Top Tweets for #SingleCellImaging
Yes, in principle there are no restrictions on the types of comparative analyses we can perform between single-cell imaging (#singlecellimaging) and single-cell sequencing (#singlecellsequencing) platforms. We have the flexibility to do a wide range of comparisons…from straightforward metrics like cost per gene detected, to more nuanced ones such as cost per gene not detected (i.e., missed targets with potential biological significance), or cost per gene detected but ultimately irrelevant to the study question.
We went into that rabbit hole and in the end, it’s a matter of what metrics helps you decide what way to go.
While sequencing is often marketed as “unbiased”, in practice, that’s a bit of a misnomer…the readout reflects biases in capture efficiency, amplification, and transcript abundance. Imaging, by contrast, is targeted by design, but that targeting enables higher confidence and spatial fidelity per transcript at much lower noise levels. So, comparisons must go beyond simple detection rates…we need to consider biological relevance, false discovery rates, and cost-efficiency across practical use cases.
Single-Cell, Spatial Omics Technologies Improve Rapidly in 2024 as Market Expansion Slows, by Andrew P. Han
Thank you for the shoutout to #STAMP!
#singlecellimaging
@DrJasPlummer @hoheyn
@EmanuelePitino1 @AnnaPascua16627 @Kellieiswise @ximbaozao @irepan_salvador @helucro @eliseinsing Bill Flynn.
@brukerspatial @10xGenomics @ACEpigenetics @StJudeResearch @UniofAdelaide @cnag_eu @SAiGENCI
https://t.co/AVQNFeDohc
@ScienceLab_MCBI @CancerCenterAms @AIIresearch @Ernestorcp @lotte_dewinde @F_vanMaldegem @amsterdamumc Ready for #singlecellclub
@ScienceLab_MCBI?
😀Excited to hear from @EgleKvedaraite (@karolinskainst) on human mononuclear phagocytes in tissue using #scRNAseq, #flowcytometry✨ & #imaging, and @ColliverEmma (@TheCrick) on the PHLEX computational toolkit for #singlecellimaging 🔬
#AvailableForLicensing: Harness the insights of #metabolomics with the resolution of #singlecellimaging with this #metabolomicanalysis that identifies different cell types in #cancertumor biopsies & complex tissue types like #lymphatictissues. @CoulterBME
https://t.co/dbAZJxuI4s
Welcome to the 6th day of 12 Days of NanoString! Interested in leaping to single-cell spatial in these applications? https://t.co/c09Qwvt3JH
#SpatialData #CellSegmentation #SpatialTranscriptomics #SingleCellImaging
Good coverage in The West and @BullsNBearsWA today.
Learn more: https://t.co/pF029fqeWZ
#digitalpatholology #imageguidedsurgery #singlecellimaging #imaginethepossibilities #thewest #optiscanimaging #invivage
A money trail is forming behind @Optiscan technology-based mission to tackle the scourge of #cancer, with revenue starting to stream into the company’s coffers from the lucrative Chinese health sector.
$OIL #BULLSNBEARSWA #ASX #MedTech @westaustralian
https://t.co/dSly21TfQe
#FeaturedTechnology: Harness the insights of #metabolomics with the resolution of #singlecellimaging with this #metabolomicanalysis that identifies different cell types in #cancertumor biopsies & complex tissue types like #lymphatictissues. @CoulterBME
https://t.co/dbAZJxuI4s
🚀Explore the power of 6,000 Genes with CosMx SMI. https://t.co/naojq5YkV7
CosMx SMI is the FIRST spatial imager to generate a dataset with over 6,000 genes. 🧠The new open-source Human Frontal Cortex Tissue dataset is available now!
#SingleCellImaging #SpatialBiology
It’s simple math. Higher Plex = More Biology It’s simple, and the CosMx Human 6K Discovery Panel will offer the highest plex available. https://t.co/naojq5YSKF #SingleCellImaging #SpatialData #FFPEtissue
📢Draw biologically impactful hypotheses from your Spatial data! https://t.co/4kGtvrs4gz 📷Read our newest White Paper, Evaluating the Technical Performance of Single-Cell Spatial Molecular Imaging Technologies. #SpatialBiology #SingleCellImaging #Science #singlecellspatial
Join us for an exciting webinar on August 24, 2023, where we'll uncover subtype-specific heterogeneity in brain cancer with GeoMx DSP and CosMx SMI https://t.co/NDu6nkAdjB.
🕚 Mark your calendars:
11 AM CEST
3 PM PDT, with LIVE Q&A
#spatialmultiomics #singlecellimaging
Have you seen 👀 the New CosMx SMI Mouse Brain FFPE dataset 🐭🧠? Uncover the mysteries of the mouse brain with CosMx SMI and take the Leap to Single-cell Spatial! https://t.co/O1AjFJkQfj
#Neuroscience #MouseBrain #singlecellimaging
#AvailableForLicensing: Harness the insights of #metabolomics with the resolution of #singlecellimaging with this #metabolomicanalysis that identifies different cell types in #cancertumor biopsies & complex tissue types like #lymphatictissues. @CoulterBME
https://t.co/dbAZJxuI4s
Oh wow!
Impressive work from the @N_Rajewsky lab who used CosMx SMI to build this high-resolution molecular atlas of a lung tumor in 3D 👇
#singlecellimaging #spatialtranscriptomics #lungtumor
https://t.co/UL9ynJqMWY
2/
For this proof-of-principle we focused on a routine FFPE lung cancer case (@FKlauschen @AIgnostics) and combined high-resolution spatial transcriptomics (CosMx @nanostringtech) with imaging-based readouts of tissue biomechanics (SHG) and protein markers (IF @CosciaLab)
How do you maximize #throughput in #singlecell imaging experiments?
Learn what to consider when selecting an #instrument or CRO partner for single-cell imaging: https://t.co/FfNlwS9IR2
#spatialbiology #multiplexedimaging #immunophenotyping #singlecellimaging #fluorescence
Thrilled to present today at the University of British Columbia's School of Biomedical Engineering on our work on computational pathology and AI.
https://t.co/Mex0cYfjBG
#ai #digitalpathology #aiinhealthcare #medicalai #singlecellimaging #molecularimaging
"Spatial insights into Tumor Immune Evasion Illuminated with the CosMx Spatial Molecular Imager Platform," 😮 poster now LIVE at #SITC22 #SingleCell, #SingleCellImaging, #CellImaging
What can you do with data from 800,000 single cells? See the power of CosMx Spatial Molecular Imager and engage with our FFPE data-set on Non-small cell lung cancer.
https://t.co/MABM8TpUeX
#SingleCellImaging #SpatialMultiomics #SpatialTranscriptomics
CosMx Spatial Molecular Imager delivers what you've come to expect from @NanoStringTech. Accurately detect and quantify RNA and protein in situ on FFPE tissue. https://t.co/WNh4QEZuTW
#SpatialTranscriptomics #SingleCell #FFPE #SingleCellImaging
Elevate your single-cell research with high-plex, in situ spatial context. The CosMx Spatial Molecular Imager is now available to revolutionize your single-cell and spatial biology research! https://t.co/QeEpfiNWUu
#SingleCellImaging #SpatialMultiomics #SpatialTranscriptomics
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