Top Tweets for #Subgroupanalysis
EMA vs IQWiG: Why Can Subgroup Analyses Lead to Different Conclusions?
https://t.co/ars8oXuRba
#Biostatistics #SubgroupAnalysis #HealthTechnologyAssessment #ClinicalTrials #ClinicalResearch #PharmaceuticalResearch #MarketAccess #Statswork
Different within-group significance does not prove subgroup effects differ. Credibility depends on interaction evidence, prespecification, rationale, multiplicity, sample size, effect estimates, and uncertainty.
#academicperfection #SubgroupAnalysis #InteractionTest #PeerReview
💡 T-DXd shows activity in HER2-expressing biliary tract/pancreatic cancer @ESMO_Open #DESTINYPanTumor02 #SubgroupAnalysis
👉 BTC: ORR 22.0%, up to 56.3% in HER2 IHC3+
👉 PC: ORR only 4.0%
👉 ILD/pneumonitis: 17.1% BTC vs 4.0% PC
DOI: https://t.co/A1ms9dn7UJ
@myESMO @ILCAnews @EASLnews
#TDXd #HER2 #BTC
Great thread from @MarionKCampbell on #SubgroupAnalysis - worth a read if you’re involved in #clinicaltrials
It is common to perform #SubgroupAnalysis as part of a trial, but they can be poorly executed & caution is often needed when interpreting them 1/9
#MethodologyMonday #52
It is common to perform #SubgroupAnalysis as part of a trial, but they can be poorly executed & caution is often needed when interpreting them 1/9
#MethodologyMonday #52
Thrilled to kick off our 2nd @apoddc #webinar series on #ClinicalTrialsDesign last #Friday w/ Profs Chee LEE & TAI Bee Choo provided valuable insights w/ initial primer on #statisticalconsiderations and deep dive in #subgroupanalysis. Over 100 attendees! Next mtg on April 28!
@drdangayach @caseyalbin @almuftifawaz @MDaware @aartisarwal @MountSinaiNCC @JMoccoMD @johannatfifi @chriskellnerMD @svinsociety @MountSinaiNeuro @AANMember @MonaBahouth @GPerue @DrDanAckerman Nice study with promising results which supports our current practice! However >80% of the subjects were M1 or M2 occlusion so question regarding IVT+EVT vs EVT alone in patients with tandem occlusion (or ICAT) remains undecided! #Subgroupanalysis
Only detective work by a pair of Philippine clinical epidemiologists revealed the distortions and hiding data by Sanofi. When revealed the result was a political and public health crisis in the Philippines. #subgroupanalysis https://t.co/NqxPi9RTny
@mmamas1973 @DBelardoMD @AnastasiaSMihai @ash71us @RodrigoBagur @nolanjimradial @Hragy @Libbyextra @biljana_parapid @ShelleyZieroth @cardiojaydoc02 @AChoiHeart @SABOURETCardio @mirvatalasnag @purviparwani @DrMarthaGulati @lamelaspablo @iamritu @Hinaheartdoc @avolgman @DrToniyaSingh @fischman_david @DocSavageTJU @BethFratesMD It’s a special delight to keep you in check, @mmamas1973!😉😂 #ProudlyPurist #KeepingItReal #SubgroupAnalysis #ClinicalTrials
@SMBCComics @ZachWeiner A significantly funny joke among your 4 panel comics featuring both a science and math theme driven by dialog between two male characters, one of whom is wearing glasses, during the period between February 7th, 2019 and the present day. (p = 0.0492)
#SubGroupAnalysis
Pitfalls of #subgroupanalysis: Don’t believe subgroup analysis if wasn’t prespecified or underpowered. Use interaction test, not within-group P-value. Adjust 4 multiplicity. Assess results for biological plausibility, external consistency #ESCCongress #LVEFinteraction @mmamas1973
Fantastic effort in completing the large @PRISM_trial @arricoomarasamy. How about #Bayesiananalysis using the results of PROMISE and PRISM? Check out the 'The Three Simple Rules' re #subgroupanalysis https://t.co/07BuZyYmZ6 @jimgthornton @f2harrell
1/
PRISM Trial out in the NEJM! 54 extra babies with progesterone, 3% difference in live birth, borderline statistical significance (P=0.08). Key subgroup effects identified. @TommysBham @Tommys_baby @IMSR_UoB @BhamCTU #miscarriage https://t.co/AklhJB3ceV
#EXCEL #subgroupanalysis shows that in #patients with #leftmain #CAD and #CKD, #PCI and #CABG had similar outcomes at 3 years, though PCI was associated with lower 30-day rates of #acuterenalfailure and #majoradverseevents. Stay tuned ... https://t.co/0uM2x1ZHSf
In the navigate trial patients with a pfo got more benefit from Rivioxoban than aspirin #ESOC2018 #subgroupanalysis pre specified so not p hacking
Seminar Reminder - Tomorrow Prof Fujian Song, JSC 3.02, 13.00-14.00 @UeaMed @UEA_Health #subgroupanalysis #rcts #medicalstatistics
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