Top Tweets for #S1PR
A new Science #Immunology study finds that the alarmin IL-25 induces epigenetic changes in inflammatory group 2 innate lymphoid cells, promoting #S1PR expression and enabling their circulation during helminth infections in mice. https://t.co/kt6tjuzAo2 #ILC2s
Nice summary/graphic of treatments for #IBD including: #S1PR #JAK #IL17 #IL23 #TNFa drugs
After success of $ABVX in Ph 3 #UC, needs to be updated to add #Obefazimod which reduces the number of #Th17 cells/#IL17 produced by upregulating miR-124. New MOA
https://t.co/33EUTDXgw8
Overview of IBD biology and treatment mechanisms ⚙️🎯
📸: https://t.co/ZrIybx6ZXd
🌞Daily Article Sharing
✅Review: Lysophospholipid receptors in neurodegeneration and neuroprotection
🔗https://t.co/e6xT6SerwT
#Sphingosine-1-phosphate #S1P receptors #lysophosphatidic acid #LPAreceptors #Lpar #S1pr #fingolimod #FTY720
Sphingosine 1-phosphate receptor modulators in🔧treatment of "heavy" ⚙️ #IBD 💪
Good, long time experience of this kind of #SmallMolecules
in #MultipleSclerosis 🪛
💊 #S1PR future in advance therapy of #UC & #CD
Remember abt #SafetyUse & #contradictions to avoid sth like 👇🏼
Sands: S1PR modulators in #IBD : best positioned as a first line advanced therapy #GUILD @GuildConference @bruce_sands1
📰Latest updated entry on #Encyclopedia "#Sphingosine-1-Phosphate and Its Signaling Pathway Modulators" by @garinho29, @reneroblesce, Marc Puig Casadevall and @llramio
🔗Access link: https://t.co/zhZdLBYcpf
#Neurosciences #S1P #S1PR
Mark S. Freedman, MD (@MSDoc_Freedman) reviews the role of #S1PR modulators in #MS in this new CME activity! #Neurology #MedEd https://t.co/OTcjtTHvUW
Apply the latest clinical data on #S1PR modulators into individualized #MS treatment plans in this discussion featuring expert Mark S. Freedman, MD (@MSDoc_Freedman) #MultipleSclerosis #MedEd https://t.co/OTcjtTHvUW
Assess the benefits and risks associated with #S1PR modulators in managing #MultipleSclerosis based on the most recent clinical data. Featuring Mark S. Freedman, MD (@MSDoc_Freedman) #MedEd https://t.co/OTcjtTHvUW
Mark S. Freedman, MD (@MSDoc_Freedman) reviews the role of #S1PR modulators in #MS in this new CME activity! #Neurology #MedEd https://t.co/OTcjtTHvUW
'The sphingosine 1 phosphate/sphingosine 1 phosphate receptor axis: a unique therapeutic target in inflammatory bowel disease'
#IBD #S1PR #treatment
Read at https://t.co/RuvDaAM9D5
Awesome, rapid fire learning in this #MNIBDtweetorial by @IBD_Afzali on new and emerging therapies (think #JAKi and #S1PR agents) in #UC! 👇🏻💥💊@MondayNightIBD
@MondayNightIBD @DCharabaty @abbvie @pfizer 1/ Let’s start with a quick #IBDPoll 1⃣
⚡️What % of your pts w/ #UC fail to achieve adequate response w/ available Rx options❓
@MondayNightIBD @DCharabaty @abbvie @pfizer @BMC_series @NEJM @APandT @AGA_Gastro @ExpertOpinion 14/ #Tweetorial RECAP:
🔑30%-50% of pts w/ mod–sev #ulcerativecolitis have suboptimal Rx response
🔑JAK inhibition & #S1PR agonism have emerged as valuable Rx strategies
🔑Several candidates are poised to provide🆕options to address current unmet needs in #UC Rx
@MondayNightIBD @DCharabaty @abbvie @pfizer @BMC_series @NEJM @APandT @AGA_Gastro @ExpertOpinion 13/ 🔑#Etrasimod for mod-severe #UC
✅Selective #S1PR 1,4 & 5 modulator
🔺Ph2 trial: #etrasimod 2 mg improved Mayo clinical & endoscopic scores vs PBO 👇👇@AGA_Gastro
🔺 Mild AEs
🔺Ph3 trials underway
@MondayNightIBD @DCharabaty @abbvie @pfizer @BMC_series @NEJM @APandT @AGA_Gastro @ExpertOpinion 12/ 🔑 #ozanimod in moderate to severe #UC
✅Selective #S1PR 1&5 modulator
🔺Multicenter Ph3 #TrueNorth RCT
✅Efficacy & safety of #ozanimod in active UC w/ inadequate response to prior therapy 👇👇
@MondayNightIBD @DCharabaty @abbvie @pfizer @BMC_series @NEJM @APandT @AGA_Gastro 11/ 🔑#S1PR agonism
🔺 Novel strategy in the treatment of #UlcerativeColitis
🔺 PO meds
🔺Targets lymphocyte recirculation, through blockade of lymphocyte egress from the lymph nodes 👇👇
@ExpertOpinion
@MondayNightIBD @DCharabaty @abbvie @pfizer @BMC_series @NEJM @APandT @AGA_Gastro 10/ Let’s shift gears in our #IBD alphabet soup with #IBDPoll 3⃣
⚡️Sphingosine-1-phosphate receptor (#S1PR) agonist blocks🛑which of the following lymphocytic processes❓
The low down on sphingosine-1-phosphate lyase as a regulator of thymic egress
Read More: https://t.co/GY2dJU39iI
#Sphingosine1phosphatelyase #Thymicegress #Lymphocytes #Trafficking #S1PR #Dendriticcell #Autoimmunedisease #FTY720 #Fingolimod
IPMI Trend Show 2016
Tri Handoko presents "Mind Game"
#S1PR #ifdcouncil #IFDC #ipmidesigners… https://t.co/ipu1mBtjAI
IPMI Trend Show 2016
Tri Handoko presents "Mind Game"
#S1PR #ifdcouncil #IFDC #ipmidesigners… https://t.co/9060LVcv3B
IPMI Trend Show 2016
Tri Handoko presents "Mind Game"
#S1PR #ifdcouncil #IFDC #ipmidesigners… https://t.co/gXkOVxoIy8
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