#SCTx - Twitter Hashtag

about 1 month ago

🧬 New IPO: Scribe Therapeutics (#SCTX) A new IPO is now available in the Fintch app. Scribe Therapeutics is an Alameda, California clinical-stage biotech founded in 2017, developing purpose-built in vivo CRISPR technologies for common, broadly prevalent diseases - starting with cardiometabolic disorders. Co-founder and CSO Dr. Jennifer Doudna, 2020 Nobel Laureate in Chemistry and foundational discoverer of CRISPR-Cas9 (her Nobel was announced the day after Scribe disclosed its first $20M round). Co-founder and CEO Dr. Benjamin Oakes, Doudna's former student. Bet on: three Tier-1 pharma partners underwriting the platform with capital at Phase 1 - Sanofi ($1.5B biobucks deal + $7.5M cornerstone investment in this IPO), Eli Lilly (indicated interest in buying IPO shares), Biogen (foundational 2020 partnership) + ELXR, a proprietary epigenetic silencing technology that switches off gene expression without cutting DNA - reversible, and a cleaner safety profile than base editing after Verve Therapeutics' Phase 1 safety scare cooled cardiovascular gene-editing sentiment in 2024-2025 + lead candidate STX-1150 (PCSK9, cholesterol) already in Phase 1 in Australia, first data expected H1 2027 + preclinical data: up to 68% LDL-C reduction from a single dose, durability past 22 months in primates. 📊 Key terms - Price range: $13-15 per share - Shares: 7,100,000 + overallotment option 1,000,000 (30-day) - Net IPO proceeds: ~$96.2M at midpoint $14, ~$110.2M with full option - Concurrent private placement: Sanofi, ~$7.5M at IPO price (cornerstone investor) - Total combined raise: ~$117.7M - Market cap: ~$1.38B at midpoint $14 (fully diluted) - Exchange: Nasdaq Global Market | Ticker: SCTX - Pricing: July 23, 2026 | Trading: July 24, 2026 - Lock-up: 93 days 💰 Financials - Revenue: $0 - pre-revenue clinical-stage company - Cash and equivalents (Mar 31, 2026): $49.7M | accumulated deficit: $175.1M - Q1 2026 net loss: $17.4M (annualized ~$69.6M) | going concern flagged without IPO proceeds - Post-IPO runway at current burn: ~6 quarters, through Q4 2027-Q1 2028 - covers the STX-1150 Phase 1 data readout - Valuation: Price/Revenue N/A (pre-revenue); $1.38B market cap against Sanofi's $1.5B biobucks deal plus Lilly interest - reasonably priced for a Phase 1 CRISPR cardiovascular name with Tier-1 pharma backing 🎯 Thesis Scribe is a platform bet, not a single-asset bet - three major pharma partners have already put capital behind the CRISPR by Design and ELXR technology before any human efficacy data exists. The differentiation from Verve (base editing, permanent DNA change) to ELXR (epigenetic, reversible) is the safety argument the company is selling, and it lands better after Verve's own Phase 1 scare. Key risk: pre-revenue with an 18-month runway to the first real data point - if STX-1150's Phase 1 readout in H1 2027 disappoints, there's no revenue base to fall back on. 🏛️ Joint lead bookrunners: Leerink Partners, Goldman Sachs. Joint bookrunners: Guggenheim Securities, Wells Fargo Securities. 📅 Deadline: July 23, 2026 (inclusive) 📲 Explore the deal in the Fintch app: https://t.co/CqMT1GPNnI

0

2

0

214

Cassiopeia @Tortue_73

about 3 years ago

...wie schwer es oft auch, besonders in den ersten Monaten und Jahren nach der #SCTx 2002 gefallen ist. Vor der DCIS-bedingten Strahlentherapie 2022, sind wir von Mürzzuschlag übers Stuhleck auf den Semmering gewandert. Heute haben wir vor, ... 4/n

1

2

0

47

Ann

@AnnHd04

about 3 years ago

Great way to start the Memorial weekend!☕️🤩 #sctx #txwx

0

9

1

0

314

Cassiopeia @Tortue_73

over 3 years ago

Das Foto ist vom September 2002. Gestern war Muttertag und morgen ist mein 21. Zweiter Geburtstag (#SCTx) Als ich damals nach über 4 Monaten im LKH Graz endlich wieder heim durfte, kannte mich mein Kind nicht mehr als seine Mama. Kein Wunder nach den vielen Monaten und... 1/3

Tortue_73's tweet photo. Das Foto ist vom September 2002.
Gestern war Muttertag und morgen ist mein 21. Zweiter Geburtstag (#SCTx)
Als ich damals nach über 4 Monaten im LKH Graz endlich wieder heim durfte, kannte mich mein Kind nicht mehr als seine Mama.
Kein Wunder nach den vielen Monaten und...
1/3 https://t.co/nttHOZqHXw

2

8

0

318

Cassiopeia @Tortue_73

over 3 years ago

... wieder an die Zeit nach meiner #SCTx erinnert, als das Leben auch wieder normaler wurde, auch damals im Wissen, dass ein Risiko bleibt. Aber irgendwann überwiegen in der Abwägung andere Gründe. Das ist dann das Loslassen, das Loslassen von fast 100%iger Sicherheit. 9/13

1

0

102

Mary Wasson @Mary_Wasson

over 3 years ago

If you have plans to camp this weekend in #ctx and #sctx make sure you get to higher ground if a warning is issued. #txwx #texas

NWS Austin/San Antonio @NWSSanAntonio

over 3 years ago

Camping plans this weekend? Be aware that there is the potential for flash flooding and river flooding! Plan a place to go if you are alerted to flooding at your location and stay informed of weather conditions. Never walk or drive through flood waters! #txwx

NWSSanAntonio's tweet photo. Camping plans this weekend? Be aware that there is the potential for flash flooding and river flooding! Plan a place to go if you are alerted to flooding at your location and stay informed of weather conditions. Never walk or drive through flood waters! #txwx https://t.co/uxHBG1mGdM

1

24

9

0

14K

0

1

0

311

Cassiopeia @Tortue_73

over 3 years ago

Vieles kann ich aus meiner Zeit nach der #SCTx aus eigener Erfahrung und auch aus der Erfahrung von Mitpatient:innen nachvollziehen. #MECFS gibt es ja nicht nur postviral sondern ist oft auch nach überstandenen Krebserkrankungen ein wichtiges Thema.

0

2

0

54

Cassiopeia @Tortue_73

over 3 years ago

Warum ich mich zum Thema #vulnerabel äußere: Diese Polaroid wurde von einer DKS im Mai 2002 um die Zeit meiner #SCTx in der KMT-Einheit des LKH Graz aufgenommen. Meine Lunge drohte damals zu kollabieren, deshalb die CPAP-Maske. Ich war vom 14.2. bis 22.6. durchgehend... 1/16

Tortue_73's tweet photo. Warum ich mich zum Thema #vulnerabel äußere:
Diese Polaroid wurde von einer DKS im Mai 2002 um die Zeit meiner #SCTx in der KMT-Einheit des LKH Graz aufgenommen.
Meine Lunge drohte damals zu kollabieren, deshalb die CPAP-Maske.
Ich war vom 14.2. bis 22.6. durchgehend...
1/16 https://t.co/KVa0IWkcFe

2

0

Cassiopeia @Tortue_73

over 3 years ago

...jeder Geburtstag meines Sohnes für mich selbst das größte Geschenk ist, weil ich entgegen aller Prognosen noch immer dabei bin 😇🙏, hab ich mich zur Feier des Tages auch beschenkt. 😅 Ihr erinnert euch, wie sich mein LG gegen das eine gewehrt hat. 🤭 #AML #SCTx

Tortue_73's tweet photo. ...jeder Geburtstag meines Sohnes für mich selbst das größte Geschenk ist, weil ich entgegen aller Prognosen noch immer dabei bin 😇🙏, hab ich mich zur Feier des Tages auch beschenkt. 😅
Ihr erinnert euch, wie sich mein LG gegen das eine gewehrt hat. 🤭
#AML #SCTx https://t.co/5E55YznTrf

1

7

0

127

Mary Wasson @Mary_Wasson

over 3 years ago

We've made some major improvements over the last 6 months but unfortunately January has started dry with only .07" so far (-1.80") but we have some significant rain on the way next Tuesday. Keep your fingers crossed! #txwx #ctx #sctx

Mary_Wasson's tweet photo. We've made some major improvements over the last 6 months but unfortunately January has started dry with only .07" so far (-1.80") but we have some significant rain on the way next Tuesday. Keep your fingers crossed! #txwx #ctx #sctx https://t.co/KNt7RgnmEH

1

2

1

0

373

Mary Wasson @Mary_Wasson

over 3 years ago

2022 goes down as the 29th driest year on record for Austin with only 72 days with measurable rain. A total of 26.59" fell and that was almost 10" below normal. Our drought has improved but we still have a ways to go in the Hill Country. #txwx #sctx #ctx #austin

Mary_Wasson's tweet photo. 2022 goes down as the 29th driest year on record for Austin with only 72 days with measurable rain. A total of 26.59" fell and that was almost 10" below normal. Our drought has improved but we still have a ways to go in the Hill Country. #txwx #sctx #ctx #austin https://t.co/CiGxgCDKRB

0

3

0

695

Doug Currin @DougCurrin

about 4 years ago

STOPPED: exits 82-92 EB 20. All lanes closed. Off ramps are the only way out. Avoid Avoid Avoid!! ⁦@abc_columbia⁩ #SCTX #ABCColumbia #SCTraffic

DougCurrin's tweet photo. STOPPED: exits 82-92 EB 20. All lanes closed. Off ramps are the only way out. Avoid Avoid Avoid!! ⁦@abc_columbia⁩ #SCTX #ABCColumbia #SCTraffic https://t.co/pskuogPbFZ

0

5

0

Mary Wasson @Mary_Wasson

over 4 years ago

Guess what? Next week we could FINALLY see a good chance of rain across the Lone Star State. #txwx #ctx #sctx #ntx #texas #texasweather

Mary_Wasson's tweet photo. Guess what? Next week we could FINALLY see a good chance of rain across the Lone Star State. #txwx #ctx #sctx #ntx #texas #texasweather https://t.co/2OTox4nntw

0

3

1

0

Mary Wasson @Mary_Wasson

almost 5 years ago

Heavy rain is ongoing across Central and South Texas. Some localized flooding is possible at times. We could also see some lightning mixed in as well. #txwx #ctx #sctx

Mary_Wasson's tweet photo. Heavy rain is ongoing across Central and South Texas. Some localized flooding is possible at times. We could also see some lightning mixed in as well. #txwx #ctx #sctx https://t.co/mabOjCiqBu

0

2

0

Mary Wasson @Mary_Wasson

almost 5 years ago

Hold on to your hats out there! #ctx #sctx

NWS Austin/San Antonio @NWSSanAntonio

almost 5 years ago

Windy conditions are developing across South Central Texas. Here are the noon hour wind gusts being reported. 🌬️

0

21

8

0

2

0

Mary Wasson @Mary_Wasson

about 5 years ago

We've had pockets of 3" - 6" of rain across Central and South Central Texas. 24 HR Rain Totals: Seguin - 6.35" Fair Oaks Ranch - 5.18" Geronimo - 4.73" Twin Sisters - 4.22" #txwx #ctx #sctx #flashfloodalley

Mary_Wasson's tweet photo. We've had pockets of 3" - 6" of rain across Central and South Central Texas.
24 HR Rain Totals:
Seguin - 6.35"
Fair Oaks Ranch - 5.18"
Geronimo - 4.73"
Twin Sisters - 4.22"
#txwx #ctx #sctx #flashfloodalley https://t.co/2yPOoOzMdV

0

3

0

Mary Wasson @Mary_Wasson

over 5 years ago

Here's what we can expect the next few days... #txwx #CTX #SCTX #NTX #Dallas #FortWorth #Waco #Austin #SanAntonio #CorpusChristi #Laredo

Mary_Wasson's tweet photo. Here's what we can expect the next few days... #txwx #CTX #SCTX #NTX #Dallas #FortWorth #Waco #Austin #SanAntonio #CorpusChristi #Laredo https://t.co/gIkBusIBUE

0

6

4

0

Mary Wasson @Mary_Wasson

over 5 years ago

This was around 8 pm in South #Austin. Waiting for the heavy snow bands to move in any second ... #ctx #sctx #txwx

1

5

1

0

Mary Wasson @Mary_Wasson

over 5 years ago

Bridges, overpasses and elevated surfaces are the first to freeze when we are talking about winter storms. #txwx #ntx #ctx #sctx #texasweather Here's why...

Mary_Wasson's tweet photo. Bridges, overpasses and elevated surfaces are the first to freeze when we are talking about winter storms. #txwx #ntx #ctx #sctx #texasweather Here's why... https://t.co/F10iAZ9mY9

0

3

1

0

Mary Wasson @Mary_Wasson

over 5 years ago

A Winter Storm Warning and a Winter Weather Advisory are in effect for Central and South Central Texas through the evening. Stay off the roads ... they WILL be icy. #txwx #ctx #sctx

Mary_Wasson's tweet photo. A Winter Storm Warning and a Winter Weather Advisory are in effect for Central and South Central Texas through the evening. Stay off the roads ... they WILL be icy. #txwx #ctx #sctx https://t.co/mc8aKfqmg2

0

2

0

Top Tweets for #SCTx

Last Seen Hashtags on Sotwe

Trends for you

Most Popular Users