Top Tweets for #Subretinal
A patient presents with a new onset of nAMD with #subretinal hemorrhage and a large pigment epithelial detachment. Join Hani Salehi-Had, MD, for a 15-minute CME course. https://t.co/7IhFn1vGgV
Scientists have developed a head-mounted, teleoperated surgical robot that can compensate for patients’ natural movements to enable precise #subretinal injections and #bleb formation. @URoboticsCenter
Learn more in Science #Robotics: https://t.co/iPxm5qJPwv
#artificial #retina #research with #PixiumVision is close to giving our #patients with dry #agerelated #macular #degeneration partial restoration of #vision
#subretinal #retinal #implant
#PositiveVibes
Honour to speak: The #Eye and The #chip world research congress #Detroit
@MyriamMarussig 4/#SPV06 is meant to be delivered via a #subretinal injection to the patient’s 👁️. Its payload is combined from a RdCVFL payload aimed to address oxidate stress & RdCVF which will be depleted in the #retina aimed to enable entry of Glucose to the retina when Rods will degenerate
3/A recent study, by @MyriamMarussig, showed that the use of #subretinal injection & #AAV to deliver RdCVF to stimulate glucose entry to the cones could very well lead to prevention of the loss of function of cones in #Retinitispigmentosa patients and thus preventing vision loss
9/At advanced RP stages, the patient’s #retina is thinner and a #Subretinal injection could be very risky. Therefore, a desirable injection route in patients is an #Intravitreal (IVT) injection, which is noninvasive to the #retina. In order to determine whether GIRK1 F137S could be delivered to human cones via an Intravitreal injection, an engineered IVT-permissive AAV2 variant (AAVi) was used to optimized the transducing retinal cells when delivered intravitreally.
8/A #Subretinal administration In rd10 mice of AAV8-GIRK1 F137S led to significant - but transient - functional improvements at 3 weeks after administration. A GIRK1 F137S protein was detected at the cell membrane of cones in AAV-treated rd10 retinas. Visual improvements were transient likely due to the low number of cones remaining at the later timepoints in this fast-progressing model.
Do you tolerate #subretinal fluid after RD repair? See what Stratos Gotzaridis, MD, had to say about it at the 51st Annual Aspen #RetinalDetachment Society Meeting: https://t.co/xIGxrUu7Lr | #ARDS2023
3/MGT009 appears to be safe & well-tolerated & demonstrated one adverse event profile that was anticipated & manageable. Most AEs were related to the #Subretinal delivery procedure & were transient and resolved without intervention. In addition there were no dose-limiting events.
2/The clinical study was composed of 3 parts: dose-escalation, pediatric dose-confirmation & an expansion phase. MGT009 was injected via a #subretinal #delivery in only one eye - adult patients received treatment at 3 doses & the pediatric cohort (n=3) with an intermediate dose
Frederic Aissani, MD, performs internal limiting membrane peel and #subretinal injection of tissue plasminogen activator (tPA) in the single eye of a 75-year-old woman with #myopic #staphyloma who experienced a sudden loss of vision. https://t.co/CVXbW3nhET
3/PRODYGY is a Phase I/II study to assess the safety, tolerability, efficacy & quality of life following a single #subretinal injection of #SPVN06 in the worst-seeing 👁️ of adult #patients with #RP due to a mutation in the RHO, PDE6A, or PDE6B #gene
The brilliant Dr Igor Kozak, Vitreoretinal Surgeon from @MoorfieldsUAE gave a great talk on the different surgical approaches in delivering therapeutic agents to the #retina for inherited retinal diseases #Intravitreal #Epiretinal #Subretinal & #Suprachoroidal delivery.
2/The primary objectives of the study: 1)evaluate the proportion of patients with subretinal #surgical #delivery of #OpRegen to target regions under the #retina (ii) The safety of #subretinal delivery as measured 3 months following surgery
Subretinal drusenoid deposits are strongly associated with coexistent high-risk vascular diseases. Read the article by Ledesma-Gil https://t.co/eoTWyP3nf6
#Ophthalmology #Vascular #risk_factors #AMD #Subretinal #drusen #Eye_research
#health #heart #eye
3/ATSN-101 is a #GeneTherapy product administrated via a #subretinal injection & is aimed to deliver a functional human GUCY2D to a patient’s #photoreceptors ATSN-101 is composed from #AAV5 #Capsid, Human #rhodopsin kinase promoter & a Human GUCY2D coding sequence👇
Herein, authors describe a case of a choroidal nevus that raised concern for malignancy following abrupt evolution with #subretinal and #subhyaloid hemorrhages. Read the complete case: https://t.co/7nL79nYv4N
4/A recent study, by @MyriamMarussig, showed that the use of #subretinal injection & #AAV to deliver RdCVF to stimulate glucose entry to the #cones could very well lead to prevention of the loss of function of cones in #Retinitispigmentosa patients and thus preventing #VisionLoss
4/In non-human #primates - #NHPs, $EDIT-103 had demonstrated nearly 100% (!) knockout of endogenous RHO, & the replacement RHO #gene produced over 30% of normal RHO #protein levels in the treated area of the #subretinal #injection.
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