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What happens to a pill 💊 after it reaches the liver and why it is so important? The liver breaks drugs down so the body can get rid of them. Swallowed → Absorbed → Broken down → Cleared One way we measure this is Clint MLM (intrinsic clearance in mice liver microsomes) -- how quickly a drug is broken down by mouse liver enzymes in a lab test 🧪. The faster 🏃‍♂️clearance, the less drug is left in the body, the less the effect of the drug. Can frontier models predict this from molecular structure alone with no tools/orchestration❓ Opus 5 came out on top 🏆 for Clint MLM prediction, with a Spearman correlation of 0.425. Check our #DDDBench site to see how better is Opus 5 compared to other frontier models.