Top Tweets for #Spirochete
Thanks to @donaldsmann's Eagle eyes! #Ticks are on the roadmap!
#Ticks #Spirochete #Pathogen #Vector #Bacteria #Endocannabinoid #Anandamide #Pam3Cys #Pam3Cyslike #Spike #OuterMembraneProtein #TLR #Lyme #Alphagal #Sickness #illness #Bug #Disease #DNA #RNA #DNAOS

Do you know that #termite guts are a hotspot of #spirochete diversity?
Some of the spirochetes get really big, more than 100 µm. Some have become associated with termite #protists and in extreme cases play the role of movement "organelles" (#flagellate Mixotricha paradoxa in termite Mastotermes darwiniensis) 🤓.
#microbiology #bacteria #eukaryotes
@BioMedCentral
https://t.co/0NdKkizn3s

In my book The Sleeper Agent i have linked the origins of #Lymedisease to #ErichTraub, he acquires the #spirochete in 1939 the same year he learns to incorporate all the same co-infections into one #tick. He spread it in #Germany first then brought it to #America in #ProjectPaperclip and released it at #PlumIsland in the years 1949-1951. By 1953, the USDA was meeting in conferences about biowarfare on the poultry industry stating that they believe we were attacked with "foreign animal diseases" and one agent they listed of concern was Borrelia anserina (avian spirochetosis) which is where Borrelia burgdorferi came from. #Spirochetes start show up in M. S. patients in the 1950s, and the black-legged tick is listed for the first time as a serious transmitter of human disease in some newspaper articles by 1958. Allen Steere also published a paper linking early cases of Lyme disease in 1962. But Polly Murray who wrote The Widening Circle shows that she got sick in the 1950s and by 1960s was fully debilitated. https://t.co/sI2O1OK4cD
@AWFinnegan Tell them how it is...Lyme is trending. The Spirochete and Pam3-Cys like lipids can be beaten with #AllicinV. #Lyme #Spirochete #Pam3Cys
The paper "Antigenic sites in SARS-CoV-2 spike RBD show molecular similarity with pathogenic antigenic determinants and harbors peptides for vaccine development" by Tikam Chand Dakal was forwarded to us by A.W. Finnegan the author of the book "The Sleeper Agent." ( https://t.co/eLcE0N3R4g ) He has #Lyme disease and has had #Covid19 . This paper illustrates the 2D homology to the 3D protein structural similarities of 9 antigenic protein sites in the #SARSCov2 #Spike protein relative to 54 antigenic determinants found in twelve pathogenic bacterial species (Mycobacterium tuberculosis, Mycobacterium leprae, Bacillus anthracis, Borrelia burgdorferi, Clostridium perfringens, Clostridium tetani, Helicobacter Pylori, Listeria monocytogenes, Staphylococcus aureus, Streptococcus pyogenes, Vibrio cholera and Yersinia pestis), two malarial parasites (Plasmodium falciparum and Plasmodium knowlesi) and influenza virus A. We expect to have immunological response similarities between these pathogens in terms of human toxicity. In the case of the disulfide bridge outer membrane protein structure functionality that must be conserved, we are hopeful that we can expose new antibody targets with #Allicin in the Borrelia burgdorferi OSP c outer membrane protein similar to how we are able to do this in the #Coronavirus family of 40,001 viruses found in #GENBANK by disrupting the conserved disulfide bridges across the Cysteines shown in yellow in the 3D protein crystal structures in this Thread. #AllicinV #SARS #Covid
https://t.co/DrVIwgIZTD

You can listen to Dr. Perez speak at the 4hr 30 min mark speak about #AllicinV and the Spike protein Biochemistry relative to building learned immunity. #Covid #Covid19 #Vaccines #Biochemistry #MolecularGenetics #mRNA #SV40 #Lyme #Spirochete

It is true that if you have an existing disease in your Genome #Lyme will make it prevalent (express it Phenotypically). The current #Scientific literature shows that both the #Spike protein from #SARSCov2 (and all #Coronaviruses) and the Outer membrane of the #Spirochete are very similar in architecture. (1) They are sugar coated (glycosylated) so your body can't make antibodies properly to them. (2) They wobble in protein sequence during creation (translation). (3) They have conserved disulfide bridges that are critical to protein 3D structure and function as shown below. (4) They have Toll Like Receptor #TLR immunological function that overlaps relative to pathogenicity. All of that combined with the modified sulfur bond in the Pam-3-Cys Like lipid bound to the Spike and Spirochete outer membranes which is postulated based on textbook #Organic #Chemistry to be broken are factors that must be taken into consideration relative to breaking these pathogenic proteins open with #Allicin so that the human body can produce monoclonal antibodies to the newly exposed #Epitopes (antibody targets) allowing the the body to learn full immunity to the pathogen and thus participate in the detoxification of the pathogen a long with the allicin breakdown of pathogenic function. Those antibiotics mentioned just work on bacteria and antibiotics themselves can not be taken permanently to shield the body like #AllicinV from future infection. The last piece is understanding the bioavailability of the molecule being used to fight these pathogens. Allicin can not be properly administered orally, because it is degraded in the GI tract. Any oral treatment takes ~48 hours for full digestion. Intravenous (IV) treatment never reaches the surface of the lungs because the Allicin is absorbed by the tissues of the lungs and the liver. In order to fully coat the surface of the lungs in a monolayer of allicin molecules in ~1 millisecond you must use vapor technology. That is 100,000,000x faster to the lungs relative to any viral, bacterial, or microbial pathogen that can reside or infect lung tissue via the same airborne path. That is where you shield infection for respiratory born infections. The pulmonary path to the circulatory system and the heart is ~2-3 milliseconds later, and then to the brain a few more milliseconds. This is critical relative to getting the allicin Bioavailability into the path of airborne pathogen transport by the same human circulatory system. It is also critical to get the allicin into these locations at that speed in order to do immediate work. All of this has to do with #Physics and the #Physical #Chemistry of a real gas applied to a biological system that prefers Oxygen relative to #DNA & #RNA coded pathogens. When you detox of these code bases the diseases that you may have will become more manageable and treatable. Unless of course those disease are completely brought on by these types of pathogens. In that case you will go into remission. More transparent data is needed in these areas of #Science. Interesting that the origin of Lyme is a lot like Sars Cov2. Lab born.

@elonmusk We need the ability for @Grok to help us with the other identified pathogenic proteins that we have 3D models of in PDB relative to known published research in these areas. Like Outer Surface Membrane Protein C of Borreliella burgdorferi (#Lyme disease #spirochete). Until now, humanity did not have the #AI utility computing power to be able to intellectually interact with the information for the sake of interpreting the Physics. Leveraging the computing ability to know 3D Protein structural comparisons, Solvent accessible surface area (SASA) calculations, etc. about these protein structures gives humanity the chance to level the playing field in a battle that is complex and sophisticated relative to humanity's general population comprehension. cc: @Judyth
The 3D protein model of the Outer Surface Membrane Protein C of Borreliella burgdorferi (#Lyme disease #spirochete) as published in the cited paper in the thread shows the disulfide bridges in yellow. These are accessible to #Allicin based on the protein 3D structures we've looked at tied to eh #Spike & #Envelope proteins of #Coronaviruses as well as #Telomerase. They look exposed to surface attack as well as folding translation attack which can be kinetically throttled by making the UGA stop codon fail with Selenocysteine concentration (Ethan Taylor et. al.). #AllicinV #LymeDisease
The 3D protein model of the Outer Surface Membrane Protein C of Borreliella burgdorferi (#Lyme disease #spirochete) as published in the cited paper in the thread shows the disulfide bridges in yellow. These are accessible to #Allicin based on the protein 3D structures we've looked at tied to eh #Spike & #Envelope proteins of #Coronaviruses as well as #Telomerase. They look exposed to surface attack as well as folding translation attack which can be kinetically throttled by making the UGA stop codon fail with Selenocysteine concentration (Ethan Taylor et. al.). #AllicinV #LymeDisease
#Allicin is well published to disrupt #disulfide bridge formation in pathogenic proteins. This is especially the case in outer membrane proteins that leverage disulfide bridges for integrity. The Borrelia burgdorferi Outer Surface Protein C when produced in mass translation for this pathogenic bacteria must form the disulfide bridges during 2D to 3D folding. This type of observed pathogenic behavior is observed in a variety of #Spike protein viruses as well as #Telomerase the enzyme responsible for maintaining #Cancer cell programming. During folding the kinetics can be throttled back with Selenocysteine stop codon inhibition, slowing the folding process and making it even easier for Allicin attack of the disulfide bridges in the unfolded pathogen protein. This is an observation that has been published in the Scientific literature searchable on this thread. we have shown 3D models of #Spike & #Envelope proteins from the Swiss protein database as well as Telomerase 3D models with these disulfide bridge motifs that are conserved. We will find the outer membrane protein and post the 3D model for the outer surface protein C (OspC) from the #Lyme disease #spirochete, Borrelia burgdorferi. https://t.co/apCoxlzUmb

Drs Martin Strnad, Nobuo Koizumi, Shuichi Nakamura, Marie Vancová & Ryan Rego discuss the roles of #spirochetal surface-exposed adhesive molecules in #spirochete #migration. @TickEurope @BiologyCentre @TohokuUniPR #Pathogenesis #Adhesion #Flagella
https://t.co/s2BH3afEHM

Halloween is in the air, and the media! #spirochete

Microscopy means pretty pictures. I am always amazed by what Borrelia shows me. #spirochete #microbiology

🔥 #nft mint alert 🔥
@shonyoruga had 918 mints in the last hour
https://t.co/P03BICGImK
#NFTCommunity #Spirochete #SIE
Here is where the #CDC claims #sexualTransmission of #lymeDisease doesn’t happen only-because they looked at “other animals” & claim it doesn’t happen in them. Did they study rabbits that do transmit #syphilis, a #spirochete like #lyme? & how tested them? https://t.co/lL4NAHazhF
THE only reason the #CDC lists for the claim #sexualTransmission isn’t a viable transmission route for #lymeDisease is that they looked at sex transmission in other animals. What animals? Rabbits? #lyme is a #spirochete like syphilis- so why wouldn’t it be transmitted sexually?
#TBDWG decided funding 2 learn about the #sexualTransmission of #lymeDisease isn’t warranted. MILLIONS have undiagnosed #lyme because #CDC & #IDSA told docs not 2 test & if they do, required they use a 71% false negatives test. To not know If it’s passed to partners of millions?
Wonderful work in @JBacteriology from Kurni Kurniyati @VCUdentistry and former @JunLiuLab member @ChangYunjie @YaleMed #spirochete #flagella Identification and Characterization of the Alternative σ28 Factor in Treponema denticola https://t.co/YWxg2HPQHL
A great paper in @MolMicroEditors from Kurni Kurniyati and Chunhao Li @VCUdentistry and former @JunLiuLab member @ChangYunjie @YaleMed #spirochete #flagella Transcriptional and functional characterizations of multiple flagellin genes in spirochetes https://t.co/E6nhpjGZST
Had a great time at the #GRC learning about the latest #spirochete research and meeting the awesome people doing it!
This week @Rojelio Mejia will also lecture on fascinating #spirochete diseases including #leptospirosis and relapsing fever (RF)! Did you know that there are at least 3 kinds of RF? 1. tick-borne RF (TBRF), 2. louse-borne RF (LBRF), and 3. Borrelia miyamotoi disease!
Many thanks to @PhilGuo1 @YaleWestCampus for excellent contributions in #spirochete #flagella Role of the major determinant of polar flagellation FlhG in the endoflagella‐containing spirochete Leptospira https://t.co/EkDnb1QJlM
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