Top Tweets for #VariantHunters
#SARSCoV2 Updates
Looks like XEC is driving a slight uptick in #COVID19 #Hospitalizations in #NewYork | @HealthNYGov
LP.8.1 is another lineage that #VariantHunters are closely monitoring (~60% of LP.8.1 sequences submitted via airport surveillance in the last 30 days)
Status of #COVID19 in #NewYork (#Bellwether State)
XEC is the top circulating #SARSCoV2 lineage in NY
#COVID19 hospitalizations ⬆️ (trending up)
#WasteWater #SARSCoV2 - overall minimal level - but some sites have high viral load| @HealthNYGov
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#VariantHunters are closely monitoring XEC.1 with signature mutations Spike K182R & ORF1a:L4182F
KP.3 group of lineages (as of 6/21/2024)
#VariantHunters are closely following KP.3 sub-lineages including KP.3.1.1(Signature Spike S31del)
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#SARSCoV2 lineages
How #VariantHunters nickname convergent combo mutations?
[OG Amino acid single letter code] [Mutation single letter code] (optional spacer(s) -vowel) followed by the codes for the next mutation.
For example: Spike F456L & R346T combo: #FLiRT
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![RajlabN's tweet photo. #SARSCoV2 lineages
How #VariantHunters nickname convergent combo mutations?
[OG Amino acid single letter code] [Mutation single letter code] (optional spacer(s) -vowel) followed by the codes for the next mutation.
For example: Spike F456L & R346T combo: #FLiRT
1/n https://t.co/wEOjpiST1R](https://pbs.twimg.com/media/GPewCFeWcAA2GIU.jpg)
KP.3 group of lineages (as of 6/7/2024)
#VariantHunters are closely following KP.3 sub-lineages including KP.3.1.1(Signature Spike S31del)
https://t.co/Y0ezHOjE94
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#SARSCoV2 Updates
KP.3 group of lineages (as of 6/4/2024)
Thanks to all the testing and sequencing labs, #VariantHunters that are tirelessly spotting and proposing lineages, @PangoNetwork for designating lineages and all others who made this possible with their tools, techniques and expertise
Several #VariantHunters: @EmilyAnne_Smith, @PeacockFlu, @shay_fleishon and others shared early insights.. especially highlighted the sequence from the human specimen...
https://t.co/EFpEMq5DbM
This tree shows divergence in the HA gene. Note that the HA gene segments for all of the samples from TX dairy cattle are nearly identical. The recent human case from TX falls within a clade that contains those dairy cattle samples, as well as samples from wild birds in TX 2/7
JN.1.23 (w/ S:Y453F) is currently one of the lineages closely watched by #VariantHunters
Early days but its predicted ACE binding >> JN.1 without comprising its high immune escape potential
Currently this has the potential to outcompete other circulating JN.1* & recombinants
@CDCgov @HealthNYGov Predicted Immune Escape Vs ACE2 Binding (relative to BA.2)
Have a look at JN.1.23 (high IE & high ACE2 binding)
Spotted by top #VariantHunter @LongDesertTrain (https://t.co/J1wCAQm6KN)
Predicted IE vs ACE2 binding score chart - #USA #30DayTrends: https://t.co/LEtyEEPnj4
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@mvankerkhove @WHO .@JPWeiland @michael_hoerger @LongDesertTrain @RajlabN @UseBy2022 @ejustin46 @HarrySpoelstra @xabitron1 @TRyanGregory
To name a few! 💥💥💥
#VariantHunters who are quite literally saving the world!! 👇🏻
A big thank you to all the #VariantHunters for spotting/submitting lineage proposals
A huge thank you to labs that are collecting specimen, sequencing and rapidly submitting it to public domain databases like @GISAID @NCBI
.@JPWeiland has been providing accurate models throughout the pandemic. Surprised to hear that his @gisaid access has not been approved yet.
Joins the list of #varianthunters @LongDesertTrain @siamosolocani and others who waited several months before getting their access!
I still don't have access to @GISAID (continuing to apply!!) which always lags the data I can access by 3 or 4 days.
@Asinickle1 @RajlabN @wolfeagle1989 and @Mike_Honey_ have been fantastic in providing "live" data to help run some of these analysis on JN.1. A huge thank you!
A well deserved feature highlighting tireless #VariantHunters
Honored to be featured alongside @JosetteSchoenma, @Asinickle1, @nzm8qs, & @siamosolocani in this article from @guardian that contains quotes from @PeacockFlu, @shay_fleishon, and @TRyanGregory. Many thanks to author @LindaGeddes for the excellent story! https://t.co/qjb8S2AUmw
@LongDesertTrain @JosetteSchoenma @Asinickle1 @nzm8qs @siamosolocani @guardian @PeacockFlu @shay_fleishon @TRyanGregory @LindaGeddes Thank you to Ryan and all the #VariantHunters!! 🫡🫡🫡
This story will be a thriller movie one day!! 🎬🎬🎬
#Varianthunters are tracking NSP12 P323L/G671S (#SARSCoV2 ORF1b) that facilitates enhanced virus replication in #ferret upper airways and higher transmissibility
I recon the presence of intact #NS8 in BA.2.86 could make a difference
H/T Yat Sing ng, @siamosolocani @JPWeiland
BA.2.86 Pirola is quickly evolving tricks.
@siamosolocani alerted us to a Orf1b:G662S mutation in South Africa. All the circulating strains picked this up a while back and @LongDesertTrain sees it pop up in many cryptics.
Thought to increase replication temperature stability.
@UseBy2022 Absolutely incredible article and a handsome photo of @siamosolocani❤️🫡.
Folks, you’ll want to hit the “translate” button on this to read about how the #VariantHunters assembled!
Very emotional because they have saved many, many lives.🙏🏻
One day this will be a thriller movie!
We are so grateful to #varianthunters for their work. Their alternative nomenclature is useful and not to blame per se, but just because it ignores the rules set years ago in order to avoid stigma and emotional reactions to infectious diseases. Maybe you just need to talk, dudes!
#varianthunters I wonder if we shouldn't have more cases of BA.2.286 at this time. No more detection after USA's? Could it be a false alarm? Is it just a lack of sequencing all over the world? @siamosolocani @TRyanGregory @SolidEvidence @CorneliusRoemer
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