Top Tweets for #sctx
🧬 New IPO: Scribe Therapeutics (#SCTX)
A new IPO is now available in the Fintch app.
Scribe Therapeutics is an Alameda, California clinical-stage biotech founded in 2017, developing purpose-built in vivo CRISPR technologies for common, broadly prevalent diseases - starting with cardiometabolic disorders. Co-founder and CSO Dr. Jennifer Doudna, 2020 Nobel Laureate in Chemistry and foundational discoverer of CRISPR-Cas9 (her Nobel was announced the day after Scribe disclosed its first $20M round). Co-founder and CEO Dr. Benjamin Oakes, Doudna's former student.
Bet on: three Tier-1 pharma partners underwriting the platform with capital at Phase 1 - Sanofi ($1.5B biobucks deal + $7.5M cornerstone investment in this IPO), Eli Lilly (indicated interest in buying IPO shares), Biogen (foundational 2020 partnership) + ELXR, a proprietary epigenetic silencing technology that switches off gene expression without cutting DNA - reversible, and a cleaner safety profile than base editing after Verve Therapeutics' Phase 1 safety scare cooled cardiovascular gene-editing sentiment in 2024-2025 + lead candidate STX-1150 (PCSK9, cholesterol) already in Phase 1 in Australia, first data expected H1 2027 + preclinical data: up to 68% LDL-C reduction from a single dose, durability past 22 months in primates.
📊 Key terms
- Price range: $13-15 per share
- Shares: 7,100,000 + overallotment option 1,000,000 (30-day)
- Net IPO proceeds: ~$96.2M at midpoint $14, ~$110.2M with full option
- Concurrent private placement: Sanofi, ~$7.5M at IPO price (cornerstone investor)
- Total combined raise: ~$117.7M
- Market cap: ~$1.38B at midpoint $14 (fully diluted)
- Exchange: Nasdaq Global Market | Ticker: SCTX
- Pricing: July 23, 2026 | Trading: July 24, 2026
- Lock-up: 93 days
💰 Financials
- Revenue: $0 - pre-revenue clinical-stage company
- Cash and equivalents (Mar 31, 2026): $49.7M | accumulated deficit: $175.1M
- Q1 2026 net loss: $17.4M (annualized ~$69.6M) | going concern flagged without IPO proceeds
- Post-IPO runway at current burn: ~6 quarters, through Q4 2027-Q1 2028 - covers the STX-1150 Phase 1 data readout
- Valuation: Price/Revenue N/A (pre-revenue); $1.38B market cap against Sanofi's $1.5B biobucks deal plus Lilly interest - reasonably priced for a Phase 1 CRISPR cardiovascular name with Tier-1 pharma backing
🎯 Thesis
Scribe is a platform bet, not a single-asset bet - three major pharma partners have already put capital behind the CRISPR by Design and ELXR technology before any human efficacy data exists. The differentiation from Verve (base editing, permanent DNA change) to ELXR (epigenetic, reversible) is the safety argument the company is selling, and it lands better after Verve's own Phase 1 scare. Key risk: pre-revenue with an 18-month runway to the first real data point - if STX-1150's Phase 1 readout in H1 2027 disappoints, there's no revenue base to fall back on.
🏛️ Joint lead bookrunners: Leerink Partners, Goldman Sachs. Joint bookrunners: Guggenheim Securities, Wells Fargo Securities.
📅 Deadline: July 23, 2026 (inclusive)
📲 Explore the deal in the Fintch app:
https://t.co/CqMT1GPNnI
...wie schwer es oft auch, besonders in den ersten Monaten und Jahren nach der #SCTx 2002 gefallen ist.
Vor der DCIS-bedingten Strahlentherapie 2022, sind wir von Mürzzuschlag übers Stuhleck auf den Semmering gewandert.
Heute haben wir vor, ...
4/n
Das Foto ist vom September 2002.
Gestern war Muttertag und morgen ist mein 21. Zweiter Geburtstag (#SCTx)
Als ich damals nach über 4 Monaten im LKH Graz endlich wieder heim durfte, kannte mich mein Kind nicht mehr als seine Mama.
Kein Wunder nach den vielen Monaten und...
1/3
... wieder an die Zeit nach meiner #SCTx erinnert, als das Leben auch wieder normaler wurde, auch damals im Wissen, dass ein Risiko bleibt.
Aber irgendwann überwiegen in der Abwägung andere Gründe. Das ist dann das Loslassen, das Loslassen von fast 100%iger Sicherheit.
9/13
Camping plans this weekend? Be aware that there is the potential for flash flooding and river flooding! Plan a place to go if you are alerted to flooding at your location and stay informed of weather conditions. Never walk or drive through flood waters! #txwx
Warum ich mich zum Thema #vulnerabel äußere:
Diese Polaroid wurde von einer DKS im Mai 2002 um die Zeit meiner #SCTx in der KMT-Einheit des LKH Graz aufgenommen.
Meine Lunge drohte damals zu kollabieren, deshalb die CPAP-Maske.
Ich war vom 14.2. bis 22.6. durchgehend...
1/16
STOPPED: exits 82-92 EB 20. All lanes closed. Off ramps are the only way out. Avoid Avoid Avoid!! @abc_columbia #SCTX #ABCColumbia #SCTraffic
Windy conditions are developing across South Central Texas. Here are the noon hour wind gusts being reported. 🌬️
We've had pockets of 3" - 6" of rain across Central and South Central Texas.
24 HR Rain Totals:
Seguin - 6.35"
Fair Oaks Ranch - 5.18"
Geronimo - 4.73"
Twin Sisters - 4.22"
#txwx #ctx #sctx #flashfloodalley
Here's what we can expect the next few days... #txwx #CTX #SCTX #NTX #Dallas #FortWorth #Waco #Austin #SanAntonio #CorpusChristi #Laredo
Bridges, overpasses and elevated surfaces are the first to freeze when we are talking about winter storms. #txwx #ntx #ctx #sctx #texasweather Here's why...
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