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Here’s some modelling you may find interesting. Histamine is one of the signals which tells the liver to phosphorylate glycogen and send glucose to the muscles, etc. (glycogenolysis, gluconeogenesis) There are other signals which perform a similar role under different circumstances - eg. cortisol, T3 and adrenaline. Insulin is a largely opposing signal. These signals may have relationships with meals, sleep, time of day, sympathetic compensation, metabolic crises. ADHD medications often promote sympathetic tone. In the absence of appropriate levels of other signals and related parasympathetic metabolism, the sympathetic tone and mast cells, etc may increasingly play compensatory roles. This has implications for MCAS, etc, also. You can see more of this using your own or example data, here - https://t.co/GExaQxnkkL