Top Tweets for #SCIslets
https://t.co/VtsMi85h8C
Nice review. As described at the end, we actually tested #imeglimin, a novel diabetes drug available only in Japan now, and found that it enhances β-cell identity gene sets in #SCislets. Further optimization is needed, though.
https://t.co/CmR3sw3Ti4
Exciting research from @hazemibrahimi and @OtonkoskiL at @HelsinkiUniMed and @uppsalauni using isogenic stem-cell-derived islets in vitro and in vivo unravels the impact of heterozygous RFX6 variant on diabetes #DiabetesResearch #SCislets #BetaCells https://t.co/i4m3D0ApIL 🔓
Our recent review article describing
"Mitochondrial regulation in human pluripotent stem cells during reprogramming and β cell differentiation " is now out. Check it out here below 👇
#iPSCs #SCIslets #Diabetes #StemCells #CellTherapy
https://t.co/E5A12S1ARb
🚨Preprint alert🚨 I am thrilled to share our preprint describing full #suspension generation of #SCIslets in bioreactors.
Complete Suspension #Differentiation of Human #Pluripotent #Stem #Cells into Pancreatic #Islets Using Vertical-Wheel® #Bioreactors https://t.co/4B2fwgLDDt
We manufacture #SCIslets in full suspension protocol. Pictures from recent prep- (left) #islets stained with dye dithizone and (right) stained beautiful #islets in a tube (confirm presence of #insulin) #ShapiroLab #Diabetes @AlbertaDiabetes @UAlberta_FoMD @DRIF_Can @JDRF_Canada
Stem cell-derived islets hold great promise for the treatment of Type 1 diabetes, but there are still many challenges to be addressed. #SCislets #celltherapy #diabetes
Alternative transplantation sites to the liver have been proposed to minimize initial cell loss, but further strategies are needed to increase vascularization and nutrient transport. #transplantation #vascularization #SCislets #diabetes
Successful transplantation of stem cell-derived islets will need to address the stressors associated with hypoxia, nutrient deprivation, and inflammation immediately following the transplantation procedure. #transplantation #stressors #SCislets #diabetes
Strategies to prevent the immune response to transplanted stem cell-derived islets include engineering the cells to hide from the immune system and inducing local immune tolerance. #immunotolerance #immunoprotection #SCislets #diabetes
Encapsulation devices are used to protect transplanted stem cell-derived islets from the immune system, but there are issues with nutrient exchange and fibrosis around the implant. #immunoprotection #encapsulation #SCislets #diabetes
Improving the functionality of stem cell-derived beta cells is a key challenge for the widespread use of cell replacement therapy for T1D. #SCislets #celltherapy #diabetes
Recent clinical trials have shown glucose-responsive C-peptide production in T1D patients using stem cell-derived pancreatic endoderm cells and macroencapsulation devices. #PEC01 #PECDirect #SCislets #diabetes
#Type1diabetes is caused by the destruction of insulin-producing β cells, but stem cell-derived pancreatic tissue has the potential to provide a functional cure. #SCislets #celltherapy #diabetes
Glad the effect is now validated in #BetaCells. Something I do believe for a long time that culturing human #SCIslets in high glucose during terminal stages of differentiation result in lower secretion and mitochondrial respiration.
A glucose metabolite impairs insulin secretion in diabetes #diabetes #metabolism
@DPAGAthenaSwan @OxfordMedSci
https://t.co/VapBspm57k
Interesting findings in a new study by Tremmel and colleagues. #SCIslets #BetaCells #Isletgenomics
Validating expression of beta cell maturation-associated genes in human pancreas development https://t.co/ZFiycoRDdD
📣 Join us Monday, January 9, 12-1 pm MT
Dr. Dadheech @NidheeshDadhich (ADI Member Dr. James Shapiro's lab @UAlberta_FoMD) discusses pluripotent stem cell-islet therapy as a sweet solution to all forms of diabetes #T1D #T2D #SCIslets #BetaCellReplacement #DiabetesCellTherapy
Detailed protocol on how to differentiate functional pancreatic islets from stem cells https://t.co/4Nq2SD2IYA Great effort by @OtonkoskiL including @BioBarsby and many others @HelsinkiUniMed #stemcells #diabetes #scislets #pancreas
Our latest review article on opportunities and challenges for stem cell-derived islet therapy is now out. Highly excited to share our recent contribution. #iPSC #BetaCells #SCIslets #Diabetes https://t.co/mtFyFAzFIT
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