#SpnS2 - Twitter Hashtag

ACS Publications Bio & Med Chem Content @ACSBioMed

over 2 years ago

Read in #JMedChem a study from @SantosLabVT which shows that blockade of #S1P transport with orally bioavailable #Spns2 inhibitor recapitulates lymphopenia characteristic of Spns2 null mice. @VTChemDept https://t.co/3WqyCypDP3

ACSBioMed's tweet photo. Read in #JMedChem a study from @SantosLabVT which shows that blockade of #S1P transport with orally bioavailable #Spns2 inhibitor recapitulates lymphopenia characteristic of Spns2 null mice. @VTChemDept

https://t.co/3WqyCypDP3 https://t.co/ol7lhpC8ao

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Webster Santos @santoslabVT

over 2 years ago

Congrats to Daniel and @KDunnavant on their discovery of #S1P transporter #Spns2 inhibitor. Potent, orally bioavailable & leads to lymphopenia. Collaboration with Lynch lab (@uvapharmacology) & @Biochem_Anne. Let's drug this!🙌 @VTChemDept @VT_Science https://t.co/PEYLA9vH4m

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Webster Santos @santoslabVT

over 2 years ago

Congrats to @santoslabVT PhD #29: Dr. Kyle Dunnavant @KDunnavant. He developed #S1P transporter #Spns2 inhibitors. Excellent drug hunter. 👏 @VTChemDept @VT_Science @FralinLifeSci @drugdisc_vt

santoslabVT's tweet photo. Congrats to @santoslabVT PhD #29: Dr. Kyle Dunnavant @KDunnavant. He developed #S1P transporter #Spns2 inhibitors. Excellent drug hunter. 👏 @VTChemDept @VT_Science @FralinLifeSci @drugdisc_vt https://t.co/LH406Zm0lw

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Webster Santos @santoslabVT

over 2 years ago

Preprint work with Kevin Lynch @uvapharmacology. We developed #Spns2 inhibitors and showed efficacy in #MultipleSclerosis mouse model + no cardiac & auditory side effects. Biomarker=lymphopenia. Builds a case for drugging #Spns2. @VTChemDept @VT_Science https://t.co/NRDwzxN54A

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Webster Santos @santoslabVT

over 2 years ago

Congrats to @santoslabVT PhD #28: Dr. Christopher Shrader. He is an #S1P transporter #Spns2 drug hunter. Great work 🙌 @VTChemDept @VT_Science

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Tranquility🪷✨ @Soulmates_J2

about 3 years ago

*TL cleanse* My early season boys 🥰❤️ #SpnS2 #Heart

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Webster Santos @santoslabVT

over 3 years ago

Daunting to talk after @hlatim and Julie Saba at #Lysophospholipid #LRMSRC @FASEBorg conference in Melbourne, Florida. But #sph kinase and #spns2 #S1P transporter to the rescue!

santoslabVT's tweet photo. Daunting to talk after @hlatim and Julie Saba at #Lysophospholipid #LRMSRC @FASEBorg conference in Melbourne, Florida. But #sph kinase and #spns2 #S1P transporter to the rescue! https://t.co/WoAVAFPtfm

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MedChemExpress

@MedChemExpress

over 3 years ago

#Cell: #Spns2 exports #S1P via facilitated diffusion. Moreover, Spns2 inhibitor 16d attenuates the transport activity by locking Spns2 in the inward-facing state. This provides a new perspective for us to develop advanced Spns2 inhibitors. https://t.co/CVHJtKARf7 #drugdiscovery

MedChemExpress's tweet photo. #Cell: #Spns2 exports #S1P via facilitated diffusion. Moreover, Spns2 inhibitor 16d attenuates the transport activity by locking Spns2 in the inward-facing state. This provides a new perspective for us to develop advanced Spns2 inhibitors.
https://t.co/CVHJtKARf7
#drugdiscovery https://t.co/QLTZpiKezt

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Webster Santos @santoslabVT

over 3 years ago

Congrats to @santoslabVT PhD #26: Dr. Ariel Burgio @arielburgioo. She is #spns2 drug hunter and boron methodology guru. Phenomenal work @VTChemDept I’m a proud PI. @VT_Science

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ACS Publications Bio & Med Chem Content @ACSBioMed

over 3 years ago

Potent 2-aminobenzoxazole inhibitors of #S1P transporter #Spns2 induces lymphopenia in mice and rats, which is a hallmark of Spns2 inhibition. @SantosLabVT @VTChemDept Read now in #JMedChem ➡ https://t.co/CzZZCQQn3Z

ACSBioMed's tweet photo. Potent 2-aminobenzoxazole inhibitors of #S1P transporter #Spns2 induces lymphopenia in mice and rats, which is a hallmark of Spns2 inhibition. @SantosLabVT @VTChemDept

Read now in #JMedChem ➡ https://t.co/CzZZCQQn3Z https://t.co/BmdHbzL4TM

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Webster Santos @santoslabVT

over 3 years ago

Congrats to @santoslabVT @arielburgioo for the most potent #S1P transporter (#Spns2) inhibitor. Check out its development and activity in mice and rats in JMedChem @ACSBioMed. Collaboration with Kevin Lynch @uvapharmacology. @VTChemDept @VT_Science https://t.co/qJ4iEQ6gAO

santoslabVT's tweet photo. Congrats to @santoslabVT @arielburgioo for the most potent #S1P transporter (#Spns2) inhibitor. Check out its development and activity in mice and rats in JMedChem @ACSBioMed. Collaboration with Kevin Lynch @uvapharmacology. @VTChemDept
@VT_Science https://t.co/qJ4iEQ6gAO https://t.co/6Xf6bgfdKv

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Tranquility🪷✨ @Soulmates_J2

over 3 years ago

#SpnS2 #WIaWSNB #J2sDay Jensen was brilliant in this episode but Jared was equally phenomenal. No noticeable visible changes and yet it's so very unmistakable: Sammy Not Sammy

Soulmates_J2's tweet photo. #SpnS2
#WIaWSNB
#J2sDay
Jensen was brilliant in this episode but Jared was equally phenomenal.
No noticeable visible changes and yet it's so very unmistakable:

Sammy Not Sammy https://t.co/my80e7Qc8Q

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Webster Santos @santoslabVT

about 4 years ago

Interested in learning about potential alternatives to #S1P1 agonists? Stop by W182. See how drugging #S1P transporter #spns2 could be therapeutics for MS & kidney fibrosis. @AcsMedi

santoslabVT's tweet photo. Interested in learning about potential alternatives to #S1P1 agonists? Stop by W182. See how drugging #S1P transporter #spns2 could be therapeutics for MS & kidney fibrosis. @AcsMedi https://t.co/01kPPMwtKA

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Linda Sasset @LindaSasset

over 5 years ago

Our last work is online! #Endothelial #Spns2 and #ApoM Regulation of #VascularTone and #Hypertension Via #S1P @Idelgaudio90 @ar_dilorenzo https://t.co/lFza3kbHtK

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Gene Of The Day @GeneOfTheDay

about 8 years ago

Today’s #GeneOfTheDay is #Spns2. Mice with this gene inactivated exhibit abnormal eye pigmentation & abnormal cornea morphology: https://t.co/qYS9UoqKZf