Top Tweets for #RaFJC
𝗗𝗮𝘆 𝟮 𝗼𝗳 #RaFJC 💚
Implantation requires delicate immune balance. Enough inflammation to remodel the uterus, but enough tolerance to accept the embryo. Cytokines, NK cells, and macrophages shape embryo acceptance.
#RaFJC #Implantation #Fertility #immuneresponse
🥳See you in the next #RaFJC!
Follow @Repro_Fertility to find out what's coming!
Thanks @norahspears @horne_research @schweizer_nina
🎉 That’s a wrap on this #RaFJC journal club!
Huge thanks to everyone who read, shared, voted, and engaged in debate.
📌 Missed something? Catch up via #RaFJC
🔜 Stay tuned for our next journal club - coming soon!
#Microbiome #Piglet
These changes highlight the dynamic and sensitive nature of the #neonatal gut during the first days of life, a critical window for intervention and support.
#RaFJC #microbiome
@Repro_Fertility @norahspears @horne_research @dallas_soffa @schweizer_nina
The #Piglet #Microbiome shifts drastically by day 3:
🔺Proteobacteria dominate
🔻Beneficial genera like #Lactobacillus & Ruminococcus drop
🔺Escherichia spikes (38%)
🦠 Early instability is real and measurable.
#RaFJC
📊 See Figure 1 to see the relative abundance at each stage!
💬 What insight from today's #RaFJC are you taking into your work?
🟣 Drop your takeaways
🟢 Ask a question
🟡 Share your next steps
🔁 Let's keep this thread going!
#Microbiome #Piglet
🧠 The study opens up some exciting possibilities for enhancing #Piglet health!
Which of these strategies would you prioritise?👇
🔘 Modulate sow vaginal flora
🔘 Enrich colostrum with probiotics
🔘 Re-seed piglets after day 3
🔘 Improve crate hygiene
#RaFJC #Microbiome
Other suggestions?
🔁 D10 resembles D0
💪 Maternal imprinting is resilient
🧠 The idea of a "core microbiome" taking shape by day 10 is intriguing for intervention planning
The main conclusion?
Despite the chaos on D3, #Piglets' #Microbiomes "reset"
#RaFJC
🙌 This study challenges assumptions about early-life seeding
💥 Crate disinfection and clean environments? It had no significant impact on gut microbiota colonisation
🧪 It's not where they are born, but how and from whom
#RaFJC #Microbiome #Piglet
Key findings
🧬 The #Birthcanal #Microbiome –rich in #Lactobacillus– seeded the #Piglet gastrointestinal tract.
👍 Could be used as a mirror of human vaginal delivery
❌ Colostrum had little impact.
💡 Could interventions in the dam's vaginal flora boost offspring health?
#RaFJC
By weaning (day 21), the #Piglet #Microbiome is more predictable.
➡️ The day 10 profile explains almost 60% of the variation.
❌ Environmental factors (crate, colostrum) contribute little.
Microbial "memory" builds postnatally.
#RaFJC
📊 See the results in Table 5!
Despite the microbial chaos on day 3, the #Piglet #Microbiome begins stabilizing by day 10.
🔁 The day 0 microbiome still explains 15.6% of the variation at day 10
🌸 #BirthCanal still matters: 6.5% of the variation
#RaFJC
📊 See the results in Table 4!
Day 3 = #Microbiome mayhem.
🦠 Low diversity
🧬 Dominated by Escherichia & Clostridium
🩺 Markers of dysbiosis, but #Piglets weren’t sick
This window may be key for intervention or risk.
#RaFJC
📊 Check Figure 2 to see the relative abundance of genera
The #Piglet #Microbiome shifts drastically by day 3:
🔺Proteobacteria dominate
🔻Beneficial genera like #Lactobacillus & Ruminococcus drop
🔺Escherichia spikes (38%)
🦠 Early instability is real and measurable.
#RaFJC
📊 See Figure 1 to see the relative abundance at each stage!
By day 0 (before suckling), 51.6% of the #Piglet gut #Microbiome is explained by the #BirthCanal alone
👉 Environmental sources like the farrowing crate? Just 2.1%
Maternal influence > environment at birth
#RaFJC
📊 Check Table 2 to see the multiple regression analysis
📊 Pre-analysis:
👉Microbes <2% ⇒ grouped as ‘Other’
👉Dam rectum data excluded (r = 0.99 w/ crate)
📈 Analysis:
👉PROC GLM for group comparisons
👉PROC REG (stepwise) for age modeling
Significance: P ≤ 0.05; trend: 0.05–0.10
#Piglet #Microbiome #RaFJC
👩🔬 The study design:
🐷 5 gilts (Landrace × Yorkshire × Duroc).
🧪 Piglets sampled at D0 (pre-suckling), D3, D10, & ~D21 (weaning).
🐷 Maternal & environmental sources: rectum, #BirthCanal, crate, colostrum.
🧪 Repeated swabs from 5 piglets/litter.
#RaFJC #Microbiome #Piglet
What shapes a newborn piglet's gut #Microbiome: the #BirthCanal, the barn, or colostrum? 🐷🌱
The authors asked this in a carefully controlled livestock study.
Let's dive into the methodology to find out the key points of sampling.
#RaFJC #Piglet
🦠Gut microbiota influence growth, immunity, and long-term health.
Let's break down what the authors found, why it matters, and what it means for porcine health.
#RaFJC #Microbiome #BirthCanal
Whether you work with humans, #livestock, or microbes, this study offers valuable insight into how early-life microbial seeding works - and why it matters for development, disease risk, and performance.
Tag a colleague who should follow this and join the #RaFJC!
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