#WhatTheHel - Twitter Hashtag

over 1 year ago

#WhatTheHel Maniac leaves ‘bomb’ with chilling note in front of West Village NYPD precinct: ‘Chlorine gas is a bitch’ https://t.co/hEyivOdbsI

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Saran @Saran_CN

over 1 year ago

Latest publication from our lab. Take a look to find out what the protein HelD does when it encounters Rifampicin! #AntimicrobialResistance #mycobacteria #Rifampicin #WhattheHel

IOCB Prague

@IOCBPrague

over 1 year ago

One of the main challenges of contemporary medicine is posed by the resistance of pathogens to antibiotics. An important step in countering it has now been made by @tm_kouba and colleagues from @IOCBPrague, in collaboration with researchers led by Libor Krásný from the Institute of Microbiology and Jan Dohnálek of @IBT_CAS @CzechAcademy. Leveraging advanced #cryoEM and biochemical methods, they have managed to describe how mycobacteria defend themselves against the antibiotic #rifampicin. One key component that allows a bacterium to dodge the action of the antibiotic rifampicin is a protein called HelD. It effectively protects bacterial #RNApolymerase, which is the enzyme taking care of the transcription of genetic information from DNA to RNA, a process that is crucial for the survival of all bacteria. The HelD protein acts as a cellular bodyguard. Whenever there's a snag during the transcription of DNA, HelD comes to the rescue, and this is also what happens after the administration of rifampicin, the role of which is to inhibit RNA polymerase. Without HelD, the whole process would grind to a halt and the bacterium would perish. HelD does not yield even to such a powerful antibiotic as rifampicin, which is used, for example, to treat tuberculosis or severe pneumonia. Until recently, researchers had assumed that HelD played a crucial role in antibiotic resistance. However, they have found that it is even more important for bacteria than it seemed. The HelD protein not only sets RNA polymerase free from the effects of the antibiotic but also ensures the ‘recycling’ of this enzyme, which is crucial for the functioning of every organism. It achieves this by actually moving RNA polymerase to the transcription initiation site on DNA, allowing it to resume transcription. The bacterium can thus start multiplying again. 📜 Read the original @NatureComms study: https://t.co/ZRhNg3vSIB 📰 Read more about the study: https://t.co/rJf50uGpZI

IOCBPrague's tweet photo. One of the main challenges of contemporary medicine is posed by the resistance of pathogens to antibiotics. An important step in countering it has now been made by @tm_kouba and colleagues from @IOCBPrague, in collaboration with researchers led by Libor Krásný from the Institute of Microbiology and Jan Dohnálek of @IBT_CAS @CzechAcademy.

Leveraging advanced #cryoEM and biochemical methods, they have managed to describe how mycobacteria defend themselves against the antibiotic #rifampicin.

One key component that allows a bacterium to dodge the action of the antibiotic rifampicin is a protein called HelD. It effectively protects bacterial #RNApolymerase, which is the enzyme taking care of the transcription of genetic information from DNA to RNA, a process that is crucial for the survival of all bacteria.

The HelD protein acts as a cellular bodyguard. Whenever there's a snag during the transcription of DNA, HelD comes to the rescue, and this is also what happens after the administration of rifampicin, the role of which is to inhibit RNA polymerase. Without HelD, the whole process would grind to a halt and the bacterium would perish. HelD does not yield even to such a powerful antibiotic as rifampicin, which is used, for example, to treat tuberculosis or severe pneumonia.

Until recently, researchers had assumed that HelD played a crucial role in antibiotic resistance. However, they have found that it is even more important for bacteria than it seemed. The HelD protein not only sets RNA polymerase free from the effects of the antibiotic but also ensures the ‘recycling’ of this enzyme, which is crucial for the functioning of every organism. It achieves this by actually moving RNA polymerase to the transcription initiation site on DNA, allowing it to resume transcription. The bacterium can thus start multiplying again.

📜 Read the original @NatureComms study: https://t.co/ZRhNg3vSIB

📰 Read more about the study: https://t.co/rJf50uGpZI

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hel | vtuber ❤️ @waifuhel

over 2 years ago

everyday for the next 100 days i will post an image from my collection of Ghastly Things 1/100 #whatthehel

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hel | vtuber ❤️ @waifuhel

over 2 years ago

JUMPSCARE WARNING ShlumpedYdd always clips my favorite moments ;3; <333 [#whatthehel #VTuberUprising #VTuberEN]

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VeX_PenTheElf (PJ)

@Eunha_Cactus

over 2 years ago

@waifuhel @GordonRamsay Actually wait that should be like a hashtag for you #WhatTheHel for moments like this.

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Penny | 🖤👑 @penstormborn

over 3 years ago

@gratefullygwen @ThatTrable She'll be like yeah, I made a deal with the Prince of Hel to help me with stuff and bring me back to Dusk Court, cuz Lunathion was too dangerous 🙊 Bryce better light her up 🙈 After what she went through, it's finna be a Starborn smackdown 🤣😂 #WhatTheHel

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Tino @TinoFalke

over 4 years ago

Nachdem die Post zwei Wochen (!) unterwegs war, habe ich jetzt auch endlich die gedruckte Version der Kurzgeschichte #WhatTheHel von @schreibmaid. ☺️ Mit Charakter-Artwork! Vielen Dank, ich bin gespannt!

TinoFalke's tweet photo. Nachdem die Post zwei Wochen (!) unterwegs war, habe ich jetzt auch endlich die gedruckte Version der Kurzgeschichte #WhatTheHel von @schreibmaid. ☺️ Mit Charakter-Artwork! Vielen Dank, ich bin gespannt! https://t.co/w4RDFMu4R6

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Laura S. @tastentaenzerin

almost 5 years ago

Treat yourself und bestellt euch #WhatTheHel vor! Ich durfte es schon lesen und 10/10, würde mich auch blitzdingsen, damit ichs nochmal zum ersten Mal lesen kann! 💙

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Kevin Lambert

@kevinlambert

over 7 years ago

@HelenAngel @javierabegazo How could you leave out Mario Odyssey and Breath of the Wild? #WhatTheHel

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What the HEL from Finland @what_the_hel_

almost 8 years ago

@NesteGlobal created a compelling space, where people could experience a more sustainable way of living: the Nolla cabin by Neste. @IDSvancouver #nollacabin #neste #WhattheHELfromFinland #WtH #WhattheHEL #finnishdesign #futuretrends

what_the_hel_'s tweet photo. @NesteGlobal created a compelling space, where people could experience a more sustainable way of living: the Nolla cabin by Neste. @IDSvancouver #nollacabin #neste #WhattheHELfromFinland #WtH #WhattheHEL #finnishdesign #futuretrends https://t.co/XrUCNs6uUg

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What the HEL from Finland @what_the_hel_

almost 8 years ago

Lapuan Kankurit. The skillful jacquard weaving skills are the result of generations of learning. @LapuanKankurit @IDSvancouver #lapuankankurit #sustainabledesign #madeinfinland #WhattheHELfromFinland #WtH #WhattheHEL #finnishdesign #futuretrends

what_the_hel_'s tweet photo. Lapuan Kankurit. The skillful jacquard weaving skills are the result of generations of learning. @LapuanKankurit @IDSvancouver #lapuankankurit #sustainabledesign #madeinfinland #WhattheHELfromFinland #WtH #WhattheHEL #finnishdesign #futuretrends https://t.co/CQYkAukpkI

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Koruja Matka（ｺﾙﾔﾏﾄｶ）※2018年をもって閉店 @korujamatka

almost 8 years ago

【インテリアデザインショー（カナダ）】#フィンランドの最新&注目デザイナー・ブランド多数紹介！「What the HEL from Finland」にヘイニ・リータフフタも参加！9/20～23まで開催されます。https://t.co/c3RBDDxz8o #finland #design #HeiniRiitahuhta #whatthehel #vancouver #interiordesignshow

korujamatka's tweet photo. 【インテリアデザインショー（カナダ）】#フィンランドの最新&注目デザイナー・ブランド多数紹介！「What the HEL from Finland」にヘイニ・リータフフタも参加！9/20～23まで開催されます。https://t.co/c3RBDDxz8o
#finland #design #HeiniRiitahuhta #whatthehel #vancouver #interiordesignshow https://t.co/LI6g5QgrIK

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Ubah Aden @UbahAden72

over 8 years ago

MuslimNaceybka waxuu bilowdey ku lahaa markuu muslimku ku soo batey yurubta iyo #PunishAMuslimDay #whatthehel. Been maa laysku sheegaa, mise taariikh baan la aqoon? @voasomali

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Doomchinchilla @Doomchinchilla

almost 9 years ago

A lot of interesting things about to happen. To kick off our upcoming campaign, we had Niden make us an art piece. #staywoke #tweetfleet #whatthehel https://t.co/X7F90NLTLX