized #prostatejc

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almost 5 years ago

Why is germline genetic evaluation important in #ProstateCancer? #ProstateJC

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