Top Tweets for #TRPB
This is finally out in PNAS--a combinatorially complete sequence-function data set for the remarkable #enzyme #TrpB. PhD thesis work of Kadina @kadinaj with a lot of help from her friends. I hope the world can use this for better #machinelearning on enzymes.
A 4-site mutagenesis library of the enzyme TrpB
- captures epistatic effects
- best variants contain substitution that's rare in natural sequences
- new, large-scale testing ground for model-guided enzyme engineering
@kadinaj @patrickalmhjell @njp_chem @jsunn_y @francesarnold
@Waspwood11 @BokkaL95 I would be interested in the wagering analysis - and I’m sure the #TRPB will be looking at that. I’m no rider but not accelerating is one thing, decelerating is quite another.
Go @aralezBio David Romney, @TinaBoville and the rest of the team #TrpB. This amazing #aminoacid machine (made of and make amino acids!) can make lots of odd parts, at scale.
Our 7th speaker was @TinaBoville from Aralez Bio who gave us a behind the scenes look on “Engineering enzymes for green manufacturing of non-canonical AA’s.” Christina shared how they’re scaling these reactions and what the future might hold. 10/
https://t.co/YRyrmFBqAD
Superstar @Ella_Watkins_ review is now online! Read up on everyone's favorite enzyme, and then you'll see why we're excited to put #TrpB to work @AralezBio.
My latest paper in @ChemBioChem is now out. I can genuinely say that TrpB is such a fun enzyme to work with that I truly enjoyed writing this review to share my passion with the world! What can’t this enzyme do? @francesarnold https://t.co/QC26YNPpbE
Many kudos to @TinaBoville @AralezBio on being named one of MIT @techreview's 35 Under 35! #biocatalysis #enzymes #directedevolution. Tina makes some stunning tryptophan analogs with #TrpB.
I've been named one of this year's 35 Innovators Under 35 for my work at @AralezBio on #biocatalysis and #greenchemistry. At Aralez Bio we engineer enzymes to create a new, more efficient path to manufacturing useful chemicals.
https://t.co/UO6DxouI4R
How does this horse pay 18-1? Racing oversight person in charge please explain publicly on Twitter. Thanks in advance. #TRPB transparency
Az-ooh-la-la! We are proud to present a facile, one-pot, enzyme catalyzed synthesis of the brilliant blue noncanonical amino acid AzAla. @francesarnold @AralezBio #directedevolution #trpb #arnoldlab #molecularbiology #biocatalysis
A good day for TrpB! @Ella_Watkins_ and I show that azulene is a promiscuous substrate for tryptophan synthase and then use #directedevolution to improve this activity, synthesizing a gram of a deep-blue fluorescent ncAA in one step https://t.co/vcTiPo9u0K
#TRPB Los Miuras no se presentará hoy en Santa Rosa. El local, que era una fija para ganar ese partido vs el último del grupo, avanza a Reubicación A-B como 2do. Esta situación deja el match @CUBBrugby vs #Los50 (15.15 en el Gatica) con estatus de "sólo para cumplir".
#TRPB en 20 m @clubargentinobb vence a @LosCardosRC por 21 a 0 con tres trys de Souville y convertidos por Selvarolo . #Vamosazul
#TRPB al final del primer tiempo @clubargentinobb aumenta la diferencia frente a @ClubLos50 a 29 a 0 con los trys de Souville y Biancucci que fueron convertidos por Juan Maccagno #VamosAzul
#TRPB en 20 m @clubargentinobb supera a @ClubLos50 por 15 a 0 con un try penal de Scrum y otro de Guillermo Vila #VamosAzul
#TRPB 55 m try de Agustín Marra convertido por Juan Macagno para que @clubargentinobb pase al frente por 17 a 10 #vamosazul
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